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AXO-MATH SIGNED

Imaging and analyzing dynamics of reward-related long-range axons during decision-making in behaving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AXO-MATH project word cloud

Explore the words cloud of the AXO-MATH project. It provides you a very rough idea of what is the project "AXO-MATH" about.

viral    tegmental    ventral    behaving    modern    behaviors    abuse    nucleus    hypothesize    society    largely    genetic    mice    tools    analytical    plasticity    prevention    characterization    function    images    expertise    functional    investigates    substance    seamless    pfc    shape    unprecedented    substrates    axonal    micrometer    area    significantly    synaptic    stage    handle    regions    microscopy    expert    math    lack    treatment    action    human    model    image    sensory    receiving    vivo    unknown    interdisciplinary    critical    anatomical    valuation    switch    multidisciplinary    data    projections    participate    learning    diseases    combination    amygdala    mathematical    host    mechanisms    preference    positively    extraction    modulated    input    basolateral    original    autism    network    axons    relationship    automatic    neuronal    schizophrenia    precise    accuracy    deciphering    final    thanks    encode    disorders    neuroscience    dynamics    animal    context    dynamically    dorsal    neuropsychiatric    hub    maladaptive    axo    decision    obsessive    volumes    initial    neuroeconomics    brain   

Project "AXO-MATH" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

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 Project objective

Decision-making is a crucial brain function which neuronal substrates are largely unknown. Deciphering those mechanisms is critical for the prevention and the treatment of brain diseases as decision-making is maladaptive in many neuropsychiatric disorders (obsessive behaviors, schizophrenia, autism, substance abuse); it would also significantly advance neuroeconomics and therefore positively impact society. AXO-MATH (MATHematical analysis of AXOnal projections) investigates the neuronal mechanisms involved in decision-making in behaving mice using interdisciplinary approaches and state-of-the-art methods. We hypothesize that a final step before the action is taken is implemented in the dorsal PFC as it is an anatomical hub receiving projections from both sensory areas and regions believed to participate in choice valuation, such as the ventral tegmental area and the basolateral nucleus of the amygdala. Using an original combination of advanced microscopy and genetic and viral tools, we will image the activity of those long-range axons in two conditions: while the expert animal is taking a choice, and during the stage of preference learning. Precise measures will allow us to test a model in which projections from the amygdala to the PFC encode choice values and can be dynamically modulated as a function of the context by the ventral tegmental area to switch preference. The characterization accuracy will be unprecedented thanks to the design of new analytical tools - the initial expertise of the applicant. We propose novel mathematical methods tailored to the automatic extraction of complex-shape and micrometer-scale features of synaptic activity in in vivo microscopy images; they lack human input and can handle large volumes of data. By a seamless combination of the host and applicant multidisciplinary expertise we will address the relationship between synaptic network dynamics and functional brain plasticity which is a major challenge in modern neuroscience.

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