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AXO-MATH SIGNED

Imaging and analyzing dynamics of reward-related long-range axons during decision-making in behaving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AXO-MATH project word cloud

Explore the words cloud of the AXO-MATH project. It provides you a very rough idea of what is the project "AXO-MATH" about.

unprecedented    treatment    action    abuse    participate    extraction    functional    animal    neuropsychiatric    behaving    neuroscience    expertise    vivo    amygdala    area    lack    positively    valuation    axo    human    handle    hypothesize    math    anatomical    substance    images    function    original    dynamically    deciphering    microscopy    mathematical    axonal    maladaptive    volumes    axons    pfc    modulated    sensory    learning    characterization    mice    preference    interdisciplinary    micrometer    image    receiving    synaptic    input    plasticity    projections    regions    viral    automatic    significantly    dynamics    ventral    critical    decision    brain    final    model    hub    investigates    society    disorders    substrates    shape    neuroeconomics    nucleus    combination    switch    unknown    basolateral    schizophrenia    prevention    analytical    tools    encode    accuracy    data    largely    diseases    host    stage    expert    mechanisms    relationship    network    seamless    initial    autism    genetic    precise    modern    dorsal    neuronal    thanks    behaviors    tegmental    multidisciplinary    context    obsessive   

Project "AXO-MATH" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

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 Project objective

Decision-making is a crucial brain function which neuronal substrates are largely unknown. Deciphering those mechanisms is critical for the prevention and the treatment of brain diseases as decision-making is maladaptive in many neuropsychiatric disorders (obsessive behaviors, schizophrenia, autism, substance abuse); it would also significantly advance neuroeconomics and therefore positively impact society. AXO-MATH (MATHematical analysis of AXOnal projections) investigates the neuronal mechanisms involved in decision-making in behaving mice using interdisciplinary approaches and state-of-the-art methods. We hypothesize that a final step before the action is taken is implemented in the dorsal PFC as it is an anatomical hub receiving projections from both sensory areas and regions believed to participate in choice valuation, such as the ventral tegmental area and the basolateral nucleus of the amygdala. Using an original combination of advanced microscopy and genetic and viral tools, we will image the activity of those long-range axons in two conditions: while the expert animal is taking a choice, and during the stage of preference learning. Precise measures will allow us to test a model in which projections from the amygdala to the PFC encode choice values and can be dynamically modulated as a function of the context by the ventral tegmental area to switch preference. The characterization accuracy will be unprecedented thanks to the design of new analytical tools - the initial expertise of the applicant. We propose novel mathematical methods tailored to the automatic extraction of complex-shape and micrometer-scale features of synaptic activity in in vivo microscopy images; they lack human input and can handle large volumes of data. By a seamless combination of the host and applicant multidisciplinary expertise we will address the relationship between synaptic network dynamics and functional brain plasticity which is a major challenge in modern neuroscience.

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The information about "AXO-MATH" are provided by the European Opendata Portal: CORDIS opendata.

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