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EATing more TERMINATED

Enhancing Engulfment of Apoptotic cells: basic biology to Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EATing more project word cloud

Explore the words cloud of the EATing more project. It provides you a very rough idea of what is the project "EATing more" about.

phagocytes    damaged    complexities    bodies    billions    expertise    uniquely    cellular    autoimmune    deficient    hypothesise    explore    critical    throughput    apoptosis    shown    molecular    diseases    perform    administration    avenues    human    lab    engulf    professional    gain    deficiencies    employ    benefitting    cells    benefit    minimising    inflammation    exploits    organ    clearance    mice    therapy    excess    host    phagocytosis    homeostasis    beginning    myself    turn    deciphered    cleared    contexts    anticipate    disease    exhibit    models    pathology    engulfment    proteomics    function    components    boosted    molecules    enhancers    dying    keep    mechanistic    library    unbiased    day    drug    fluorescence    enhanced    inflammatory    assay    exaggerated    complementary    screen    candidates    efficiency    pharmacologically    healthy    cell    nucleomics    predispose    our    quantitatively    machinery    compounds    candidate    molecule    apoptotic    small   

Project "EATing more" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses. We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts. Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic complexities of apoptotic cell clearance are just beginning to be deciphered, we anticipate that this study will also provide insight into molecular pathways of apoptotic cell uptake and processing.

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The information about "EATING MORE" are provided by the European Opendata Portal: CORDIS opendata.

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