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EATing more TERMINATED

Enhancing Engulfment of Apoptotic cells: basic biology to Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EATing more project word cloud

Explore the words cloud of the EATing more project. It provides you a very rough idea of what is the project "EATing more" about.

efficiency    bodies    billions    employ    gain    beginning    molecular    complexities    throughput    unbiased    deciphered    engulf    hypothesise    boosted    explore    function    cellular    engulfment    predispose    apoptotic    disease    professional    small    phagocytosis    pathology    cell    minimising    avenues    homeostasis    proteomics    contexts    perform    benefit    candidate    pharmacologically    lab    nucleomics    keep    enhancers    benefitting    assay    expertise    screen    components    exaggerated    mice    fluorescence    drug    apoptosis    our    shown    diseases    excess    cells    dying    exploits    molecule    enhanced    turn    compounds    uniquely    inflammation    library    myself    inflammatory    human    mechanistic    machinery    models    quantitatively    therapy    deficient    damaged    critical    exhibit    organ    phagocytes    administration    day    autoimmune    candidates    clearance    cleared    host    molecules    complementary    anticipate    deficiencies    healthy   

Project "EATing more" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses. We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts. Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic complexities of apoptotic cell clearance are just beginning to be deciphered, we anticipate that this study will also provide insight into molecular pathways of apoptotic cell uptake and processing.

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The information about "EATING MORE" are provided by the European Opendata Portal: CORDIS opendata.

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