Opendata, web and dolomites


Enhancing Engulfment of Apoptotic cells: basic biology to Therapy

Total Cost €


EC-Contrib. €






 EATing more project word cloud

Explore the words cloud of the EATing more project. It provides you a very rough idea of what is the project "EATing more" about.

benefitting    therapy    apoptosis    critical    engulfment    shown    autoimmune    healthy    bodies    pharmacologically    dying    administration    molecules    uniquely    billions    screen    function    damaged    unbiased    deciphered    apoptotic    human    complexities    gain    disease    diseases    phagocytes    molecular    models    beginning    host    proteomics    enhancers    nucleomics    exaggerated    enhanced    homeostasis    components    benefit    explore    quantitatively    engulf    turn    hypothesise    drug    efficiency    fluorescence    library    candidate    pathology    predispose    professional    organ    employ    assay    lab    deficiencies    myself    inflammatory    clearance    perform    deficient    contexts    complementary    molecule    machinery    cells    boosted    compounds    anticipate    phagocytosis    inflammation    day    small    cell    keep    cleared    expertise    avenues    mechanistic    cellular    exhibit    minimising    mice    excess    exploits    our    candidates    throughput   

Project "EATing more" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 160˙800.00


 Project objective

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses. We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts. Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic complexities of apoptotic cell clearance are just beginning to be deciphered, we anticipate that this study will also provide insight into molecular pathways of apoptotic cell uptake and processing.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EATING MORE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EATING MORE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ELOTEQ (2019)

Interfacing Levitated Optomechanics with Superconducting Qubits

Read More  


Metal-catalyzed remote functionalization of aliphatic amines and amides triggered by photocatalytic sp3 C-H activation

Read More  

WavyRibbons (2019)

Wavy N-doped Graphene Nanoribbons for Single Molecule Electronics

Read More