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PREVENT RA SIGNED

Towards prevention of autoimmune diseases: the case of rheumatoid arthritis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PREVENT RA" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙161˙250.00
2    REGION STOCKHOLM SE (STOCKHOLM) participant 838˙750.00

Map

 Project objective

A common feature of autoantibody-positive autoimmune disease is that the disease-associated autoimmunity often appears many years prior to clinical onset and can hence be used to identify risk groups for future disease development. Autoantibody-positive (seropositive) rheumatoid arthritis (RA) provides a unique setting due to recent insights in the longitudinal development of the disease, suggesting that autoantibodies develop in genetic susceptible individuals as a consequence of specific environmental challenges (such as smoking) to only later on target the joints. The main objectives of the current program are: (1). To dissect the longitudinal development of seropositive RA and gain a detailed understanding of the processes responsible for autoantibody generation outside the joints, and specifically at the mucosal sites. (2). To develop new ways to identify seropositive disease-susceptible individuals and map targetable life style factors and immune events responsible for this susceptibility. (3). To elucidate the mechanisms by which systemic autoimmunity targets the joints to first induce bone loss and pain and only in a second phase chronic joint inflammation. If successful our project will not only allow efficient identification of RA-susceptible individuals, but also deliver new tools for risk estimation in each of these individuals and novel ways of intervention in order to delay, or in the best case prevent disease development. By shifting the time (to phases before joint damage and disability occurs) and the ways (to drugs targeting early previously unknown pathogenic mechanisms) of interventions, expected results from the current project are beyond the current state of the art in RA.

 Publications

year authors and title journal last update
List of publications.
2018 Kaja Eriksson, Lena Nise, Lars Alfredsson, Anca Irinel Catrina, Johan Askling, Karin Lundberg, Lars Klareskog, Tülay Yucel-Lindberg
Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis
published pages: annrheumdis-2017, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2017-212091
Annals of the Rheumatic Diseases 2020-03-18
2018 Sunithi Gunasekera, Cátia Fernandes-Cerqueira, Stefan Wennmalm, Heidi Wähämaa, Yngve Sommarin, Anca I. Catrina, Per-Johan Jakobsson, Ulf Göransson
Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
published pages: 1525-1535, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00118
ACS Chemical Biology 13/6 2020-03-18
2019 Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus Sköld, Reza Karimi, Sven Nyrén, Anna Svärd, Anca I Catrina, Alf Kastbom
Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis
published pages: , ISSN: 1462-0324, DOI: 10.1093/rheumatology/kez377
Rheumatology 2020-03-18
2018 Marianne Engström, Kaja Eriksson, Linkiat Lee, Monika Hermansson, Anders Johansson, Anthony P. Nicholas, Natalija Gerasimcik, Karin Lundberg, Lars Klareskog, Anca Irinel Catrina, Tülay Yucel-Lindberg
Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis
published pages: , ISSN: 1479-5876, DOI: 10.1186/s12967-018-1588-2
Journal of Translational Medicine 16/1 2020-03-18
2019 Lars Klareskog, Anca Irinel Catrina, Camilla Svensson, Vivianne Malmstrom
How to communicate in science
published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-216016
Annals of the Rheumatic Diseases 2020-03-18
2019 Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, Björn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, Tülay Yucel-Lindberg
Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
published pages: 630, ISSN: 2077-0383, DOI: 10.3390/jcm8050630
Journal of Clinical Medicine 8/5 2020-03-18
2018 Marian H van Beers-Tas, Marieke M ter Wee, Lilian H van Tuyl, Bertha Maat, Wijnanda Hoogland, Aase H Hensvold, Anca I Catrina, Erika Mosor, Tanja A Stamm, Axel Finckh, Delphine S Courvoisier, Andrew Filer, Ilfita Sahbudin, Rebecca J Stack, Karim Raza, Dirkjan van Schaardenburg
Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project
published pages: e000641, ISSN: 2056-5933, DOI: 10.1136/rmdopen-2017-000641
RMD Open 4/1 2020-03-18
2019 Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina
Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts
published pages: 1621-1631, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214967
Annals of the Rheumatic Diseases 78/12 2020-03-18
2019 Akilan Krishnamurthy, A. Jimmy Ytterberg, Meng Sun, Koji Sakuraba, Johanna Steen, Vijay Joshua, Nataliya K. Tarasova, Vivianne Malmström, Heidi Wähämaa, Bence Réthi, Anca I. Catrina
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts
published pages: 3143-3150, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1800534
The Journal of Immunology 202/11 2020-03-18
2018 Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina, Espen Andre Haavardsholm
The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy
published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1635-7
Arthritis Research & Therapy 20/1 2020-03-18
2018 Karine Chemin, Daniel Ramsköld, Lina-Marcela Diaz-Gallo, Jessica Herrath, Miranda Houtman, Karolina Tandre, Lars Rönnblom, Anca Catrina, Vivianne Malmström
EOMES-positive CD4 + T cells are increased in PTPN22 (1858T) risk allele carriers
published pages: 655-669, ISSN: 0014-2980, DOI: 10.1002/eji.201747296
European Journal of Immunology 48/4 2020-03-18
2019 Johanna Steen, Björn Forsström, Peter Sahlström, Victoria Odowd, Lena Israelsson, Akilan Krishnamurthy, Sara Badreh, Linda Mathsson Alm, Joanne Compson, Daniel Ramsköld, Welcome Ndlovu, Stephen Rapecki, Monika Hansson, Philip J. Titcombe, Holger Bang, Daniel L. Mueller, Anca I. Catrina, Caroline Grönwall, Karl Skriner, Peter Nilsson, Daniel Lightwood, Lars Klareskog, Vivianne Malmström
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis
published pages: 196-209, ISSN: 2326-5191, DOI: 10.1002/art.40699
Arthritis & Rheumatology 71/2 2020-03-18
2018 Miranda Houtman, Klementy Shchetynsky, Karine Chemin, Aase Haj Hensvold, Daniel Ramsköld, Karolina Tandre, Maija-Leena Eloranta, Lars Rönnblom, Steffen Uebe, Anca Irinel Catrina, Vivianne Malmström, Leonid Padyukov
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
published pages: 28-38, ISSN: 0896-8411, DOI: 10.1016/j.jaut.2018.01.003
Journal of Autoimmunity 90 2020-03-18
2018 Aase Haj Hensvold, Anca I Catrina
Challenging judgement of a low-positive ACPA test in the context of individuals at risk of RA
published pages: annrheumdis-2016, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2016-211062
Annals of the Rheumatic Diseases 2020-03-18

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