Opendata, web and dolomites

NanoMop SIGNED

Smart Cholesterol-Mopping Polymer Nanoparticles in Niemann-Pick Disease Type C

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NanoMop project word cloud

Explore the words cloud of the NanoMop project. It provides you a very rough idea of what is the project "NanoMop" about.

pick    bioavailability    limitations    poor    therapeutic    subsequent    chemical    brain    considerable    edge    urgently    occurring    mobility    personally    suffers    networking    chemistry    broaden    horizon2020    international    nanoparticles    cognitive    stakeholders    polymer    npc    accumulation    recognised    detected    pursue    modification    academic    capacity    treatment    carry    players    bcd    people    competences    successful    industrial    techniques    diversify    professionally    cutting    naturally    charity    profile    pharmacokinetics    excellent    designed    area    sugars    career    line    nanomops    incidence    internationally    interdisciplinary    independent    decline    sequester    create    childhood    successfully    cyclodextrins    niemann    biological    cds    training    gained    threatening    health    decade    alzheimer    family    researcher    life    position    genetic    inter    overcome    therapies    disorder    complications    question    puts    rare    caused    answered    class    reaching    disease    smart    fellowship    progress    bcds    completion    me    intervention    sectoral    significantly    macromolecular    cholesterol    skillset   

Project "NanoMop" data sheet

The following table provides information about the project.

Coordinator
ISTANBUL TEKNIK UNIVERSITESI 

Organization address
address: AYAZAGA KAMPUSU
city: MASLAK ISTANBUL
postcode: 34469
website: www.itu.edu.tr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Turkey [TR]
 Total cost 145˙845 €
 EC max contribution 145˙845 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTANBUL TEKNIK UNIVERSITESI TR (MASLAK ISTANBUL) coordinator 145˙845.00

Map

 Project objective

Niemann-Pick Disease Type C (NPC), also known as “childhood Alzheimer’s”, is a rare genetic disorder caused by the accumulation of cholesterol particularly in the brain with subsequent cognitive and mobility decline. In the EU NPC has an incidence of 1 per 100,000 people. Most cases are detected during childhood and progress to cause life-threatening complications by the second or third decade of life. Cyclodextrins (CDs), a family of naturally occurring sugars, have recently gained considerable attention as a potential therapeutic intervention in the treatment of the disease because of their capacity to sequester cholesterol. Although promising, the current treatment of NPC based on a chemical modification of bCD suffers from poor pharmacokinetics and bioavailability in the brain. In this project I propose a new interdisciplinary approach in which bCDs will be embedded into a novel class of smart polymer nanoparticles (NanoMops) that could overcome these limitations. The project addresses an important question that needs to be answered urgently and its successful completion will contribute to the treatment of the neglected disease in line with the Horizon2020 health goal of providing better and more effective therapies. My specific skillset in chemical modification of CDs puts me in a unique position to successfully carry out this project. This interdisciplinary proposal is designed to provide me with advanced training in macromolecular chemistry and in a range of cutting-edge biological techniques. The fellowship will significantly diversify my competences and broaden my profile – professionally and personally - enabling me to pursue a career as an internationally recognised independent researcher. The project will also create new important international and inter-sectoral partnerships with excellent academic and industrial players while reaching out to charity organisations, raising awareness and networking researchers and key stakeholders in the area of NPC.

 Publications

year authors and title journal last update
List of publications.
2019 Antonino Puglisi, Ece Bayir, Suna Timur, Yusuf Yagci
pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents
published pages: 4001-4007, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01083
Biomacromolecules 20/10 2019-10-30
2019 Antonino Puglisi, Yusuf Yagci
Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C
published pages: 1800557, ISSN: 1022-1336, DOI: 10.1002/marc.201800557
Macromolecular Rapid Communications 40/1 2019-09-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOMOP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANOMOP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

StressOME (2019)

Defining and modulating the stress granule proteome as a therapeutic strategy in Amyotrophic Lateral Sclerosis

Read More  

GHSO (2019)

Generation of human steroid-producing organoids: a new approach to treat adrenal insufficiency

Read More  

Oncogenic PI3-kinase (2019)

New biology of oncogenic PI 3-kinase

Read More