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NanoMop SIGNED

Smart Cholesterol-Mopping Polymer Nanoparticles in Niemann-Pick Disease Type C

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NanoMop project word cloud

Explore the words cloud of the NanoMop project. It provides you a very rough idea of what is the project "NanoMop" about.

life    networking    sugars    sectoral    caused    pursue    successful    successfully    cyclodextrins    nanomops    limitations    edge    nanoparticles    bcd    recognised    fellowship    line    carry    macromolecular    interdisciplinary    poor    subsequent    complications    pharmacokinetics    puts    question    childhood    bioavailability    therapies    genetic    decade    me    detected    chemistry    horizon2020    intervention    alzheimer    industrial    brain    incidence    polymer    skillset    completion    cognitive    position    international    threatening    urgently    profile    chemical    health    players    competences    class    significantly    answered    create    career    charity    naturally    internationally    sequester    cholesterol    techniques    modification    biological    family    niemann    decline    pick    progress    inter    reaching    training    designed    overcome    disease    capacity    npc    accumulation    rare    cds    excellent    cutting    area    gained    mobility    people    smart    bcds    researcher    diversify    stakeholders    disorder    treatment    academic    independent    occurring    considerable    suffers    professionally    personally    broaden    therapeutic   

Project "NanoMop" data sheet

The following table provides information about the project.

Coordinator
ISTANBUL TEKNIK UNIVERSITESI 

Organization address
address: AYAZAGA KAMPUSU
city: MASLAK ISTANBUL
postcode: 34469
website: www.itu.edu.tr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Turkey [TR]
 Total cost 145˙845 €
 EC max contribution 145˙845 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTANBUL TEKNIK UNIVERSITESI TR (MASLAK ISTANBUL) coordinator 145˙845.00

Map

 Project objective

Niemann-Pick Disease Type C (NPC), also known as “childhood Alzheimer’s”, is a rare genetic disorder caused by the accumulation of cholesterol particularly in the brain with subsequent cognitive and mobility decline. In the EU NPC has an incidence of 1 per 100,000 people. Most cases are detected during childhood and progress to cause life-threatening complications by the second or third decade of life. Cyclodextrins (CDs), a family of naturally occurring sugars, have recently gained considerable attention as a potential therapeutic intervention in the treatment of the disease because of their capacity to sequester cholesterol. Although promising, the current treatment of NPC based on a chemical modification of bCD suffers from poor pharmacokinetics and bioavailability in the brain. In this project I propose a new interdisciplinary approach in which bCDs will be embedded into a novel class of smart polymer nanoparticles (NanoMops) that could overcome these limitations. The project addresses an important question that needs to be answered urgently and its successful completion will contribute to the treatment of the neglected disease in line with the Horizon2020 health goal of providing better and more effective therapies. My specific skillset in chemical modification of CDs puts me in a unique position to successfully carry out this project. This interdisciplinary proposal is designed to provide me with advanced training in macromolecular chemistry and in a range of cutting-edge biological techniques. The fellowship will significantly diversify my competences and broaden my profile – professionally and personally - enabling me to pursue a career as an internationally recognised independent researcher. The project will also create new important international and inter-sectoral partnerships with excellent academic and industrial players while reaching out to charity organisations, raising awareness and networking researchers and key stakeholders in the area of NPC.

 Publications

year authors and title journal last update
List of publications.
2019 Antonino Puglisi, Ece Bayir, Suna Timur, Yusuf Yagci
pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents
published pages: 4001-4007, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01083
Biomacromolecules 20/10 2019-10-30
2019 Antonino Puglisi, Yusuf Yagci
Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C
published pages: 1800557, ISSN: 1022-1336, DOI: 10.1002/marc.201800557
Macromolecular Rapid Communications 40/1 2019-09-26

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