Opendata, web and dolomites

SPECIFIC fMRI

From surrogate hemodynamics-based fMRI towards direct functional imaging of neural activity via sensing activity-induced cell swellings and neurotransmitter releases in vivo

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SPECIFIC fMRI project word cloud

Explore the words cloud of the SPECIFIC fMRI project. It provides you a very rough idea of what is the project "SPECIFIC fMRI" about.

microstructural    microstructure    dynamics    detect    sufficiently    spin    snr    cellular    true    relationships    harness    oscillating    simulations    circuitry    noninvasive    neural    fidelity    slow    paradigm    enhanced    resonance    exquisite    unprecedented    direct    mr    hemodynamic    functional    indirect    imaging    mrs    detection    nogse    metabolites    sizes    shift    hypothesize    sensing    mri    release    posit    extraordinary    uniform    active    brain    underlying    noninvasively    optogenetics    detects    tag    echo    hemodynamics    probe    casual    nevertheless    seconds    detected    technique       gradient    ultrahigh    recording    signal    gt    couple    pioneered    complementary    cell    stroboscopic    independent    elicited    magnetic    glutamate    firings    gaba    subtle    neurotransmitter    activation    sensitivity    global    circuits    sense    signals    nature    spectral    indirectly    vivo    re    hence    convey    spectroscopy    fmri    relaxation    resolve    mapping    relying    swellings       experiments    conventional    neurovasculature    metabolic    predict    regions    couplings    robustly    probing       function    transformed    sensitive   

Project "SPECIFIC fMRI" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://neuro.fchampalimaud.org/en/research/investigators/research-groups/group/Shemesh/
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 160˙635.00

Map

 Project objective

Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag ‘active’ brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known.

We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-MRI is an exquisite microstructural probe, sensing cell sizes (l) with an unprecedented l^6 sensitivity (compared to l^2 in conventional approaches); RE MRS is a new spectral technique capable of recording metabolic signals with extraordinary fidelity at ultrahigh fields.

This proposal aims to harness these novel concepts for mapping neural activity directly, without relying on hemodynamics.

The specific objectives of this proposal are: (1) Mapping neural activity via sensing cell swellings upon activity: we hypothesize that NOGSE-fMRI can robustly sense subtle changes in cellular microstructure upon neural firings and hence convey neural activity directly. (2) Probing the nature of elicited activity via detection of neurotransmitter release: we posit that RE MRS is sufficiently sensitive to robustly detect changes in Glutamate and GABA signals upon activation. (3) Investigating widespread neural circuits in vivo via stroboscopic optogenetics: we propose to couple NOGSE-fMRI with optogenetics to resolve casual dynamics in global neural circuitry.

Simulations for NOGSE-fMRI predict >4% signal changes upon subtle cell swellings; further, our in vivo RE MRS experiments have detected metabolites with SNR>50 in only 6 seconds. Hence, these two complementary –and importantly, hemodynamics-independent– approaches will represent a true paradigm shift: from indirect detection of neurovasculature couplings towards direct and noninvasive mapping of neural activity in vivo.

 Publications

year authors and title journal last update
List of publications.
2017 Andrada IanuÅŸ, Noam Shemesh, Daniel C. Alexander, Ivana Drobnjak
Double oscillating diffusion encoding and sensitivity to microscopic anisotropy
published pages: 550-564, ISSN: 0740-3194, DOI: 10.1002/mrm.26393
Magnetic Resonance in Medicine 78/2 2019-06-13
2017 Daniel Nunes, Tomás L. Cruz, Sune N. Jespersen, Noam Shemesh
Mapping axonal density and average diameter using non-monotonic time-dependent gradient-echo MRI
published pages: 117-130, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.02.017
Journal of Magnetic Resonance 277 2019-06-13
2017 Andrada IanuÅŸ, Noam Shemesh
Incomplete initial nutation diffusion imaging: An ultrafast, single-scan approach for diffusion mapping
published pages: , ISSN: 0740-3194, DOI: 10.1002/mrm.26894
Magnetic Resonance in Medicine 2019-06-13
2017 Sune Nørhøj Jespersen, Jonas Lynge Olesen, Brian Hansen, Noam Shemesh
Diffusion time dependence of microstructural parameters in fixed spinal cord
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.08.039
NeuroImage 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPECIFIC FMRI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPECIFIC FMRI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

VINCI (2020)

The Value of Information and Choice to Improve Control.

Read More