Explore the words cloud of the SPECIFIC fMRI project. It provides you a very rough idea of what is the project "SPECIFIC fMRI" about.
The following table provides information about the project.
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
|Coordinator Country||Portugal [PT]|
|Total cost||160˙635 €|
|EC max contribution||160˙635 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-04-01 to 2017-03-31|
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|1||FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD||PT (LISBOA)||coordinator||160˙635.00|
Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag ‘active’ brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known.
We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-MRI is an exquisite microstructural probe, sensing cell sizes (l) with an unprecedented l^6 sensitivity (compared to l^2 in conventional approaches); RE MRS is a new spectral technique capable of recording metabolic signals with extraordinary fidelity at ultrahigh fields.
This proposal aims to harness these novel concepts for mapping neural activity directly, without relying on hemodynamics.
The specific objectives of this proposal are: (1) Mapping neural activity via sensing cell swellings upon activity: we hypothesize that NOGSE-fMRI can robustly sense subtle changes in cellular microstructure upon neural firings and hence convey neural activity directly. (2) Probing the nature of elicited activity via detection of neurotransmitter release: we posit that RE MRS is sufficiently sensitive to robustly detect changes in Glutamate and GABA signals upon activation. (3) Investigating widespread neural circuits in vivo via stroboscopic optogenetics: we propose to couple NOGSE-fMRI with optogenetics to resolve casual dynamics in global neural circuitry.
Simulations for NOGSE-fMRI predict >4% signal changes upon subtle cell swellings; further, our in vivo RE MRS experiments have detected metabolites with SNR>50 in only 6 seconds. Hence, these two complementary –and importantly, hemodynamics-independent– approaches will represent a true paradigm shift: from indirect detection of neurovasculature couplings towards direct and noninvasive mapping of neural activity in vivo.
|year||authors and title||journal||last update|
Andrada IanuÅŸ, Noam Shemesh, Daniel C. Alexander, Ivana Drobnjak
Double oscillating diffusion encoding and sensitivity to microscopic anisotropy
published pages: 550-564, ISSN: 0740-3194, DOI: 10.1002/mrm.26393
|Magnetic Resonance in Medicine 78/2||2019-06-13|
Daniel Nunes, TomÃ¡s L. Cruz, Sune N. Jespersen, Noam Shemesh
Mapping axonal density and average diameter using non-monotonic time-dependent gradient-echo MRI
published pages: 117-130, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.02.017
|Journal of Magnetic Resonance 277||2019-06-13|
Andrada IanuÅŸ, Noam Shemesh
Incomplete initial nutation diffusion imaging: An ultrafast, single-scan approach for diffusion mapping
published pages: , ISSN: 0740-3194, DOI: 10.1002/mrm.26894
|Magnetic Resonance in Medicine||2019-06-13|
Sune NÃ¸rhÃ¸j Jespersen, Jonas Lynge Olesen, Brian Hansen, Noam Shemesh
Diffusion time dependence of microstructural parameters in fixed spinal cord
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.08.039
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