Opendata, web and dolomites


GENetics and the Electrocardiogram for predicting Scd rISk

Total Cost €


EC-Contrib. €






Project "GENESIS" data sheet

The following table provides information about the project.


Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-18   to  2021-03-17


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Sudden cardiac death (SCD), a main consequence of malignant ventricular arrhythmias, is a leading cause of cardiovascular mortality in the general population. The early identification of individuals at risk is important. The spatio-temporal dispersion of ventricular repolarization is recognized as one of the major factors modulating the vulnerability to malignant arrhythmias and SCD. The morphology of the T-wave has been proposed to specifically reflect dispersion of ventricular repolarization. As part of my Ph.D, I developed a signal processing method to quantify the single-lead T-wave morphology restitution (TMR) index and I have shown that is strongly associated with SCD risk, but its relationship with intracardiac indices of dispersion of repolarization has never been evaluated. In addition, genome-wide association studies have been successful in identifying genetic variants for ECG indices in the general population, but no previous publications have reported SNPs significantly associated with the T-wave morphology. The main objective of this project is to establish and test a novel effective approach to prevent SCD based on the combination of information derived from cardiac electrophysiological indices and genetic predisposition. The project has three parts: 1) To develop a novel ECG risk marker based on the adaptation of 3D T-wave morphological variations to heart rate changes with strong SCD predictive value. 2) To assess the interaction of non-invasive ECG indices with intra-cardiac electrophysiological indices simultaneously measured during invasive electrophysiological studies. 3) To generate personalized risk scores combining genetics, ECG indices and clinical variables to optimize SCD prediction. This project has the ambition of establishing a new approach to SCD prediction, where genetic screening and advanced cardiac electrophysiological analysis are combined to provide an improved assessment of the predisposition to malignant arrhythmic events.


year authors and title journal last update
List of publications.
2019 Kenneth Fung, Julia Ramírez, Helen R. Warren, Nay Aung, Aaron M. Lee, Evan Tzanis, Steffen E. Petersen, Patricia B. Munroe
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45703-0
Scientific Reports 9/1 2019-10-01

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENESIS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GENESIS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

NeuroSens (2019)

Neuromodulation of Sensory Processing

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More