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NewBorN SIGNED

Unveiling new B-, N- containing structures through photoredox catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NewBorN project word cloud

Explore the words cloud of the NewBorN project. It provides you a very rough idea of what is the project "NewBorN" about.

beta    linear    carefully    avenue    emerged    moieties    oxidative    scientific    ester    involve    forging    rearrangements    boron    create    functionalized    scope    combining    foundations    cyclic    preparation    transformations    followed    mycobacterium    tremendously    bonds    compounds    amino    formed    endeavour    mechanistic    diversely    physical    benefit    synthetic    acids    intramolecular    cyclizations    structures    lay    astrazeneca    metallate    synthesis    host    fundamental    complexes    boronate    amines    antibacterial    vinyl    preliminary    harbouring    radicals    radical    chemical    chemistry    bearing    group    merge    mild    solid    networks    boronic    pot    esters    centred    academic    researcher    reactive    species    synthetically    suite    community    catalysis    emerge    generate    decade    organic    transfer    efficient    meanwhile    migration    rearrangement    versatile    biological    stereoselective    reaction    tuberculosis    photoredox    strategy   

Project "NewBorN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-31   to  2020-07-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 195˙454.00

Map

 Project objective

In the past decade, photoredox catalysis has emerged as a tremendously versatile process to generate reactive radical species in organic synthesis under very mild conditions. Meanwhile, the host group have developed a suite of transformations exploiting the fundamental chemistry of boron, many of which involve 1,2-metallate rearrangement of boronate complexes. In this proposal, we propose to merge the N-centred radicals generated through photoredox catalysis and 1,2-metallate rearrangements of vinyl boronate complexes to create an efficient new strategy for organic synthesis, which will lead to a novel three component reaction where new C–C and C–N bonds are formed in one-pot, providing a new synthetic avenue for the preparation of β-amino boronic esters. Moreover, intramolecular radical cyclizations followed by oxidative 1,2-migration will enable the stereoselective synthesis of diversely functionalized cyclic amines. The scope of these processes will be carefully investigated, and mechanistic studies will be carried out using advanced physical/chemical methods. These novel methodologies not only benefit from the formation of highly functionalized products bearing both synthetically versatile boronic ester and amino moieties, but also lay solid foundations for the development of this new field. Based on the significant antibacterial activity against Mycobacterium tuberculosis of β-amino boronic acids, a preliminary test of the biological activities of compounds obtained throughout the proposed research (both cyclic and linear β-amino-boronic acids) will be carried out in collaboration with AstraZeneca. By combining two major fields of endeavour, new chemistry will emerge with unique structures harbouring novel properties for exploitation. Furthermore this project will enable significant knowledge transfer between host and researcher, while forging new academic networks within the scientific community.

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The information about "NEWBORN" are provided by the European Opendata Portal: CORDIS opendata.

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