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NewBorN SIGNED

Unveiling new B-, N- containing structures through photoredox catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NewBorN project word cloud

Explore the words cloud of the NewBorN project. It provides you a very rough idea of what is the project "NewBorN" about.

transformations    stereoselective    mechanistic    endeavour    intramolecular    mild    vinyl    centred    synthetically    preparation    photoredox    benefit    synthesis    esters    formed    create    emerge    fundamental    scientific    linear    foundations    beta    astrazeneca    chemistry    diversely    boron    acids    avenue    rearrangements    forging    networks    preliminary    mycobacterium    cyclic    cyclizations    pot    physical    lay    migration    radical    boronate    reaction    suite    combining    structures    researcher    biological    merge    strategy    boronic    reactive    group    complexes    host    efficient    metallate    bonds    community    oxidative    bearing    involve    scope    moieties    rearrangement    followed    meanwhile    synthetic    antibacterial    tremendously    emerged    carefully    generate    organic    transfer    versatile    radicals    amino    catalysis    compounds    solid    functionalized    tuberculosis    harbouring    species    amines    decade    academic    ester    chemical   

Project "NewBorN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-31   to  2020-07-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 195˙454.00

Map

 Project objective

In the past decade, photoredox catalysis has emerged as a tremendously versatile process to generate reactive radical species in organic synthesis under very mild conditions. Meanwhile, the host group have developed a suite of transformations exploiting the fundamental chemistry of boron, many of which involve 1,2-metallate rearrangement of boronate complexes. In this proposal, we propose to merge the N-centred radicals generated through photoredox catalysis and 1,2-metallate rearrangements of vinyl boronate complexes to create an efficient new strategy for organic synthesis, which will lead to a novel three component reaction where new C–C and C–N bonds are formed in one-pot, providing a new synthetic avenue for the preparation of β-amino boronic esters. Moreover, intramolecular radical cyclizations followed by oxidative 1,2-migration will enable the stereoselective synthesis of diversely functionalized cyclic amines. The scope of these processes will be carefully investigated, and mechanistic studies will be carried out using advanced physical/chemical methods. These novel methodologies not only benefit from the formation of highly functionalized products bearing both synthetically versatile boronic ester and amino moieties, but also lay solid foundations for the development of this new field. Based on the significant antibacterial activity against Mycobacterium tuberculosis of β-amino boronic acids, a preliminary test of the biological activities of compounds obtained throughout the proposed research (both cyclic and linear β-amino-boronic acids) will be carried out in collaboration with AstraZeneca. By combining two major fields of endeavour, new chemistry will emerge with unique structures harbouring novel properties for exploitation. Furthermore this project will enable significant knowledge transfer between host and researcher, while forging new academic networks within the scientific community.

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The information about "NEWBORN" are provided by the European Opendata Portal: CORDIS opendata.

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