Opendata, web and dolomites


Deciphering the role of astrocytes in chronic depression.

Total Cost €


EC-Contrib. €






 ASTRO_ECM project word cloud

Explore the words cloud of the ASTRO_ECM project. It provides you a very rough idea of what is the project "ASTRO_ECM" about.

matrix    organization    dys    impairment    astrocytes    molecular    designer    released    function    alike    dreadds    hippocampus    disorder    model    employ    chronic    largely    social    vs    coordinated    depressive    genetically    disrupted    activated    assisted    astrocytic    expression    inadequate    depressed    interventions    people    genes    primarily    demonstrated    therapeutic    subjected    options    treatment    engineered    composition    drugs    patients    astrocyte    uncover    induce    silencing    preclinical    depression    worldwide    viral    manifestation    vector    controls    debilitating    clinicians    relay    unknown    labeling    neurobiological    visualization    extracellular    cognitive    goals    cellular    integrative    efforts    synthesized    exclusively    physiology    behavioural    despite    unravel    ameliorate    alters    pathophysiology    suggests    ecm    psychiatric    metabolic    assembly    receptor    mice    first    substrates    alterations    valid    proteome    mediating    establishing    modulation    defeat    molecules    contribution    morphology   

Project "ASTRO_ECM" data sheet

The following table provides information about the project.


Organization address
city: BONN
postcode: 53127

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Depression is a debilitating psychiatric disorder that affects 1 in 7 people worldwide. Despite coordinated efforts from researchers and clinicians alike, the neurobiological substrates of depression remain largely unknown. As a result, therapeutic options against depression are inadequate. Using a valid preclinical model, I recently demonstrated that depression alters the molecular composition of astrocytes and the organization of extracellular matrix (ECM), an assembly of molecules that are primarily synthesized and released by astrocytes. This results in disrupted information relay in the hippocampus and in cognitive impairment, both commonly seen in depressed patients. Thus, my work suggests a role of astrocytic (dys)function in the depressive state. In the proposed project, I aim to unravel the contribution of astrocytes in the pathophysiology of depression. First, I will address how the depressive state affects astrocyte proteome, morphology and function. Second, I will address the role of astrocytes and astrocyte-derived ECM in the manifestation of depression at the molecular, cellular and the behavioural level. To reach my goals, I will make use of genetically engineered mice that allow for visualization, metabolic labeling and targeting of astrocytes. These mice will be subjected to social defeat to induce a chronic depressive state. I will study astrocyte morphology, physiology and proteome alterations in depressed mice vs. controls. After establishing astrocyte-specific changes, I will employ i) viral vector-assisted silencing of the expression of astrocytic genes contributing to the ECM and ii) designer receptor exclusively activated by designer drugs (DREADDs)-assisted modulation of astrocyte activity. I will then assess whether these interventions can ameliorate the depressive state. With this integrative approach I aim to uncover novel molecular pathways mediating the depressive state and to identify new targets for the treatment of depression.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASTRO_ECM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASTRO_ECM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

FreeDigital (2019)

The impact of 'free' digital offers on individual behavior and its implications for consumer and data protection laws

Read More  

QoSIoTSmartCities (2019)

Quality of Service for the Internet of Things in Smart Cities via Predictive Networks

Read More  

COMLIB (2019)

Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in Poland

Read More