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NanoFEITH SIGNED

Nanoparticles for Fluorescence-Enhanced Imaging and Therapy of Breast Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoFEITH project word cloud

Explore the words cloud of the NanoFEITH project. It provides you a very rough idea of what is the project "NanoFEITH" about.

carrier    fluorescence    ph    gold    expertise    core    tumour    minimize    multidisciplinary    combined    vitro    tips    imaging    surface    cancer    ineffective    near    platforms    bc    au    responsive    passive    advantages    computational    vs    3d    therapeutic    promise    therapy    nanoparticles    np    fluorescent    lids    nps    women    nanobipyramids    translation    limited    mef    bearing    sensitivity    coating    active    nanotechnology    skills    infrared    resolution    diagnosis    personalized    complement    signals    strategy    mitigating    toward    enhancement    vital    international    site    cultures    paving    combine    optical    multimodal    treatment    accumulation    materials    complementary    biodistribution    metal    release    worldwide    science    vivo    coordinated    tunable    theranostic    maturity    systemic    zn    first    dyes    combining    dramatically    elongated    chemotherapeutic    nanomedicine    detection    offers    photothermal    biocompatibility    mortality    efficacy    clinical    resistant    sizes    professional    ion    insights    host    spatial    death    drug    modalities    techniques    enhanced    sharp    cell    training    collaborations    treating    nir    breast    tumours    time   

Project "NanoFEITH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Breast cancer (BC) represents a leading cause of cancer-related death in women worldwide, in large part due to ineffective detection and treatment. Nanotechnology offers new promise in mitigating BC mortality, by combining therapy with early diagnosis in “theranostic” nanoparticles (NPs). Here, a multidisciplinary approach is proposed to develop and evaluate novel theranostic NPs, which for the first time combine near infrared (NIR) metal-enhanced fluorescence (MEF) imaging with multimodal cancer treatment. MEF is a promising strategy for dramatically improving the low fluorescent signals of available NIR dyes, but limited MEF platforms for in vivo applications have been developed. Here, elongated gold (Au) NPs (nanobipyramids) with two sharp tips and tunable sizes/optical properties are expected to provide distinct advantages, including large fluorescence enhancement and increased tumour accumulation, thus enabling real-time in vivo imaging with high sensitivity and spatial resolution. Furthermore, BC photothermal therapy by the Au core will be combined with a chemotherapeutic drug-carrier surface coating, bearing pH-responsive lids to allow controlled drug and Zn ion release at the tumour site. Coordinated use of these modalities is expected to minimize systemic side effects, improve therapeutic efficacy and be useful in treating drug resistant tumours. Several complementary techniques, including computational modelling, 3D in vitro cell cultures, in vivo testing and advanced 3D imaging will be combined to characterize NP biodistribution, biocompatibility and passive vs. active tumour targeting. These will provide vital insights for the – still challenging – clinical translation of NPs in general, paving the way toward personalized nanomedicine. The proposed research/training will complement the Applicant’s skills in materials science with the Host’s expertise in cancer drug delivery to enhance his professional maturity and promote international collaborations.

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