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NanoFEITH SIGNED

Nanoparticles for Fluorescence-Enhanced Imaging and Therapy of Breast Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoFEITH project word cloud

Explore the words cloud of the NanoFEITH project. It provides you a very rough idea of what is the project "NanoFEITH" about.

tunable    cultures    sizes    combined    systemic    fluorescent    treatment    vivo    mortality    promise    nanoparticles    ineffective    photothermal    science    site    collaborations    diagnosis    women    gold    vitro    theranostic    core    bearing    translation    enhanced    complement    3d    drug    materials    biodistribution    lids    expertise    host    toward    efficacy    sensitivity    dramatically    training    np    nanobipyramids    elongated    fluorescence    cell    advantages    therapy    spatial    near    breast    chemotherapeutic    vital    offers    worldwide    clinical    surface    infrared    accumulation    techniques    skills    nanotechnology    dyes    enhancement    nps    combine    multidisciplinary    computational    coordinated    responsive    international    tumours    vs    death    tumour    time    optical    nanomedicine    bc    release    nir    combining    minimize    biocompatibility    professional    au    passive    limited    personalized    cancer    signals    sharp    ion    zn    ph    paving    resistant    maturity    metal    tips    insights    platforms    carrier    mitigating    complementary    imaging    resolution    treating    active    multimodal    first    therapeutic    modalities    mef    strategy    detection    coating   

Project "NanoFEITH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Breast cancer (BC) represents a leading cause of cancer-related death in women worldwide, in large part due to ineffective detection and treatment. Nanotechnology offers new promise in mitigating BC mortality, by combining therapy with early diagnosis in “theranostic” nanoparticles (NPs). Here, a multidisciplinary approach is proposed to develop and evaluate novel theranostic NPs, which for the first time combine near infrared (NIR) metal-enhanced fluorescence (MEF) imaging with multimodal cancer treatment. MEF is a promising strategy for dramatically improving the low fluorescent signals of available NIR dyes, but limited MEF platforms for in vivo applications have been developed. Here, elongated gold (Au) NPs (nanobipyramids) with two sharp tips and tunable sizes/optical properties are expected to provide distinct advantages, including large fluorescence enhancement and increased tumour accumulation, thus enabling real-time in vivo imaging with high sensitivity and spatial resolution. Furthermore, BC photothermal therapy by the Au core will be combined with a chemotherapeutic drug-carrier surface coating, bearing pH-responsive lids to allow controlled drug and Zn ion release at the tumour site. Coordinated use of these modalities is expected to minimize systemic side effects, improve therapeutic efficacy and be useful in treating drug resistant tumours. Several complementary techniques, including computational modelling, 3D in vitro cell cultures, in vivo testing and advanced 3D imaging will be combined to characterize NP biodistribution, biocompatibility and passive vs. active tumour targeting. These will provide vital insights for the – still challenging – clinical translation of NPs in general, paving the way toward personalized nanomedicine. The proposed research/training will complement the Applicant’s skills in materials science with the Host’s expertise in cancer drug delivery to enhance his professional maturity and promote international collaborations.

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