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NanoFEITH SIGNED

Nanoparticles for Fluorescence-Enhanced Imaging and Therapy of Breast Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoFEITH project word cloud

Explore the words cloud of the NanoFEITH project. It provides you a very rough idea of what is the project "NanoFEITH" about.

multidisciplinary    multimodal    vivo    skills    mortality    dyes    nanoparticles    complementary    enhancement    metal    signals    biocompatibility    chemotherapeutic    toward    limited    clinical    cell    sensitivity    treatment    optical    tumours    elongated    fluorescent    release    fluorescence    imaging    minimize    dramatically    photothermal    resolution    3d    nanotechnology    au    vital    efficacy    complement    platforms    lids    host    cultures    coordinated    bc    insights    personalized    nir    spatial    promise    first    ineffective    site    materials    passive    active    sharp    science    responsive    vs    cancer    death    resistant    translation    combine    ion    tunable    worldwide    nanomedicine    breast    detection    systemic    training    ph    collaborations    mitigating    vitro    techniques    therapeutic    treating    advantages    combined    modalities    infrared    sizes    time    tips    computational    drug    enhanced    therapy    mef    gold    nps    coating    surface    accumulation    strategy    combining    theranostic    paving    near    women    bearing    diagnosis    offers    tumour    professional    np    zn    carrier    core    expertise    biodistribution    nanobipyramids    international    maturity   

Project "NanoFEITH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Breast cancer (BC) represents a leading cause of cancer-related death in women worldwide, in large part due to ineffective detection and treatment. Nanotechnology offers new promise in mitigating BC mortality, by combining therapy with early diagnosis in “theranostic” nanoparticles (NPs). Here, a multidisciplinary approach is proposed to develop and evaluate novel theranostic NPs, which for the first time combine near infrared (NIR) metal-enhanced fluorescence (MEF) imaging with multimodal cancer treatment. MEF is a promising strategy for dramatically improving the low fluorescent signals of available NIR dyes, but limited MEF platforms for in vivo applications have been developed. Here, elongated gold (Au) NPs (nanobipyramids) with two sharp tips and tunable sizes/optical properties are expected to provide distinct advantages, including large fluorescence enhancement and increased tumour accumulation, thus enabling real-time in vivo imaging with high sensitivity and spatial resolution. Furthermore, BC photothermal therapy by the Au core will be combined with a chemotherapeutic drug-carrier surface coating, bearing pH-responsive lids to allow controlled drug and Zn ion release at the tumour site. Coordinated use of these modalities is expected to minimize systemic side effects, improve therapeutic efficacy and be useful in treating drug resistant tumours. Several complementary techniques, including computational modelling, 3D in vitro cell cultures, in vivo testing and advanced 3D imaging will be combined to characterize NP biodistribution, biocompatibility and passive vs. active tumour targeting. These will provide vital insights for the – still challenging – clinical translation of NPs in general, paving the way toward personalized nanomedicine. The proposed research/training will complement the Applicant’s skills in materials science with the Host’s expertise in cancer drug delivery to enhance his professional maturity and promote international collaborations.

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