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ART-BONE SIGNED

Manufacturing of Artificial Bone for Repair and Regeneration of Large Osseous Defects

Total Cost €

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EC-Contrib. €

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Partnership

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 ART-BONE project word cloud

Explore the words cloud of the ART-BONE project. It provides you a very rough idea of what is the project "ART-BONE" about.

helium    native    strategy    3d    osteoconduction    materials    biomineralization    respect    latest    synthetic    good    molecules    inflammation    ion    elementary    biomaterial    physical    techniques    pairs    experiment    architecture    inflammatory    guarantee    precisely    reconstruct    capability    biomaterials    adjusted    water    theory    insure    parallel    repair    hydroxyapatite    autografts    optimal    alternative    combined    crystals    clinical    fibrils    innovative    bioorganic    tissue    chemical    nanotechnology    overcome    active    gold    characterization    finalized    accordingly    bone    magnetic    osseointegration    limitations    biomimicry    building    spectroscopy    biocompatibility    biomimetic    possesses    standard    manufacturing    cryogenic    prevent    fact    nuclear    differ    surrounding    structural    scanning    osteointegration    collagen    inspired    electron    composition    resonance    resides    implantation    novelty    capacity    adhesion    microscopy    natural    transmission    appealing    printing    blocks    solid    scrutinize    regeneration    tissues    possess    experimental    mimics    implant    suboptimal   

Project "ART-BONE" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Implant biomaterials currently used for bone repair and regeneration often cause inflammation responses, and possess suboptimal osseointegration capability and osteoconduction ability. These significant clinical problems are due to their chemical, structural and physical properties which differ greatly with respect to a natural bone tissue. ART-BONE aims to overcome these limitations via an innovative, nanotechnology strategy for the manufacturing of a new type of synthetic biomaterial that precisely mimics bone tissue features. This strategy pairs 3D printing technology with a bottom-up process in which the elementary building blocks of bone (hydroxyapatite crystals, collagen fibrils, water molecules, active bioorganic molecules) are combined to reconstruct the overall architecture and chemical composition of a natural bone tissue. In parallel, numerous materials characterization techniques (solid-state nuclear magnetic resonance spectroscopy, scanning helium ion microscopy, cryogenic transmission electron microscopy, etc.) will be applied to scrutinize the finalized synthetic biomaterial; and the experiment conditions will be adjusted accordingly to ensure its biomimicry with native tissues. The novelty of this strategy resides in the fact that the experimental approach is inspired by the latest concepts in bone biomineralization, and enables the design of highly biomimetic, synthetic biomaterials in terms of chemical, structural and physical properties. This strategy must not only guarantee the biocompatibility of the finalized synthetic biomaterial and prevent inflammatory responses, but also insure a good adhesion to the surrounding bone tissue following implantation. Such highly biomimetic, synthetic biomaterial possesses, in theory, optimal osteointegration capacity and osteoconduction ability, and will offer an appealing alternative to the clinical “gold standard” autografts in the future.

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The information about "ART-BONE" are provided by the European Opendata Portal: CORDIS opendata.

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