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ART-BONE SIGNED

Manufacturing of Artificial Bone for Repair and Regeneration of Large Osseous Defects

Total Cost €

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EC-Contrib. €

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Partnership

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 ART-BONE project word cloud

Explore the words cloud of the ART-BONE project. It provides you a very rough idea of what is the project "ART-BONE" about.

resides    collagen    clinical    differ    biocompatibility    latest    structural    adhesion    tissue    implantation    materials    biomaterials    osseointegration    molecules    novelty    transmission    combined    repair    nanotechnology    building    regeneration    appealing    precisely    bone    biomineralization    resonance    composition    mimics    gold    scrutinize    insure    implant    surrounding    pairs    natural    cryogenic    microscopy    solid    synthetic    reconstruct    biomimicry    active    fact    scanning    bioorganic    respect    possess    characterization    electron    tissues    optimal    hydroxyapatite    printing    osteoconduction    guarantee    chemical    limitations    strategy    blocks    physical    suboptimal    alternative    experiment    inflammation    adjusted    capacity    nuclear    finalized    prevent    autografts    good    crystals    native    innovative    helium    standard    theory    overcome    inflammatory    inspired    fibrils    architecture    water    spectroscopy    accordingly    osteointegration    ion    techniques    manufacturing    biomaterial    parallel    possesses    elementary    capability    biomimetic    3d    experimental    magnetic   

Project "ART-BONE" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Implant biomaterials currently used for bone repair and regeneration often cause inflammation responses, and possess suboptimal osseointegration capability and osteoconduction ability. These significant clinical problems are due to their chemical, structural and physical properties which differ greatly with respect to a natural bone tissue. ART-BONE aims to overcome these limitations via an innovative, nanotechnology strategy for the manufacturing of a new type of synthetic biomaterial that precisely mimics bone tissue features. This strategy pairs 3D printing technology with a bottom-up process in which the elementary building blocks of bone (hydroxyapatite crystals, collagen fibrils, water molecules, active bioorganic molecules) are combined to reconstruct the overall architecture and chemical composition of a natural bone tissue. In parallel, numerous materials characterization techniques (solid-state nuclear magnetic resonance spectroscopy, scanning helium ion microscopy, cryogenic transmission electron microscopy, etc.) will be applied to scrutinize the finalized synthetic biomaterial; and the experiment conditions will be adjusted accordingly to ensure its biomimicry with native tissues. The novelty of this strategy resides in the fact that the experimental approach is inspired by the latest concepts in bone biomineralization, and enables the design of highly biomimetic, synthetic biomaterials in terms of chemical, structural and physical properties. This strategy must not only guarantee the biocompatibility of the finalized synthetic biomaterial and prevent inflammatory responses, but also insure a good adhesion to the surrounding bone tissue following implantation. Such highly biomimetic, synthetic biomaterial possesses, in theory, optimal osteointegration capacity and osteoconduction ability, and will offer an appealing alternative to the clinical “gold standard” autografts in the future.

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The information about "ART-BONE" are provided by the European Opendata Portal: CORDIS opendata.

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