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GAE SIGNED

Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammal

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GAE project word cloud

Explore the words cloud of the GAE project. It provides you a very rough idea of what is the project "GAE" about.

architecture    roles    oxidative    economic    genes    opportunity    populations    insurance    traits    ferrare    genomics    impossible    genetic    fascinating    behavioural    special    ageing    reproductive    avoidance    lived    tp53    size    determinants    disentangle    shortening    health    balance    thousands    history    biological    host    post    asian    proboscideans    explored    century    skills    competences    mitigate    prof    life    mammals    secondment    model    function    adaptations    contrary    university    lack    insights    hereditary    respect    longevity    trade    exempt    genomic    phenomenon    edge    turku    menopause    records    team    models    almost    cutting    cell    human    individual    international    elephants    predictions    bertorelle    retrocopies    possibly    social    age    humans    telomere    multiple    fertility    understand    dataset    off    ecophysiology    explore    grandmotherhood    lifespan    mitochondrial    senescence    cancer    argument    faces    stress    yield    disciplinary    lummaa    ecology   

Project "GAE" data sheet

The following table provides information about the project.

Coordinator
TURUN YLIOPISTO 

Organization address
address: YLIOPISTONMAKI
city: Turku
postcode: 20014
website: www.utu.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 179˙325 €
 EC max contribution 179˙325 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TURUN YLIOPISTO FI (Turku) coordinator 179˙325.00

Map

 Project objective

'European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of 'biological age', and in particular its genetic determinants. It is now established that longevity insurance genes such as TP53 mitigate the roles of mitochondrial function, oxidative stress and telomere shortening, and that these genes are also involved in ageing, with senescence and cancer being two faces of the cell growth balance. Thus, longevity is a trade-off between cancer and ageing, but also possibly fertility and menopause. In that respect, Asian elephants are a fascinating model: similar to humans in lifespan, senescence, and selection for grandmotherhood, they are almost exempt of cancer, contrary to predictions based on their large size. Recently, multiple retrocopies of TP53 have been identified in elephants: a strong argument to consider that cancer-avoidance and a long lifespan are the product of genetic adaptations in proboscideans. The genetic architecture of human-like ageing is impossible to study in classical short-lived models, as they lack the traits that make human life-history special, like a post-reproductive lifespan. Therefore, I propose to use a unique century-long dataset on life-history and health records for thousands of Asian elephants, currently explored by Prof. Lummaa's international-level team through behavioural ecology and ecophysiology at University of Turku. Together with my secondment host Prof. Bertorelle at University of Ferrare, I will apply my skills in cutting-edge genomic methods to disentangle the hereditary and individual determinants of ageing in long-lived mammals. By bringing these different competences together on a one-of-its-kind dataset, I will exploit this unique and exciting opportunity to explore the genomics of senescence through a multi-disciplinary approach, which may yield important insights for understanding human ageing.'

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The information about "GAE" are provided by the European Opendata Portal: CORDIS opendata.

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