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GAE SIGNED

Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammal

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 GAE project word cloud

Explore the words cloud of the GAE project. It provides you a very rough idea of what is the project "GAE" about.

cancer    life    lifespan    traits    longevity    century    secondment    mammals    records    mitigate    mitochondrial    genomics    asian    tp53    telomere    lack    cell    retrocopies    explore    populations    cutting    individual    ecology    economic    possibly    edge    social    ageing    reproductive    age    humans    competences    genes    avoidance    fertility    university    respect    health    trade    roles    impossible    architecture    predictions    genetic    host    team    disciplinary    shortening    biological    ecophysiology    thousands    yield    model    genomic    dataset    turku    human    models    ferrare    off    bertorelle    understand    insights    phenomenon    proboscideans    argument    balance    behavioural    function    grandmotherhood    faces    size    special    determinants    international    insurance    fascinating    opportunity    disentangle    almost    elephants    skills    history    lummaa    prof    hereditary    oxidative    exempt    explored    multiple    post    contrary    menopause    stress    adaptations    senescence    lived   

Project "GAE" data sheet

The following table provides information about the project.

Coordinator
TURUN YLIOPISTO 

Organization address
address: YLIOPISTONMAKI
city: Turku
postcode: 20014
website: www.utu.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 179˙325 €
 EC max contribution 179˙325 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TURUN YLIOPISTO FI (Turku) coordinator 179˙325.00

Map

 Project objective

'European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of 'biological age', and in particular its genetic determinants. It is now established that longevity insurance genes such as TP53 mitigate the roles of mitochondrial function, oxidative stress and telomere shortening, and that these genes are also involved in ageing, with senescence and cancer being two faces of the cell growth balance. Thus, longevity is a trade-off between cancer and ageing, but also possibly fertility and menopause. In that respect, Asian elephants are a fascinating model: similar to humans in lifespan, senescence, and selection for grandmotherhood, they are almost exempt of cancer, contrary to predictions based on their large size. Recently, multiple retrocopies of TP53 have been identified in elephants: a strong argument to consider that cancer-avoidance and a long lifespan are the product of genetic adaptations in proboscideans. The genetic architecture of human-like ageing is impossible to study in classical short-lived models, as they lack the traits that make human life-history special, like a post-reproductive lifespan. Therefore, I propose to use a unique century-long dataset on life-history and health records for thousands of Asian elephants, currently explored by Prof. Lummaa's international-level team through behavioural ecology and ecophysiology at University of Turku. Together with my secondment host Prof. Bertorelle at University of Ferrare, I will apply my skills in cutting-edge genomic methods to disentangle the hereditary and individual determinants of ageing in long-lived mammals. By bringing these different competences together on a one-of-its-kind dataset, I will exploit this unique and exciting opportunity to explore the genomics of senescence through a multi-disciplinary approach, which may yield important insights for understanding human ageing.'

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The information about "GAE" are provided by the European Opendata Portal: CORDIS opendata.

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