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GAE SIGNED

Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammal

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GAE project word cloud

Explore the words cloud of the GAE project. It provides you a very rough idea of what is the project "GAE" about.

genomics    competences    tp53    trade    balance    telomere    insights    almost    ecophysiology    records    special    determinants    models    dataset    cutting    human    traits    disciplinary    architecture    fertility    understand    asian    biological    mitochondrial    senescence    contrary    off    elephants    age    proboscideans    prof    team    life    genetic    faces    argument    avoidance    secondment    ecology    explored    ferrare    adaptations    fascinating    reproductive    predictions    social    respect    international    longevity    mammals    grandmotherhood    mitigate    shortening    humans    turku    post    impossible    size    menopause    exempt    hereditary    history    edge    cell    oxidative    function    phenomenon    thousands    university    individual    explore    yield    disentangle    stress    century    genomic    cancer    retrocopies    insurance    host    lummaa    lack    genes    model    lived    lifespan    populations    behavioural    health    economic    roles    multiple    opportunity    possibly    skills    ageing    bertorelle   

Project "GAE" data sheet

The following table provides information about the project.

Coordinator
TURUN YLIOPISTO 

Organization address
address: YLIOPISTONMAKI
city: Turku
postcode: 20014
website: www.utu.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 179˙325 €
 EC max contribution 179˙325 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TURUN YLIOPISTO FI (Turku) coordinator 179˙325.00

Map

 Project objective

'European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of 'biological age', and in particular its genetic determinants. It is now established that longevity insurance genes such as TP53 mitigate the roles of mitochondrial function, oxidative stress and telomere shortening, and that these genes are also involved in ageing, with senescence and cancer being two faces of the cell growth balance. Thus, longevity is a trade-off between cancer and ageing, but also possibly fertility and menopause. In that respect, Asian elephants are a fascinating model: similar to humans in lifespan, senescence, and selection for grandmotherhood, they are almost exempt of cancer, contrary to predictions based on their large size. Recently, multiple retrocopies of TP53 have been identified in elephants: a strong argument to consider that cancer-avoidance and a long lifespan are the product of genetic adaptations in proboscideans. The genetic architecture of human-like ageing is impossible to study in classical short-lived models, as they lack the traits that make human life-history special, like a post-reproductive lifespan. Therefore, I propose to use a unique century-long dataset on life-history and health records for thousands of Asian elephants, currently explored by Prof. Lummaa's international-level team through behavioural ecology and ecophysiology at University of Turku. Together with my secondment host Prof. Bertorelle at University of Ferrare, I will apply my skills in cutting-edge genomic methods to disentangle the hereditary and individual determinants of ageing in long-lived mammals. By bringing these different competences together on a one-of-its-kind dataset, I will exploit this unique and exciting opportunity to explore the genomics of senescence through a multi-disciplinary approach, which may yield important insights for understanding human ageing.'

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The information about "GAE" are provided by the European Opendata Portal: CORDIS opendata.

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