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Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammal

Total Cost €


EC-Contrib. €






 GAE project word cloud

Explore the words cloud of the GAE project. It provides you a very rough idea of what is the project "GAE" about.

skills    understand    mammals    longevity    genetic    hereditary    records    prof    genomic    international    mitochondrial    architecture    cancer    ecophysiology    adaptations    host    mitigate    possibly    turku    multiple    predictions    biological    special    telomere    explore    tp53    disciplinary    impossible    individual    health    competences    menopause    model    explored    retrocopies    contrary    insights    ecology    models    edge    humans    economic    history    lifespan    insurance    lummaa    life    university    faces    balance    genes    argument    trade    function    cell    oxidative    avoidance    age    thousands    exempt    grandmotherhood    dataset    secondment    off    bertorelle    stress    respect    ageing    asian    fertility    phenomenon    senescence    disentangle    fascinating    opportunity    century    size    yield    almost    roles    ferrare    behavioural    genomics    determinants    elephants    team    human    populations    cutting    social    traits    post    shortening    lived    reproductive    proboscideans    lack   

Project "GAE" data sheet

The following table provides information about the project.


Organization address
city: Turku
postcode: 20014

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 179˙325 €
 EC max contribution 179˙325 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TURUN YLIOPISTO FI (Turku) coordinator 179˙325.00


 Project objective

'European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of 'biological age', and in particular its genetic determinants. It is now established that longevity insurance genes such as TP53 mitigate the roles of mitochondrial function, oxidative stress and telomere shortening, and that these genes are also involved in ageing, with senescence and cancer being two faces of the cell growth balance. Thus, longevity is a trade-off between cancer and ageing, but also possibly fertility and menopause. In that respect, Asian elephants are a fascinating model: similar to humans in lifespan, senescence, and selection for grandmotherhood, they are almost exempt of cancer, contrary to predictions based on their large size. Recently, multiple retrocopies of TP53 have been identified in elephants: a strong argument to consider that cancer-avoidance and a long lifespan are the product of genetic adaptations in proboscideans. The genetic architecture of human-like ageing is impossible to study in classical short-lived models, as they lack the traits that make human life-history special, like a post-reproductive lifespan. Therefore, I propose to use a unique century-long dataset on life-history and health records for thousands of Asian elephants, currently explored by Prof. Lummaa's international-level team through behavioural ecology and ecophysiology at University of Turku. Together with my secondment host Prof. Bertorelle at University of Ferrare, I will apply my skills in cutting-edge genomic methods to disentangle the hereditary and individual determinants of ageing in long-lived mammals. By bringing these different competences together on a one-of-its-kind dataset, I will exploit this unique and exciting opportunity to explore the genomics of senescence through a multi-disciplinary approach, which may yield important insights for understanding human ageing.'

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The information about "GAE" are provided by the European Opendata Portal: CORDIS opendata.

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