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TFs-HSCs

The identification of the Combinatorial Transcription Factor network exerting different roles in Hematopoietic Stem Cells.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TFs-HSCs project word cloud

Explore the words cloud of the TFs-HSCs project. It provides you a very rough idea of what is the project "TFs-HSCs" about.

screenings    independent    genetic    molecular    extracellular    leukemic    organization    first    broaden    1391    t2c    malignancy    uncharacterized    blood    successful    acute    prof    generating    transcriptional    hscs    hcss    insights    transcription    420    notably    patients    data    regulate    myeloid    until    assisting    proliferation    researcher    treating    acquiring    wp3    skills    expertise    helin    career    vitro    network    genome    strengthen    poor    world    vivo    cas9    progressing    encode    wp1    accomplishment    regulation    22000    levels    hematopoiesis    rate    funnelled    contains    tf    builds    mature    differentiation    architecture    environment    effect    stem    cells    cancer    functional    prognosis    unravel    outcome    genes    transferable    aml    bric    survival    crispr    regulated    cellular    lab    generation    expressed    tfs    hematopoietic    estimating    wp2    biology    chromatin    human    signals    regulating    extensive    intracellular    expert    progression    deciphering   

Project "TFs-HSCs" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/Helin_Group/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Deciphering the TF network regulating hematopoietic stem cells (HSCs) would be important in treating acute myeloid leukemic (AML) patients; a rapidly progressing hematopoietic malignancy with poor prognosis and survival rate. Hematopoiesis is the process of generating all the mature blood cells from HSCs. Its regulation is, even until now, not fully understood and studied in all its levels. HCSs and hematopoietic differentiation are the key elements that are regulated by the cellular environment (extracellular/intracellular signals) funnelled into transcription factors (TFs). Notably, the human genome contains ~22000 genes estimating to encode 1391 TFs. I have already identified 420 TFs expressed in HSCs. Until now 20-30 TFs have been well-characterized in hematopoiesis, and my aim is to identify the role of the uncharacterized TFs required for hematopoiesis. First I will identify which of the 420 TFs have an effect in HSCs in vitro (WP1). Then I will test in vivo, if the TFs identified in vitro will affect hematopoiesis (WP2). Finally, I will investigate the functional properties of the selected TFs and unravel their role in chromatin organization and regulation of hematopoiesis (WP3). For all this, I will use novel state of the art methods like CRISPR/Cas9 and T2C. The accomplishment of my aims will provide new insights into how TFs regulate the generation/proliferation of HSCs. The proposal builds on my experience in data analysis, transcriptional regulation, chromatin architecture and the unique resources available at BRIC. Prof Helin, a world leading expert in hematopoiesis and cancer, and his lab have extensive experience on genetic screenings and molecular biology ensuring a successful outcome. Through this project, I aim to broaden/strengthen my expertise by acquiring the necessary technical/transferable skills assisting my future career progression to an independent researcher in the fields of molecular biology, chromatin architecture and hematopoiesis.

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