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EpiBarrier SIGNED

Control of the blood-brain barrier integrity during seizures via the ATP-gated P2X7 receptor

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiBarrier project word cloud

Explore the words cloud of the EpiBarrier project. It provides you a very rough idea of what is the project "EpiBarrier" about.

gated    disease    responsiveness    drugs    seizure    cns    anti    inflammatory    cells    decade    barrier    damaging    cutting    million    toxic    molecules    inflammation    transgenic    chronic    models    pertinent    emphasis    immune    strategies    entry    vasculature    network    maintaining    rna    interleukin    epilepsy    people    continuous    atp    earliest    disturbances    sequencing    play    downstream       purinergic    brain    effect    blood    gained    integrity    bbb    techniques    cerebral    cellular    treatment    status    50    pathology    progression    players    pathophysiological    separating    imaging    cell    types    genes    protects    consequently    newly    neurological    beta    borne    ing    hemorrhage    intracerebral    prevent    epilepticus    opening    receptor    dysfunction    epileptogenesis    expressed    antagonism    p2x7    disruption    homeostasis    seizures    functional    impacts    endothelial    disorder    animal    compounds    forming    regulated    signaling    leakage    function    epileptogenic    epileptic    permeability    dependent    paid    date    bloodstream    edge   

Project "EpiBarrier" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Epilepsy is the most common chronic neurological disorder, affecting ~50 million people. Major challenges in epilepsy include non-responsiveness to treatment and no effect on disease progression provided by anti-epileptic drugs. Over the past decade, particular attention has been paid to dysfunction of cerebral vasculature and inflammatory processes as important players in epileptogenic processes, with a specific emphasis on failure of the blood–brain barrier (BBB). The BBB is a complex cellular network forming a continuous cellular barrier separating the CNS from the bloodstream. A functional BBB is crucial in maintaining brain homeostasis and to prevent the entry of toxic compounds and immune cells into the CNS. During pathology, however, the permeability of the BBB may increase with the resulting entry into the CNS of blood-borne molecules and cells. Leakage of the BBB is one of the earliest characteristic pathophysiological disturbances following status epilepticus and may play an important role in the development of epilepsy. Consequently, drugs targeting BBB function may represent novel treatment strategies in epilepsy. The purinergic ATP-gated P2X7 receptor has gained much attention recently as novel target in the treatment of epilepsy. Expressed on all cell types in the CNS including endothelial cells, P2X7 has been associated with numerous damaging processes pertinent to epileptogenesis, such as inflammation and opening of the BBB. ATP and the P2X7 downstream target Interleukin-1β contribute to the disruption of the BBB and P2X7 antagonism protects against BBB disruption during intracerebral hemorrhage. To date, however, we do not know whether seizure-induced changes of the BBB are dependent on P2X7 signaling, and whether this process can be targeted. By using newly developed transgenic animal models, RNA sequencing and cutting edge imaging techniques we will determine how P2X7 impacts on BBB integrity during seizures and what genes are regulated by P2X7.

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