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EpiBarrier SIGNED

Control of the blood-brain barrier integrity during seizures via the ATP-gated P2X7 receptor

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiBarrier project word cloud

Explore the words cloud of the EpiBarrier project. It provides you a very rough idea of what is the project "EpiBarrier" about.

entry    beta    function    continuous    network    maintaining    dependent    status    transgenic    edge    seizure    ing    vasculature    50    separating    endothelial    chronic    strategies    barrier    molecules    forming    expressed    anti    types    antagonism    leakage    compounds    functional    cns    gained    rna    cerebral    opening    imaging    immune    date    pertinent    regulated    pathology    techniques    pathophysiological       epileptic    inflammation    damaging    intracerebral    bbb    disorder    permeability    disease    cellular    epilepsy    decade    consequently    bloodstream    cells    p2x7    models    responsiveness    gated    integrity    atp    players    downstream    drugs    interleukin    neurological    treatment    animal    epileptogenesis    protects    progression    people    earliest    epilepticus    play    million    homeostasis    genes    receptor    cutting    paid    impacts    signaling    blood    effect    inflammatory    borne    cell    brain    sequencing    newly    dysfunction    seizures    disturbances    disruption    purinergic    epileptogenic    prevent    emphasis    toxic    hemorrhage   

Project "EpiBarrier" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Epilepsy is the most common chronic neurological disorder, affecting ~50 million people. Major challenges in epilepsy include non-responsiveness to treatment and no effect on disease progression provided by anti-epileptic drugs. Over the past decade, particular attention has been paid to dysfunction of cerebral vasculature and inflammatory processes as important players in epileptogenic processes, with a specific emphasis on failure of the blood–brain barrier (BBB). The BBB is a complex cellular network forming a continuous cellular barrier separating the CNS from the bloodstream. A functional BBB is crucial in maintaining brain homeostasis and to prevent the entry of toxic compounds and immune cells into the CNS. During pathology, however, the permeability of the BBB may increase with the resulting entry into the CNS of blood-borne molecules and cells. Leakage of the BBB is one of the earliest characteristic pathophysiological disturbances following status epilepticus and may play an important role in the development of epilepsy. Consequently, drugs targeting BBB function may represent novel treatment strategies in epilepsy. The purinergic ATP-gated P2X7 receptor has gained much attention recently as novel target in the treatment of epilepsy. Expressed on all cell types in the CNS including endothelial cells, P2X7 has been associated with numerous damaging processes pertinent to epileptogenesis, such as inflammation and opening of the BBB. ATP and the P2X7 downstream target Interleukin-1β contribute to the disruption of the BBB and P2X7 antagonism protects against BBB disruption during intracerebral hemorrhage. To date, however, we do not know whether seizure-induced changes of the BBB are dependent on P2X7 signaling, and whether this process can be targeted. By using newly developed transgenic animal models, RNA sequencing and cutting edge imaging techniques we will determine how P2X7 impacts on BBB integrity during seizures and what genes are regulated by P2X7.

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