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EpiBarrier SIGNED

Control of the blood-brain barrier integrity during seizures via the ATP-gated P2X7 receptor

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiBarrier project word cloud

Explore the words cloud of the EpiBarrier project. It provides you a very rough idea of what is the project "EpiBarrier" about.

anti    imaging    inflammatory    inflammation    cerebral    newly    borne    drugs    pertinent    decade    date    dysfunction    dependent    endothelial    blood    people    separating    cell    bbb    responsiveness    sequencing    ing    atp    models    receptor    players    chronic       techniques    homeostasis    gated    earliest    downstream    expressed    epilepticus    epileptogenic    molecules    strategies    opening    status    integrity    transgenic    damaging    entry    animal    regulated    play    intracerebral    hemorrhage    continuous    pathophysiological    interleukin    permeability    compounds    beta    disease    vasculature    cells    protects    consequently    disruption    immune    million    bloodstream    forming    paid    toxic    seizure    epileptic    impacts    edge    rna    function    maintaining    types    leakage    emphasis    gained    disturbances    50    seizures    effect    purinergic    pathology    cutting    epilepsy    cns    barrier    treatment    antagonism    p2x7    cellular    genes    signaling    brain    epileptogenesis    prevent    progression    disorder    network    functional    neurological   

Project "EpiBarrier" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

Epilepsy is the most common chronic neurological disorder, affecting ~50 million people. Major challenges in epilepsy include non-responsiveness to treatment and no effect on disease progression provided by anti-epileptic drugs. Over the past decade, particular attention has been paid to dysfunction of cerebral vasculature and inflammatory processes as important players in epileptogenic processes, with a specific emphasis on failure of the blood–brain barrier (BBB). The BBB is a complex cellular network forming a continuous cellular barrier separating the CNS from the bloodstream. A functional BBB is crucial in maintaining brain homeostasis and to prevent the entry of toxic compounds and immune cells into the CNS. During pathology, however, the permeability of the BBB may increase with the resulting entry into the CNS of blood-borne molecules and cells. Leakage of the BBB is one of the earliest characteristic pathophysiological disturbances following status epilepticus and may play an important role in the development of epilepsy. Consequently, drugs targeting BBB function may represent novel treatment strategies in epilepsy. The purinergic ATP-gated P2X7 receptor has gained much attention recently as novel target in the treatment of epilepsy. Expressed on all cell types in the CNS including endothelial cells, P2X7 has been associated with numerous damaging processes pertinent to epileptogenesis, such as inflammation and opening of the BBB. ATP and the P2X7 downstream target Interleukin-1β contribute to the disruption of the BBB and P2X7 antagonism protects against BBB disruption during intracerebral hemorrhage. To date, however, we do not know whether seizure-induced changes of the BBB are dependent on P2X7 signaling, and whether this process can be targeted. By using newly developed transgenic animal models, RNA sequencing and cutting edge imaging techniques we will determine how P2X7 impacts on BBB integrity during seizures and what genes are regulated by P2X7.

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