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COLOVOC SIGNED

Reliable and specific urinary biomarkers for colorectal cancer

Total Cost €

EC-Contrib. €

Partnership

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COLOVOC project word cloud

Explore the words cloud of the COLOVOC project. It provides you a very rough idea of what is the project "COLOVOC" about.

levels earlier colorectal year 10 discovery stage techniques equivalent ms qtof place screening stages clinical cancerous crc precursors gcxgx men invasiveness breast 100 diagnose orders validation detect urine collectible made cancer metastatic 50 frequency almost improvement patients readily subjects approaching confindent convenient manner gc ways women rates world prostate neoplastic twisters protocols polyps adult laboratory pathology diagnosis inhabitants mortality survival biofluid cure whereas metabolites diagnostics instrumentation 90 population approximately situation survivability sensitivity segregated de selectivity magnitude identification cohort collection hypothesis cancers central correlated economic rate lc regular biomarkers detection plays spme

Project "COLOVOC" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) Organization address address: CARRER ESCORXADOR city: TARRAGONA postcode: 43003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	257˙191 €
EC max contribution	257˙191 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-GF
Starting year	2019
Duration (year-month-day)	from 2019-07-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) Organization address address: CARRER ESCORXADOR city: TARRAGONA postcode: 43003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TARRAGONA)	coordinator	257˙191.00
2	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	partner	0.00

Map

Project objective

Colorectal cancer (CRC) is the most common neoplastic pathology in the developed world. It is the second in frequency in men after prostate cancer and the second in women after breast cancer. Survival at five years, if all stages are taken into account, is approximately 50%. That represents a mortality of 20 cases per 100,000 inhabitants per year. The five-year survival of early stages, a situation almost equivalent to cure, is approximately 90%, whereas in advanced or metastatic stages it is less than 10%. Therefore, early diagnosis plays a central role in the improvement of survival rates. The main goal of this project is to find new ways to detect the cancer in the very early stages. To do so, the sample collection must be as simple, economic and convenient as possible. Only in this manner, regular screening approaching 100% of adult population will take place. The approach we propose is the identification and validation of new biomarkers in urine that can be used to diagnose colorectal cancer (CRC) at a very early stage.

The central hypothesis is that CRC associated metabolites in the urine of patients can be segregated from patients with polyps (some of them precursors of CRC) and control subjects, and that their levels are correlated with clinical diagnostics of a CRC stage. Urine is an easy collectible biofluid for its non-invasiveness, and it can provide early detection of cancers. New sample measurement protocols and techniques are enhancing both selectivity and sensitivity by orders of magnitude, such as SPME and Twisters or GC/LC-MS systems (GCxGX/LC-QTOF-MS). The more sensitivity and selectivity, the more confindent diagnosis could be made at earlier stages of the cancerous process leading to a better survivability rate. Moreover, our proposal includes a multi-cohort, multi-laboratory validation of the findings, therefore ensuring that any discovery can readily be applied to any population and instrumentation around de world.

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The information about "COLOVOC" are provided by the European Opendata Portal: CORDIS opendata.