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Human Glymphatics SIGNED

Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Human Glymphatics project word cloud

Explore the words cloud of the Human Glymphatics project. It provides you a very rough idea of what is the project "Human Glymphatics" about.

preliminary    carvedilol    alzheimer    reduce    removal    imaging    secondly    career    skill    risks    amyloid    skills    fast    nevertheless    expertise    manipulation    neuropsychology    patient    sleep    experts    health    delay    fmri    disease    brain    first    host    distorted    perfectly    dependent    forms    severe    chosen    previously    drive    data    cognitive    rodents    aliasing    linked    hz    gs    ultra    function    flow    glymphatic    determinant    pulsations    adrenergic    macroscopic    independent    sufficient    demonstrating    human    analyzing    detection    beta    impairments    facilitates    metabolites    me    integrate    cardiac    foundation    slow    treating    antagonist    situated    mechanisms    disorders    mr    mri    neuroscience    exceptional    provides    time    completion    infrastructure    sequences    clearance    wakefulness    world    regulation    gf    noise    respiration    molecular    reveal    trait    neuroimaging   

Project "Human Glymphatics" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

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The information about "HUMAN GLYMPHATICS" are provided by the European Opendata Portal: CORDIS opendata.

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