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Human Glymphatics SIGNED

Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Human Glymphatics project word cloud

Explore the words cloud of the Human Glymphatics project. It provides you a very rough idea of what is the project "Human Glymphatics" about.

disorders    time    mr    provides    respiration    cognitive    nevertheless    metabolites    sequences    antagonist    secondly    forms    carvedilol    fmri    skills    gf    trait    detection    experts    regulation    previously    independent    reduce    adrenergic    molecular    severe    aliasing    dependent    removal    analyzing    human    disease    function    mri    neuroimaging    foundation    skill    gs    risks    impairments    perfectly    situated    brain    rodents    chosen    sufficient    pulsations    fast    beta    manipulation    macroscopic    sleep    cardiac    reveal    clearance    flow    imaging    delay    treating    patient    integrate    amyloid    data    alzheimer    world    host    expertise    glymphatic    distorted    preliminary    drive    completion    ultra    me    determinant    facilitates    exceptional    slow    first    health    linked    wakefulness    neuropsychology    infrastructure    career    noise    mechanisms    hz    neuroscience    demonstrating   

Project "Human Glymphatics" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

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The information about "HUMAN GLYMPHATICS" are provided by the European Opendata Portal: CORDIS opendata.

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