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Human Glymphatics SIGNED

Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Human Glymphatics project word cloud

Explore the words cloud of the Human Glymphatics project. It provides you a very rough idea of what is the project "Human Glymphatics" about.

mechanisms    exceptional    provides    foundation    beta    integrate    time    chosen    health    infrastructure    skills    demonstrating    disorders    data    trait    metabolites    pulsations    function    sleep    skill    neuropsychology    mr    secondly    nevertheless    amyloid    analyzing    completion    aliasing    experts    host    drive    flow    linked    dependent    cognitive    situated    respiration    forms    cardiac    mri    adrenergic    antagonist    preliminary    career    severe    first    noise    detection    sufficient    reveal    delay    gs    regulation    facilitates    world    perfectly    molecular    risks    determinant    alzheimer    slow    neuroimaging    previously    fast    sequences    wakefulness    distorted    human    hz    carvedilol    manipulation    disease    expertise    gf    patient    clearance    me    glymphatic    ultra    impairments    brain    fmri    macroscopic    reduce    imaging    treating    neuroscience    rodents    independent    removal   

Project "Human Glymphatics" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

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The information about "HUMAN GLYMPHATICS" are provided by the European Opendata Portal: CORDIS opendata.

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