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Human Glymphatics SIGNED

Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Human Glymphatics project word cloud

Explore the words cloud of the Human Glymphatics project. It provides you a very rough idea of what is the project "Human Glymphatics" about.

adrenergic    previously    me    impairments    data    foundation    expertise    human    career    aliasing    metabolites    world    linked    sleep    function    preliminary    skills    determinant    dependent    infrastructure    rodents    reveal    clearance    molecular    distorted    perfectly    mechanisms    drive    respiration    ultra    neuroscience    beta    first    sequences    flow    skill    alzheimer    cognitive    hz    amyloid    risks    regulation    experts    mr    secondly    imaging    detection    neuroimaging    time    wakefulness    treating    forms    reduce    exceptional    gs    gf    patient    analyzing    brain    glymphatic    sufficient    manipulation    fast    disease    independent    neuropsychology    slow    fmri    integrate    completion    trait    nevertheless    health    host    facilitates    demonstrating    mri    pulsations    disorders    macroscopic    provides    removal    antagonist    situated    chosen    carvedilol    delay    severe    noise    cardiac   

Project "Human Glymphatics" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

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The information about "HUMAN GLYMPHATICS" are provided by the European Opendata Portal: CORDIS opendata.

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