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MECHANOSITY SIGNED

Mechanical regulation of cellular behaviour in 3D viscoelastic materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECHANOSITY project word cloud

Explore the words cloud of the MECHANOSITY project. It provides you a very rough idea of what is the project "MECHANOSITY" about.

substrates    tissue    despite    molecules    transition    triggers    merely    clutch    microscopy    cancer    prevents    gene    machinery    predict    ecms    lines    gradients    extracellular    medicine    combined    clutches    experiments    influence    researcher    elosegui    biology    impairing    expression    2d    hydrogels    regenerative    predicted    microenvironments    regulate    predictions    translational    traction    cells    spheroids    performing    disciplines    ecm    reveal    alberto    understand    cellular    biomaterials    force    validated    hypothesize    vitro    emerged    single    mouse    molecular    epithelial    breast    elastic    mimicking    artola    transduction    techniques    matrix    dynamic    mesenchymal    intuitively    healthy    lastly    counter    model    3d    promoters    emt    matching    materials    tumour    viscoelasticity    viscoelastic    mechanical    tested    dimensional    cell    therapeutic    migration    organoids    sensing    formed    actin    relevance    observing    load    viscosity    interactions    malignant   

Project "MECHANOSITY" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 239˙191 €
 EC max contribution 239˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 239˙191.00
2    PRESIDENT AND FELLOWS OF HARVARD COLLEGE US (CAMBRIDGE) partner 0.00

Map

 Project objective

Extracellular matrix (ECM) mechanical properties have emerged as key promoters of processes such as cell migration and epithelial to mesenchymal transition (EMT) in cancer. Despite recent advances in the understanding of cellular ECM sensing machinery, mimicking tissue microenvironments in vitro is highly challenging, and most research has been focused on two dimensional (2D) elastic substrates. However, ECMs are not merely 2D elastic substrates, but rather viscoelastic three dimensional (3D) materials. Our objective is to understand how the viscoelastic properties of 3D ECMs regulate cell behaviour. We hypothesize that in viscoelastic materials, counter-intuitively, an increase in viscosity triggers force transduction and gene expression, due to an increase in the load of molecular clutches formed between the ECM and actin. To address the influence of viscoelasticity, Alberto Elosegui-Artola (the experienced researcher/ Applicant) will develop a set of hydrogels matching the viscoelastic properties of both healthy and malignant breast tissue. Then, traction force microscopy will be developed and combined with molecular biology techniques to determine the molecules involved in 3D viscoelasticity sensing. The dynamic behaviour of these molecules will be integrated in a 3D molecular clutch model with the aim to predict cellular migration and force transduction. Model predictions will be validated by performing experiments in 3D viscoelastic gradients on the migration of single cells and spheroids. Lastly, the relevance of the model will be tested by observing if impairing model-predicted force transduction elements prevents EMT transition in cell lines and mouse-derived breast healthy and tumour organoids. This project’s results are expected to reveal molecular interactions that could lead to new therapeutic targets in breast cancer, and also to provide translational opportunities in other disciplines including biomaterials and regenerative medicine.

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The information about "MECHANOSITY" are provided by the European Opendata Portal: CORDIS opendata.

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