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IN-3D-CAN SIGNED

Instrumented 3D-Printed Miniature Muscles for Cardiotoxicity Screens of Cancer Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 IN-3D-CAN project word cloud

Explore the words cloud of the IN-3D-CAN project. It provides you a very rough idea of what is the project "IN-3D-CAN" about.

instrumented    uni    perform    2d    cardiotoxicity    nanotech    career    am    antibody    cardiac    reported    independent    reintegrate    native    chemotherapeutics    paper    harvard    professorship    msca    expand    organs    host    abroad    screening    committed    cancer    3d    throughput    author    heart    introducing    engineered    dtu    nature    thicker    treatments    assistant    fatally    tracking    entirely    first    thin    printing    drugs    chips    printed    recurrent    organ    microphysiological    supervisor    toxicity    solution    patients    sensors    me    micro    techniques    muscle    materials    immunotherapy    applicable    methodology    dk    serve    therapies    outcomes    films    significantly    ef    ri    train    platform    overarching    year    complications    drug    illustrated    insights    leverage    anthracycline    postdoc    tools    biomedical    fellowship    group    chip    vitro    strain    models    rationale    leader    death    recapitulate    human    found    tissue   

Project "IN-3D-CAN" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 212˙194.00

Map

 Project objective

Rationale: Cardiotoxicity side effects are a recurrent problem for cancer therapies, fatally illustrated by the death of numerous patients treated with anthracycline chemotherapeutics. More recently, cardiac complications have also been found for antibody-based and immunotherapy treatments. Microphysiological systems and organs-on-chips may provide part of the long-term solution to these issues, by introducing improved means for studying human tissue in vitro. Main objective: The overarching objective of IN-3D-CAN is to establish instrumented in vitro 3D models of human cardiac muscle for high-throughput cardiotoxicity screening of cancer drugs and therapies. Methodology: In a recent first-author paper in Nature Materials, we reported the first entirely 3D-printed organ-on-chip with integrated sensors: A heart-on-a-chip with strain sensors for tracking engineered 2D cardiac thin films. In this proposal, I significantly expand on this 3D printing methodology, focusing on thicker 3D tissue models that better recapitulate native cardiac muscle. I will leverage the insights of the supervisor to perform toxicity screening of a range of cancer therapies. Outcomes: The proposal will establish unique tools for long-term and high-throughput studies of drug toxicity on human cardiac muscle in vitro. It will further provide unique insights into the cardiotoxicity of several cancer therapies on human cardiac muscle. Finally, the techniques for 3D printing will be widely applicable for biomedical micro-devices. Career: I am applying for an MSCA-IF-EF-RI, to reintegrate to DTU(DK), after more than 4 years abroad as Postdoc at Harvard Uni. (US) The fellowship will serve as year 1 and 2 of a 4-year assistant professorship. The host DTU Nanotech has committed to provide funding for year 3 and 4. The key career development objective is therefore to train me to become an independent group leader. Thus, In-3D-CAN will serve as immediate and long-term platform for my research.

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The information about "IN-3D-CAN" are provided by the European Opendata Portal: CORDIS opendata.

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