EU H2020 Project "IN-3D-CAN (Instrumented 3D-Printed Miniature Muscles for Cardiotoxicity Screens of..)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/215672/index.html

IN-3D-CAN project word cloud

Explore the words cloud of the IN-3D-CAN project. It provides you a very rough idea of what is the project "IN-3D-CAN" about.

introducing recapitulate uni outcomes platform recurrent therapies first ri dk human group sensors 2d models fellowship train vitro ef micro printing organ complications thin independent anthracycline immunotherapy paper chemotherapeutics muscle patients msca am expand perform native instrumented engineered tools year career techniques death insights committed antibody entirely organs drug host chip screening fatally significantly professorship me assistant heart tracking harvard tissue dtu microphysiological thicker methodology serve found postdoc films cardiac drugs overarching author illustrated cardiotoxicity solution chips strain cancer 3d toxicity applicable biomedical leader reported rationale printed nanotech treatments throughput leverage supervisor nature abroad materials reintegrate

Project "IN-3D-CAN" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	212˙194 €
EC max contribution	212˙194 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2020-06-30

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET	DK (KGS LYNGBY)	coordinator	212˙194.00

DANMARKS TEKNISKE UNIVERSITET

DK (KGS LYNGBY)

coordinator

212˙194.00

Project objective

Rationale: Cardiotoxicity side effects are a recurrent problem for cancer therapies, fatally illustrated by the death of numerous patients treated with anthracycline chemotherapeutics. More recently, cardiac complications have also been found for antibody-based and immunotherapy treatments. Microphysiological systems and organs-on-chips may provide part of the long-term solution to these issues, by introducing improved means for studying human tissue in vitro. Main objective: The overarching objective of IN-3D-CAN is to establish instrumented in vitro 3D models of human cardiac muscle for high-throughput cardiotoxicity screening of cancer drugs and therapies. Methodology: In a recent first-author paper in Nature Materials, we reported the first entirely 3D-printed organ-on-chip with integrated sensors: A heart-on-a-chip with strain sensors for tracking engineered 2D cardiac thin films. In this proposal, I significantly expand on this 3D printing methodology, focusing on thicker 3D tissue models that better recapitulate native cardiac muscle. I will leverage the insights of the supervisor to perform toxicity screening of a range of cancer therapies. Outcomes: The proposal will establish unique tools for long-term and high-throughput studies of drug toxicity on human cardiac muscle in vitro. It will further provide unique insights into the cardiotoxicity of several cancer therapies on human cardiac muscle. Finally, the techniques for 3D printing will be widely applicable for biomedical micro-devices. Career: I am applying for an MSCA-IF-EF-RI, to reintegrate to DTU(DK), after more than 4 years abroad as Postdoc at Harvard Uni. (US) The fellowship will serve as year 1 and 2 of a 4-year assistant professorship. The host DTU Nanotech has committed to provide funding for year 3 and 4. The key career development objective is therefore to train me to become an independent group leader. Thus, In-3D-CAN will serve as immediate and long-term platform for my research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IN-3D-CAN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IN-3D-CAN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)