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IN-3D-CAN SIGNED

Instrumented 3D-Printed Miniature Muscles for Cardiotoxicity Screens of Cancer Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

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 IN-3D-CAN project word cloud

Explore the words cloud of the IN-3D-CAN project. It provides you a very rough idea of what is the project "IN-3D-CAN" about.

chips    tissue    engineered    micro    assistant    platform    death    anthracycline    therapies    cardiotoxicity    tools    ri    toxicity    muscle    treatments    chemotherapeutics    models    ef    msca    expand    strain    leader    outcomes    dtu    me    fatally    found    recurrent    overarching    abroad    author    materials    throughput    drugs    committed    cancer    harvard    insights    2d    career    supervisor    tracking    year    illustrated    biomedical    printing    heart    immunotherapy    fellowship    sensors    reported    nanotech    cardiac    reintegrate    uni    first    antibody    entirely    group    drug    introducing    organ    dk    am    instrumented    professorship    rationale    microphysiological    native    vitro    human    serve    printed    nature    organs    techniques    train    leverage    films    solution    postdoc    methodology    perform    applicable    complications    significantly    recapitulate    thin    patients    thicker    host    chip    screening    3d    independent    paper   

Project "IN-3D-CAN" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 212˙194.00

Map

 Project objective

Rationale: Cardiotoxicity side effects are a recurrent problem for cancer therapies, fatally illustrated by the death of numerous patients treated with anthracycline chemotherapeutics. More recently, cardiac complications have also been found for antibody-based and immunotherapy treatments. Microphysiological systems and organs-on-chips may provide part of the long-term solution to these issues, by introducing improved means for studying human tissue in vitro. Main objective: The overarching objective of IN-3D-CAN is to establish instrumented in vitro 3D models of human cardiac muscle for high-throughput cardiotoxicity screening of cancer drugs and therapies. Methodology: In a recent first-author paper in Nature Materials, we reported the first entirely 3D-printed organ-on-chip with integrated sensors: A heart-on-a-chip with strain sensors for tracking engineered 2D cardiac thin films. In this proposal, I significantly expand on this 3D printing methodology, focusing on thicker 3D tissue models that better recapitulate native cardiac muscle. I will leverage the insights of the supervisor to perform toxicity screening of a range of cancer therapies. Outcomes: The proposal will establish unique tools for long-term and high-throughput studies of drug toxicity on human cardiac muscle in vitro. It will further provide unique insights into the cardiotoxicity of several cancer therapies on human cardiac muscle. Finally, the techniques for 3D printing will be widely applicable for biomedical micro-devices. Career: I am applying for an MSCA-IF-EF-RI, to reintegrate to DTU(DK), after more than 4 years abroad as Postdoc at Harvard Uni. (US) The fellowship will serve as year 1 and 2 of a 4-year assistant professorship. The host DTU Nanotech has committed to provide funding for year 3 and 4. The key career development objective is therefore to train me to become an independent group leader. Thus, In-3D-CAN will serve as immediate and long-term platform for my research.

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The information about "IN-3D-CAN" are provided by the European Opendata Portal: CORDIS opendata.

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