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IN-3D-CAN SIGNED

Instrumented 3D-Printed Miniature Muscles for Cardiotoxicity Screens of Cancer Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

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 IN-3D-CAN project word cloud

Explore the words cloud of the IN-3D-CAN project. It provides you a very rough idea of what is the project "IN-3D-CAN" about.

introducing    recapitulate    uni    outcomes    platform    recurrent    therapies    first    ri    dk    human    group    sensors    2d    models    fellowship    train    vitro    ef    micro    printing    organ    complications    thin    independent    anthracycline    immunotherapy    paper    chemotherapeutics    muscle    patients    msca    am    expand    perform    native    instrumented    engineered    tools    year    career    techniques    death    insights    committed    antibody    entirely    organs    drug    host    chip    screening    fatally    significantly    professorship    me    assistant    heart    tracking    harvard    tissue    dtu    microphysiological    thicker    methodology    serve    found    postdoc    films    cardiac    drugs    overarching    author    illustrated    cardiotoxicity    solution    chips    strain    cancer    3d    toxicity    applicable    biomedical    leader    reported    rationale    printed    nanotech    treatments    throughput    leverage    supervisor    nature    abroad    materials    reintegrate   

Project "IN-3D-CAN" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 212˙194.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Rationale: Cardiotoxicity side effects are a recurrent problem for cancer therapies, fatally illustrated by the death of numerous patients treated with anthracycline chemotherapeutics. More recently, cardiac complications have also been found for antibody-based and immunotherapy treatments. Microphysiological systems and organs-on-chips may provide part of the long-term solution to these issues, by introducing improved means for studying human tissue in vitro. Main objective: The overarching objective of IN-3D-CAN is to establish instrumented in vitro 3D models of human cardiac muscle for high-throughput cardiotoxicity screening of cancer drugs and therapies. Methodology: In a recent first-author paper in Nature Materials, we reported the first entirely 3D-printed organ-on-chip with integrated sensors: A heart-on-a-chip with strain sensors for tracking engineered 2D cardiac thin films. In this proposal, I significantly expand on this 3D printing methodology, focusing on thicker 3D tissue models that better recapitulate native cardiac muscle. I will leverage the insights of the supervisor to perform toxicity screening of a range of cancer therapies. Outcomes: The proposal will establish unique tools for long-term and high-throughput studies of drug toxicity on human cardiac muscle in vitro. It will further provide unique insights into the cardiotoxicity of several cancer therapies on human cardiac muscle. Finally, the techniques for 3D printing will be widely applicable for biomedical micro-devices. Career: I am applying for an MSCA-IF-EF-RI, to reintegrate to DTU(DK), after more than 4 years abroad as Postdoc at Harvard Uni. (US) The fellowship will serve as year 1 and 2 of a 4-year assistant professorship. The host DTU Nanotech has committed to provide funding for year 3 and 4. The key career development objective is therefore to train me to become an independent group leader. Thus, In-3D-CAN will serve as immediate and long-term platform for my research.

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The information about "IN-3D-CAN" are provided by the European Opendata Portal: CORDIS opendata.

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