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NanoGlia SIGNED

Understanding the impact of nanoplastics on the development of neurological disorders

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 NanoGlia project word cloud

Explore the words cloud of the NanoGlia project. It provides you a very rough idea of what is the project "NanoGlia" about.

pathogenesis    nanoglia    speculated    functions    internalize    understudied    spread    web    leads    fish    ground    turn    food    health    influence    insights    defence    molecular    risk    pollution    plastics    bioavailability    breaking    translocate    mechanistic    discovered    unknown    cellular    events    homeostasis    ingestion    constantly    developmental    normal    human    triggers    triggered    line    abnormal    microglial    gut    rodent    phagocytic    neurodegeneration    postnatal    environmentally    neuronal    shown    cells    an    humans    omnipresent    sized    immune    behavioural    embryogenesis    models    barrier    lymph    thereby    causes    fetal    interface    housekeeping    nanoplastics    environmental    brain    microglia    capacity    circulatory    detected    animal    reveal    organogenesis    places    chronic    reprogramming    permanent    stages    neurological    acute    neuroimmune    mammals    particles    blood    reaching    activation    nano    variety    function    toxicity    ecosystems    sense    enter    plastic    cross    inflammatory    disorders    ingested   

Project "NanoGlia" data sheet

The following table provides information about the project.

Coordinator
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN 

Organization address
address: REGINA PACIS WEG 3
city: BONN
postcode: 53113
website: www.uni-bonn.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙193 €
 EC max contribution 1˙497˙193 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN DE (BONN) coordinator 1˙497˙193.00

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 Project objective

An omnipresent but understudied environmental risk for our immune system is pollution by nano-sized plastics. Plastic particles have been detected in a wide variety of ecosystems and are speculated to enter and spread in the food web all the way to humans. Ingested nanoplastics can translocate from the gut to the lymph and circulatory systems and have the capacity to cross the blood-brain barrier in mammals. It has been recently shown that nanoplastics cause behavioural disorders in fish, and thus may also represent a risk for human health, in particular for brain function. However, the long-term bioavailability and toxicity of nanoplastics in the brain are unknown. Microglia as the main neuroimmune cells have not only a defence function required during inflammatory conditions, but constantly sense and response to environmental changes as part of their housekeeping functions that are essential for neuronal homeostasis. This places microglia at the interface between normal and abnormal brain development and function. In line with this, we have recently discovered that chronic microglial activation causes neurodegeneration. As highly phagocytic cells, microglia internalize nanoplastics reaching the brain. This process might in turn lead to their acute or chronic activation, thereby triggering neurological disorders. In NanoGlia, we will use rodent animal models to investigate behavioural as well as cellular and molecular changes in the brain that occur upon ingestion of nanoplastics. We will further determine nanoplastics-induced developmental reprogramming events in fetal microglia that may influence brain organogenesis and function. Understanding how nanoplastics triggers microglial activation during embryogenesis and postnatal stages and whether this immune activation leads to permanent changes in brain development and function will reveal ground-breaking mechanistic insights into the environmentally triggered pathogenesis of neurological disorders.

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The information about "NANOGLIA" are provided by the European Opendata Portal: CORDIS opendata.

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