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REGENERA SIGNED

Helping cancer survivors restoring their natural breast with resorbable implants inducing self‐tissue regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 REGENERA project word cloud

Explore the words cloud of the REGENERA project. It provides you a very rough idea of what is the project "REGENERA" about.

adipocytes    polyurethaneester    241m    surgery    vivo    time    tissue    save    reconstructive    multiple    risks    micro    whom    prosthesis    cancer    leads    nowadays    implantation    tensive    integration    regenera    absorbable    women    alternative    carcinogenic    scaffold    linked    society    2025    35m    breast    silicone    levels    sustainability    surgeries    cumulative    vascular    interventions    vascularization    needing    quality    reconstructions    synthetic    patient    roi    undergoing    230    biocompatible    bio    market    innovative    perpetuate    lumpectomy    permanent    good    grafting    personal    meet    patients    acute    benefit    network    replacement    implants    helping    maintaining    solution    scaffolds    founded    profit    mastectomy    medicine    regenerative    single    colonization    healthcare    modifications    augmentation    replaced    19    2012    37    surgical    reasons    15    biomaterials    volume    yearly    additional    mammary    intervention    patented    solutions    revenues    257m    blood    reconstructed    necrosis    degraded    company    life    fat    vessels   

Project "REGENERA" data sheet

The following table provides information about the project.

Coordinator
TENSIVE SRL 

Organization address
address: VIA TIMAVO 34
city: MILANO
postcode: 20124
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.regenerabreast.com/
 Total cost 2˙698˙813 €
 EC max contribution 1˙889˙169 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TENSIVE SRL IT (MILANO) coordinator 1˙889˙169.00

Map

 Project objective

Tensive was founded in 2012 to address the challenge of developing better biomaterials for regenerative medicine. We developed a bio absorbable scaffold based on highly biocompatible polyurethaneester. Our patented scaffolds provide a synthetic micro-vascular network that enables adipocytes colonization in vivo. This unique design leads to vascularization, fat integration and volume maintaining after implantation. Based on these unique properties, we will bring to the market REGENERA, an innovative mammary prosthesis that is degraded over time and replaced by the patient´s fat. Silicone implants, the most currently used breast tissue modifications, have important risks and need replacement every 10-15 years. Fat grafting, the best alternative nowadays, has been linked to carcinogenic risks and does not promote vascularization (leading to necrosis) with multiple interventions needed for large reconstructions. REGENERA, which only requires one surgical intervention, will meet the need to develop biomaterials able to promote new blood vessels formation that perpetuate the reconstructed tissue. REGENERA will have a significant impact on various levels: (i) Healthcare system: it will save the cost of additional surgeries (more than €241M yearly in the EU), helping to the sustainability of the Healthcare system. (ii) breast cancer patients: it will offer a solution to lumpectomy patients, for whom there are no good solutions yet; a better alternative for mastectomy and breast augmentation patients; a permanent solution by a single surgery for all patients, improving their quality of life. (iii) company: it will increase Tensive’s revenues (cumulative profit of €257M with a ROI of 19.37 by 2025) (iv) society: it will highly benefit 230,000 women needing reconstructive surgery after breast cancer, together with the 1.35M women undergoing breast augmentation for personal reasons

 Deliverables

List of deliverables.
Web page of the project Documents, reports 2019-10-01 09:19:20

Take a look to the deliverables list in detail:  detailed list of REGENERA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Eleonora Rossi, Julien Guerrero, Paola Aprile, Alessandro Tocchio, Elisabeth A. Kappos, Irini Gerges, Cristina Lenardi, Ivan Martin, Arnaud Scherberich
Decoration of RGD-mimetic porous scaffolds with engineered and devitalized extracellular matrix for adipose tissue regeneration
published pages: 154-166, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.04.039
Acta Biomaterialia 73 2019-08-30
2018 Irini Gerges, Margherita Tamplenizza, Federico Martello, Camilla Recordati, Cristina Martelli, Luisa Ottobrini, Mariacaterina Tamplenizza, Scott A. Guelcher, Alessandro Tocchio, Cristina Lenardi
Exploring the potential of polyurethane-based soft foam as cell-free scaffold for soft tissue regeneration
published pages: 141-153, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.04.011
Acta Biomaterialia 73 2019-08-30

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The information about "REGENERA" are provided by the European Opendata Portal: CORDIS opendata.

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