Opendata, web and dolomites

NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

2030    competencies    placed    fergal    feedback    loaded    public    contributions    cartilage    ireland    msca    mechanobiology    repair    leader    network    detected    expertise    bioengineering    fellow    prof    post    osteoarthritis    traumatic    materials    tissue    marrow    financials    agents    alginate    anterior    trinity    gdp    amber    leads    microdamage    expand    region    competitiveness    double    cruciate    royal    collaborators    socio    knee    he    breakthroughs    hope    world    combine    damage    economic    brien    following    equivalent    million    delivered    center    experts    disciplinary    reporting    supervisor    college    subchondral    leadership    leave    bisphosphonate    abroad    patents    direct    pi    group    commercialization    rarely    oa    tcbe    dramatic    occurs    mri    prevent    acl    joint    relationship    nine    terg    sub    biomaterials    injectable    therapy    costing    rcsi    people    surgeons    lesions    transferable    ptoa    bone    injury    uncertain    skills    remodeling    rupture    leaders    80    microparticles    engineering    12    linked    skeletal    impacts    bmls    senior    ligament       drug    me    international    training    acute    disorder   

Project "NovelKnees" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOVELKNEES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CAR-OAC (2020)

Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings

Read More  

GAiNS (2020)

Gibberellic acid signaling and dynamics during arbuscular mycorrhizal symbiosis and rhizobial-legume symbiosis

Read More  

HSQG (2020)

Higher Spin Quantum Gravity: Lagrangian Formulations for Higher Spin Gravity and Their Applications

Read More