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NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €

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EC-Contrib. €

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Partnership

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 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

knee    commercialization    subchondral    expand    leads    leader    group    acl    world    contributions    prevent    college    breakthroughs    socio    ptoa    fellow    pi    transferable    biomaterials    placed    dramatic    leave    fergal    relationship    80    collaborators    disciplinary    brien    skills    million    impacts    ireland    public    msca    international    injectable    following    trinity    me    therapy    he    oa    12    engineering    traumatic    patents    cartilage    double    post    center    experts    delivered    surgeons    reporting    mri    rcsi    nine    tcbe    leaders    prof    direct    sub    bisphosphonate    detected    joint    training    alginate    damage    gdp    lesions       economic    osteoarthritis    repair    competitiveness    bmls    region    leadership    agents    cruciate    rarely    feedback    linked    expertise    ligament    loaded    skeletal    network    occurs    equivalent    acute    microparticles    bioengineering    mechanobiology    anterior    costing    marrow    materials    combine    amber    2030    people    tissue    abroad    royal    terg    injury    uncertain    financials    senior    hope    remodeling    disorder    rupture    drug    microdamage    competencies    supervisor    bone   

Project "NovelKnees" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

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The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

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