Opendata, web and dolomites

NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €


EC-Contrib. €






 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

bisphosphonate    commercialization    leadership    linked    materials    prevent    mri    equivalent    trinity    cartilage    12    surgeons    region    agents    ptoa    fergal    rarely    bmls    contributions    therapy    royal    hope    leader    terg    drug    dramatic    osteoarthritis    amber    people    rcsi    leads    bioengineering    expertise    public    expand    alginate    socio    marrow    acute    impacts    transferable    cruciate    repair       subchondral    delivered    world    abroad    leaders    disciplinary    college    placed    senior    reporting    gdp    microdamage    2030    nine    skeletal    patents    million    breakthroughs    collaborators    microparticles    biomaterials    ireland    competitiveness    group    knee    combine    rupture    supervisor    acl    relationship    occurs    costing    remodeling    lesions    he    loaded    experts    uncertain    injury    sub    detected    engineering    tissue    tcbe    following    msca    training    me    prof    direct    fellow    post    joint    anterior    double    80    disorder    skills    competencies    oa    traumatic    network    bone    international    brien    ligament    leave    damage    mechanobiology    economic    pi    injectable    financials    center    feedback   

Project "NovelKnees" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOVELKNEES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More