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NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €

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EC-Contrib. €

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Partnership

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 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

disciplinary    leave    expertise    contributions    linked    bioengineering    competencies    transferable    leaders    center    1    cartilage    engineering    experts    anterior    economic    prevent    subchondral    acl    biomaterials    remodeling    microparticles    leads    terg    leader    lesions    80    drug    bmls    senior    injury    traumatic    damage    tissue    rarely    bone    disorder    alginate    impacts    occurs    ireland    million    surgeons    collaborators    commercialization    injectable    skeletal    placed    mechanobiology    marrow    tcbe    equivalent    patents    financials    msca    network    competitiveness    loaded    leadership    ptoa    college    acute    expand    cruciate    12    2030    public    combine    relationship    pi    me    joint    agents    knee    mri    materials    uncertain    region    brien    double    fergal    international    therapy    nine    rupture    delivered    oa    ligament    socio    post    people    training    trinity    amber    he    detected    group    prof    costing    world    dramatic    gdp    microdamage    skills    bisphosphonate    following    rcsi    reporting    repair    direct    fellow    supervisor    osteoarthritis    breakthroughs    sub    royal    feedback    abroad    hope   

Project "NovelKnees" data sheet

The following table provides information about the project.

Coordinator		 ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

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The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

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