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NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €

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EC-Contrib. €

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Partnership

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 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

1    cruciate    post    cartilage    injectable    bisphosphonate    experts    leader    pi    bone    supervisor    tcbe    ligament    skills    msca    occurs    tissue    engineering    dramatic    loaded    public    brien    hope    anterior    materials    remodeling    patents    leaders    joint    biomaterials    collaborators    injury    following    damage    leave    acl    osteoarthritis    2030    college    microparticles    leadership    commercialization    ptoa    gdp    disciplinary    group    people    disorder    rarely    fergal    transferable    therapy    contributions    delivered    he    relationship    traumatic    training    international    senior    combine    direct    drug    alginate    amber    double    me    marrow    subchondral    ireland    12    equivalent    financials    sub    acute    skeletal    economic    million    detected    mri    impacts    reporting    80    lesions    socio    nine    competencies    center    network    repair    uncertain    bmls    bioengineering    prevent    costing    terg    leads    rcsi    expand    trinity    microdamage    region    oa    prof    linked    surgeons    competitiveness    feedback    expertise    fellow    rupture    knee    placed    mechanobiology    breakthroughs    royal    agents    world    abroad   

Project "NovelKnees" data sheet

The following table provides information about the project.

Coordinator		 ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

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The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

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