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NovelKnees SIGNED

Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury

Total Cost €


EC-Contrib. €






 NovelKnees project word cloud

Explore the words cloud of the NovelKnees project. It provides you a very rough idea of what is the project "NovelKnees" about.

leaders    traumatic    following    costing    remodeling    cartilage    tissue    alginate    ireland    double    ptoa    materials    injectable    training    bioengineering    contributions    international    knee    microparticles    hope    competitiveness    biomaterials    subchondral    world    center    me    leads    microdamage    placed    mechanobiology    damage    acute    cruciate    engineering    disciplinary    gdp    prof    pi    terg    financials    tcbe    joint    disorder    occurs    expertise    rarely    expand    competencies    network    patents    leave    loaded    feedback    relationship    leader    college    detected    mri    brien    bmls    lesions    acl    rcsi    surgeons    breakthroughs    million    transferable    reporting    socio    people    nine    dramatic    senior    experts    economic    msca    he    skills    supervisor    12    sub    bisphosphonate       public    bone    anterior    collaborators    rupture    combine    abroad    uncertain    royal    oa    repair    equivalent    prevent    post    therapy    leadership    drug    fellow    delivered    fergal    skeletal    osteoarthritis    group    ligament    marrow    region    2030    direct    commercialization    linked    trinity    agents    impacts    80    injury    amber   

Project "NovelKnees" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dissemination/public awareness, patents and commercialization. All of these will combine to leave me well-placed to provide meaningful contributions to Europe’s competitiveness and growth in the future.

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The information about "NOVELKNEES" are provided by the European Opendata Portal: CORDIS opendata.

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