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FUCTURE SIGNED

Fucosylated Clusterin: a novel mechanism of tumor escape from immune response

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUCTURE project word cloud

Explore the words cloud of the FUCTURE project. It provides you a very rough idea of what is the project "FUCTURE" about.

overexpressed    antigens    models    hypothesize    dr    cell    modulation    effect    bears    tumor    association    nature    expertise    advantage    showed    published    vivo    antigen    preventing    promotes    receptor    mice    presentation    immune    lectin    excellence    tolerogenic    prognosis    communicated    seminal    glycans    chaperone    breast    confers    dc    mac    amigorena    ubiquitous    scientific    bind    cancer    model    anti    fucosylated    function    community    pattern    mechanism    expressed    adoptive    aggregates    society    apoptotic    glycoprotein    meetings    base    tumors    clu    context    sense    discovered    curie    whenever    endocytic    plasma    proteins    dendritic    immunosuppression    expression    obscure    cancers    cells    stromal    independent    clusterin    binding    extracellular    journals    regression    insoluble    generation    fuc    preliminary    competitive    dcs    spontaneous    sign    escape    bad    macrophages    previously    transfer    immunity    peer    isoform    position    expressing    stressed   

Project "FUCTURE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-15   to  2020-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Clusterin (CLU) is a ubiquitous glycoprotein that function as an extracellular chaperone, binding to apoptotic cells and stressed-proteins and preventing the generation of insoluble aggregates. Although CLU is overexpressed in many type of cancers and associated with bad prognosis, the nature of this association remains obscure. It has been previously discovered an isoform of CLU present in seminal plasma that bears fucosylated glycans that confers the ability to bind to DC-SIGN; an endocytic C-type lectin receptor expressed on dendritic cells (DCs) and macrophages (MAC) that has been associated with immunosuppression. Our preliminary results showed spontaneous regression of tumors in CLU-/- mice after adoptive transfer in 2 models. We also observed that CLU present in breast cancer bears fucosylated glycans with the ability to bind to DC-SIGN. We hypothesize that tumor fucosylated CLU (Fuc-CLU) promotes immunosuppression by targeting tumor cell-associated antigens to DC-SIGN expressing DCs and MAC, promoting antigen presentation in a tolerogenic context. In this sense, Fuc-CLU could represent a new mechanism of tumor escape from immune response. The main objectives are: to analyse Fuc-CLU expression pattern and production by tumor and stromal cells; to address the role of Fuc-CLU in immune modulation and tumor cell-associated antigen presentation; and to study the effect of Fuc-CLU on tumor development in an in-vivo model. The expertise of Dr. Amigorena and Institute Curie represent a major competitive advantage for the project. The results are expected to be published in peer-reviewed journals of high impact (with Open Access whenever possible), communicated in scientific meetings and to society at large. Expected results and deliverables will enhance the knowledge base and excellence of the European Scientific Community in the field anti-tumor immunity. This experience will be a key step for my scientific development to reach an independent position.

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The information about "FUCTURE" are provided by the European Opendata Portal: CORDIS opendata.

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