Opendata, web and dolomites

FUCTURE SIGNED

Fucosylated Clusterin: a novel mechanism of tumor escape from immune response

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FUCTURE project word cloud

Explore the words cloud of the FUCTURE project. It provides you a very rough idea of what is the project "FUCTURE" about.

regression    confers    amigorena    curie    aggregates    preliminary    tumor    antigens    hypothesize    seminal    sense    plasma    association    immunosuppression    transfer    community    immune    proteins    fuc    mac    journals    fucosylated    cancers    escape    mechanism    expressing    glycans    expression    clusterin    anti    bears    isoform    vivo    prognosis    bind    expressed    glycoprotein    overexpressed    promotes    published    effect    spontaneous    base    stromal    insoluble    apoptotic    models    context    cancer    position    extracellular    model    function    expertise    binding    competitive    cell    lectin    tolerogenic    tumors    peer    excellence    discovered    immunity    modulation    sign    advantage    nature    meetings    showed    chaperone    society    clu    generation    receptor    independent    previously    cells    dcs    whenever    presentation    endocytic    pattern    ubiquitous    stressed    dendritic    adoptive    scientific    dc    obscure    bad    mice    breast    antigen    dr    communicated    macrophages    preventing   

Project "FUCTURE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-15   to  2020-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Clusterin (CLU) is a ubiquitous glycoprotein that function as an extracellular chaperone, binding to apoptotic cells and stressed-proteins and preventing the generation of insoluble aggregates. Although CLU is overexpressed in many type of cancers and associated with bad prognosis, the nature of this association remains obscure. It has been previously discovered an isoform of CLU present in seminal plasma that bears fucosylated glycans that confers the ability to bind to DC-SIGN; an endocytic C-type lectin receptor expressed on dendritic cells (DCs) and macrophages (MAC) that has been associated with immunosuppression. Our preliminary results showed spontaneous regression of tumors in CLU-/- mice after adoptive transfer in 2 models. We also observed that CLU present in breast cancer bears fucosylated glycans with the ability to bind to DC-SIGN. We hypothesize that tumor fucosylated CLU (Fuc-CLU) promotes immunosuppression by targeting tumor cell-associated antigens to DC-SIGN expressing DCs and MAC, promoting antigen presentation in a tolerogenic context. In this sense, Fuc-CLU could represent a new mechanism of tumor escape from immune response. The main objectives are: to analyse Fuc-CLU expression pattern and production by tumor and stromal cells; to address the role of Fuc-CLU in immune modulation and tumor cell-associated antigen presentation; and to study the effect of Fuc-CLU on tumor development in an in-vivo model. The expertise of Dr. Amigorena and Institute Curie represent a major competitive advantage for the project. The results are expected to be published in peer-reviewed journals of high impact (with Open Access whenever possible), communicated in scientific meetings and to society at large. Expected results and deliverables will enhance the knowledge base and excellence of the European Scientific Community in the field anti-tumor immunity. This experience will be a key step for my scientific development to reach an independent position.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FUCTURE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FUCTURE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More