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Role and regulation of dendritic cell functions by Solute Carrier Transporters

Total Cost €


EC-Contrib. €






 TakeupSLaCk project word cloud

Explore the words cloud of the TakeupSLaCk project. It provides you a very rough idea of what is the project "TakeupSLaCk" about.

machinery    autoimmunity    cells    wil    rare    ingested    group    fast    antigens    plethora    pathogens    helps    transcriptional    technologies    healthy    membrane    function    beginning    recruiting    immune    vivo    tolerogenic    family    immunogenic    relevance    efficient    regulation    adaptive    deal    slcs    human    receptors    pathogen    proteins    reflected    reveal    altered    engulfment    export    equipped    lipids    carrier    elimination    heterogeneous    sensing    cutting    infectious    functions    initation    fatty    comprise    linked    mouse    prrs    daily    turn    prevent    time    insights    lymphocytes    cargos    confronted    slc    therapeutics    import    adapt    sophisticated    metabolic    presenting    programs    dcs    vast    biology    models    expression    solute    diseases    phagocytes    edge    phagocytic    material    ions    transporters    mediate    altogether    recognition    first    dc    tissue    homeostasis    dendritic    genome    drugs    nutrients    acids    appreciate    drug    dreaded    apoptotic    dictate    dissect    bound    external    billions    dying    relatively   

Project "TakeupSLaCk" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00


 Project objective

Phagocytes are confronted daily with the dreaded task to respond to billions of dying cells and a plethora of external pathogens. Dendritic cells (DCs) comprise a heterogeneous group of phagocytes that are equipped with several phagocytic and pathogen recognition receptors (PRRs), and with the processing machinery to mediate efficient elimination of apoptotic or infectious cargos. This, in turn, helps to maintain tissue homeostasis and prevent autoimmunity. However, there is fast-growing evidence that DC functions also affect metabolic pathways. Moreover, we are now beginning to appreciate that phagocytes need to adapt to metabolic changes and deal with the ingested material by recruiting, among others, the membrane-bound solute carrier transporters (SLCs). SLCs are the second largest family of membrane proteins in the human genome, yet remain relatively under-studied. SLCs mediate the import and export of ions, nutrients, lipids, fatty acids or drugs, and the relevance of their functions is reflected by the vast number of diseases linked to altered expression or function of SLCs, and the many drugs that target SLCs. Using sophisticated mouse models, we will analyse the expression of SLCs in DC subsets in vivo upon engulfment of apoptotic or infectious cargos. Using cutting edge technologies, we will dissect the transcriptional and metabolic programs that dictate functions of DC subsets in both tolerogenic and immunogenic conditions. We wil address, for the first time, the role of SLCs in major DC functions such as sensing pathogens and presenting antigens to T lymphocytes for the initation of adaptive immune responses. Altogether, this study will provide new insights into SLC regulation and DC biology. This proposal has the potential not only to reveal novel aspects of the use of SLCs for drug development and therapeutics of both common and rare diseases, and to enhance the targeting of engulfment or of metabolic pathways in healthy states.

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