Explore the words cloud of the SympatimmunObesity project. It provides you a very rough idea of what is the project "SympatimmunObesity" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙029˙175 €|
|EC max contribution||2˙029˙175 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2019-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||2˙029˙175.00|
The era of molecular genetics has enabled the mechanistic dissection of brain circuits as well as the immune system in spectacular ways. However, the molecular and cellular organization of the sympathetic nervous system (SNS), which innervates all known organs, is essentially unexplored. In an attempt to push this frontier, we have recently uncovered a direct physical functional connection between the SNS and the adipose tissue. Further, we found this neuro-adipose junction to drive lipolysis and fat mass reduction (1). In this proposal we aim to define the molecular mechanisms that link SNS neurons, the immune system and the adipose tissue. A major entry point is our recent discovery of a novel population of Sympathetic Associated Macrophages (SAMs) that suppress the output of SNS. We propose to unravel their contribution to obesity in rodents (Aim 1) and in humans (Aim 2). Another major objective of this proposal is to establish a functional and molecular neuronanatomical map of the SNS, which defines subpopulations of neurons that specifically innervate fat (Aim 3). To achieve this, we will build molecular genetics tools for rapid non-invasive optocoustic visualization and functional probing of SNS circuits. A molecular and realistic atlas of the SNS will allow us to systematically access the functional anatomy of one of the most elusive tissues of the mammalian body and will form a blueprint upon which our neuroimmune mechanistic studies can be build. Our identification of the fundamental biological mechanisms that govern the neuro-adipose junction will set the stage for a new anti-obesity therapy that would circumvent the challenge of drug delivery to the brain, i.e. by targeting an excitatory drug directly to SAMs or sympathetic inputs in adipose tissue.
|year||authors and title||journal||last update|
Patricia Seoane-Collazo, Laura LiÃ±ares-Pose, Eva Rial-Pensado, Amparo Romero-PicÃ³, JosÃ© MarÃa Moreno-Navarrete, Noelia MartÃnez-SÃ¡nchez, Pablo Garrido-Gil, RamÃ³n Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, TomÃ¡s Sobrino, JosÃ© L. Labandeira-GarcÃa, RubÃ©n Nogueiras, Ana I. Domingos, JosÃ©-Manuel FernÃ¡ndez-Real, Kam
Central nicotine induces browning through hypothalamic Îº opioid receptor
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12004-z
|Nature Communications 10/1||2020-01-29|
Chelsea M. Larabee, Oliver C. Neely, Ana I. Domingos
Obesity: a neuroimmunometabolic perspective
published pages: 30-43, ISSN: 1759-5029, DOI: 10.1038/s41574-019-0283-6
|Nature Reviews Endocrinology 16/1||2020-01-29|
Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumar Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
Mediation of the Acute Stress Response by the Skeleton
published pages: 890-902.e8, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.08.012
|Cell Metabolism 30/5||2020-01-29|
Ana I. Domingos
Leptin: a missing piece in the immunometabolism puzzle
published pages: , ISSN: 1474-1733, DOI: 10.1038/s41577-019-0251-3
|Nature Reviews Immunology||2020-01-29|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYMPATIMMUNOBESITY" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SYMPATIMMUNOBESITY" are provided by the European Opendata Portal: CORDIS opendata.