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SympatimmunObesity SIGNED

Sympathetic and immune mechanisms underlying obesity

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EC-Contrib. €

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Project "SympatimmunObesity" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙029˙175 €
 EC max contribution 2˙029˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙029˙175.00

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 Project objective

The era of molecular genetics has enabled the mechanistic dissection of brain circuits as well as the immune system in spectacular ways. However, the molecular and cellular organization of the sympathetic nervous system (SNS), which innervates all known organs, is essentially unexplored. In an attempt to push this frontier, we have recently uncovered a direct physical functional connection between the SNS and the adipose tissue. Further, we found this neuro-adipose junction to drive lipolysis and fat mass reduction (1). In this proposal we aim to define the molecular mechanisms that link SNS neurons, the immune system and the adipose tissue. A major entry point is our recent discovery of a novel population of Sympathetic Associated Macrophages (SAMs) that suppress the output of SNS. We propose to unravel their contribution to obesity in rodents (Aim 1) and in humans (Aim 2). Another major objective of this proposal is to establish a functional and molecular neuronanatomical map of the SNS, which defines subpopulations of neurons that specifically innervate fat (Aim 3). To achieve this, we will build molecular genetics tools for rapid non-invasive optocoustic visualization and functional probing of SNS circuits. A molecular and realistic atlas of the SNS will allow us to systematically access the functional anatomy of one of the most elusive tissues of the mammalian body and will form a blueprint upon which our neuroimmune mechanistic studies can be build. Our identification of the fundamental biological mechanisms that govern the neuro-adipose junction will set the stage for a new anti-obesity therapy that would circumvent the challenge of drug delivery to the brain, i.e. by targeting an excitatory drug directly to SAMs or sympathetic inputs in adipose tissue.

 Publications

year authors and title journal last update
List of publications.
2019 Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kam
Central nicotine induces browning through hypothalamic κ opioid receptor
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12004-z
Nature Communications 10/1 2020-01-29
2020 Chelsea M. Larabee, Oliver C. Neely, Ana I. Domingos
Obesity: a neuroimmunometabolic perspective
published pages: 30-43, ISSN: 1759-5029, DOI: 10.1038/s41574-019-0283-6
Nature Reviews Endocrinology 16/1 2020-01-29
2019 Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumar Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
Mediation of the Acute Stress Response by the Skeleton
published pages: 890-902.e8, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.08.012
Cell Metabolism 30/5 2020-01-29
2019 Ana I. Domingos
Leptin: a missing piece in the immunometabolism puzzle
published pages: , ISSN: 1474-1733, DOI: 10.1038/s41577-019-0251-3
Nature Reviews Immunology 2020-01-29

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