Explore the words cloud of the MECHEMGUI project. It provides you a very rough idea of what is the project "MECHEMGUI" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙468˙520 €|
|EC max contribution||2˙468˙520 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-06-01 to 2023-05-31|
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|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||2˙468˙520.00|
During the development of the central nervous system (CNS), neurons extend axons through a crowded environment along well-defined pathways to reach their distant targets. It isA start date of 1st June 2018 is being requested to enable the PI to complete a number of current commitments and put the necessary arrangements in place to enable an efficient start up phase of the project. evident that attractive and repulsive guidance cues in the tissue provide important biochemical signals to guide growing axons along their paths. This can only be part of the story, however, as it is still not possible to predict axonal growth patterns in vivo. In a recent breakthrough discovery, we provided in vivo evidence that neurons also respond to mechanical cues, such as local tissue stiffness, suggesting that mechanical signals are likely an important missing part of the puzzle. However, mechanically activated signaling pathways are currently poorly understood, and how neurons integrate mechanical and chemical signals to result in proper outgrowth is unknown.
By investigating how mechanical signals control neuronal growth and pathfinding, this proposal will close this comprehension gap. By combining state-of-the-art approaches in physics, engineering and biology, we will, for the first time, identify mechanosensitive molecular mechanisms that regulate neuronal growth and guidance in vitro and in vivo. In particular, we will investigate how mechanotransduction cascades (1) directly modulate axon growth by inducing local changes in cytoskeletal dynamics, and (2) indirectly lead to alterations in axon outgrowth by modulating chemical signalling pathways. Ultimately, we will develop a computational model based on our findings, which will lead to a predictive framework for understanding axon pathfinding in the developing brain.
The proposed research challenges current concepts in developmental biology and is very relevant to many other areas in biology. Our results will not only shed new light on the complex control mechanisms of cellular growth and motility, but could also lead to novel biomedical approaches aimed at facilitating neuronal re-growth and regeneration in the damaged CNS.
|year||authors and title||journal||last update|
Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J Brosens, Ashley Moffett, Andrew M Sharkey, Kristian Franze, Graham J Burton, Michelle L Oyen
Tissue stiffness at the human maternalâ€“fetal interface
published pages: 1999-2008, ISSN: 0268-1161, DOI: 10.1093/humrep/dez139
|Human Reproduction 34/10||2020-02-05|
Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
KymoButler, a deep learning software for automated kymograph analysis
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.42288
Michael Segel, BjÃ¶rn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Niche stiffness underlies the ageing of central nervous system progenitor cells
published pages: 130-134, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1484-9
Amelia J Thompson, Eva K Pillai, Ivan B Dimov, Sarah K Foster, Christine E Holt, Kristian Franze
Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.39356
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