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Hypo-RESOLVE SIGNED

Hypoglycaemia - REdefining SOLutions for better liVEs

Total Cost €

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EC-Contrib. €

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Partnership

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 Hypo-RESOLVE project word cloud

Explore the words cloud of the Hypo-RESOLVE project. It provides you a very rough idea of what is the project "Hypo-RESOLVE" about.

kin    diabetes    clinic    decline    epidemiologic    below    trials    10    clinical    stakeholders    decreases    diabetic    events    line    mechanisms    science    input    life    glucose    diseases    psychological    burden    global    lives    risk    detected    cognitive    event    elevated    significance    principal    health    complications    valuable    altogether    resolve    restoration    patient    levels    secure    quantify    barrier    150    impaired    creates    alleviate    improves    symptoms    prevents    statistical    saves    chronic    power    public    society    cgm    underlying    serious    outcomes    economic    construct    microvascular    huge    million    hypo    basic    mortality    prevalent    normalising    explore    hypoglycaemia    patients    impacts    quality    treatment    answering    communicable    reduce    constitutes    partnership    people    threshold    prevent    translational    whom    insulin    cardiovascular    questions    populations    classification    hyperglycaemia    private    poor    regulators    databases    individual    sustainable    data   

Project "Hypo-RESOLVE" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://hypo-resolve.eu/
 Total cost 26˙774˙582 €
 EC max contribution 13˙450˙057 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2016-10-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙301˙983.00
2    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 1˙990˙508.00
3    SYDDANSK UNIVERSITET DK (ODENSE M) participant 1˙354˙981.00
4    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 1˙351˙453.00
5    REGION HOVEDSTADEN DK (HILLEROD) participant 1˙030˙750.00
6    UNIVERSITE DE LAUSANNE CH (LAUSANNE) participant 955˙601.00
7    SIB INSTITUT SUISSE DE BIOINFORMATIQUE CH (GENEVE) participant 934˙250.00
8    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) participant 800˙000.00
9    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 661˙202.00
10    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 502˙125.00
11    CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER FR (MONTPELLIER) participant 465˙000.00
12    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 392˙687.00
13    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 383˙622.00
14    KING'S COLLEGE LONDON UK (LONDON) participant 325˙891.00
15    ABBOTT DIABETES CARE US (ALAMEDA) participant 0.00
16    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
17    FEDERATION INTERNATIONALE DU DIABETE BE (BRUXELLES) participant 0.00
18    JDRF INTERNATIONAL US (NEW YORK) participant 0.00
19    MEDTRONIC INTERNATIONAL TRADING SARL CH (TOLOCHENAZ) participant 0.00
20    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00
21    SANOFI-AVENTIS DEUTSCHLAND GMBH DE (FRANKFURT AM MAIN) participant 0.00
22    THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST US (NEW YORK) participant 0.00
23    UNITIO INC US (BOSTON) participant 0.00

Map

 Project objective

Diabetes is one of the most prevalent global non-communicable diseases, affecting 60 million people in Europe, 10% of whom with type 1 diabetes. Normalising elevated glucose levels decreases symptoms, prevents microvascular complications, improves cardiovascular health and saves lives, but creates a significant risk for hypoglycaemia when insulin treatment is required. Hypoglycaemia is a serious event associated with cognitive decline, reduced quality of life, cardiovascular events and mortality. Hypoglycaemia remains the principal barrier to achieve glucose levels necessary to prevent diabetic complications of chronic hyperglycaemia. The overall objective of Hypo-RESOLVE is to alleviate the burden and consequences of hypoglycaemia, to be achieved by answering several key questions through a unique public-private partnership. Hypo-RESOLVE will construct secure sustainable databases with data from 100-150 clinical trials offering huge statistical power to establish the glucose threshold(s) below which hypoglycaemia constitutes a risk for poor outcomes in various populations. This will provide valuable input for an evidence based classification of hypoglycaemia to be adopted by regulators, patient organisations and other stakeholders, for application in future trials, the clinic and epidemiologic studies. The basic science and translational research line of Hypo-RESOLVE will advance our understanding on mechanisms underlying consequences of hypoglycaemia and explore novel pathways for the restoration of impaired awareness of hypoglycaemia. Finally, we will determine the significance of CGM-detected low glucose and investigate psychological and economic impacts of hypoglycaemia to quantify the burden of hypoglycaemia both for the individual and next-of-kin, as well as for society. Altogether, Hypo-RESOLVE will importantly further our knowledge of hypoglycaemia, (facilitate to) reduce its burden and contribute to a better life for patients with insulin-treated diabetes

 Deliverables

List of deliverables.
Updated review of the evidence surrounding our proposed classification Documents, reports 2020-02-18 10:16:24
External Project Website Websites, patent fillings, videos etc. 2020-02-18 10:16:25
Hypo-RESOLVE Position Paper Documents, reports 2020-02-18 10:16:25

Take a look to the deliverables list in detail:  detailed list of Hypo-RESOLVE deliverables.

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The information about "HYPO-RESOLVE" are provided by the European Opendata Portal: CORDIS opendata.

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