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NanoBioNext SIGNED

Nanoscale Biomeasurements of Nerve Cells and Vesicles: Molecular Substructure and the Nature of Exocytosis

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EC-Contrib. €

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Project "NanoBioNext" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 2˙500˙000.00

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 Project objective

I propose to develop and apply state of the art analytical methods to investigate cell membrane and vesicle substructure to elucidate the chemistry of the closing regulatory phase of individual exocytosis events. The general goal of this proposal is to develop a new brand of analytical nanoelectrochemistry (nanogap and nanopore electrochemical cytometry), combined with chemical nanoscopy imaging methods with STED and nanoscale mass spectrometry imaging. I propose to apply this to the questions of the nature of exocytosis and the chemistry that initiates the process of a short-term memory. We have recently discovered that most neurotransmitter release is partial via an open and closed vesicle release process and this allows new mechanisms of plasticity and synaptic strength to be hypothesized. I propose to (i) test if partial release is ubiquitous phenomenon, (ii) develop new nanoscale analytical methods to measure exocytotic release from pancreatic beta cells and a neuron in Drosophila, and to elucidate the substructure of nanometer vesicles, (iii) use these analytical methods in model cells and neurons to test the hypothesis that lipid membrane changes are involved in the initiation of the chemical events leading to short-term memory, and (iv) test the effects of drugs and zinc on plasticity of vesicles and exocytosis. This work combines new method development with a revolutionary application of chemical analysis to test the hypothesis that lipids play a previously unanticipated role in synaptic plasticity and the chemical structures involved in the initiation of short-term memory. As long-term impact, this will provide sensitive analytical tools to understand how changes in these chemical species might be affected in relation to diseases involving short-term memory loss.

 Publications

year authors and title journal last update
List of publications.
2019 Stefanos Stagkourakis, Johan Dunevall, Zahra Taleat, Andrew G. Ewing, Christian Broberger
Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System
published pages: 4009-4022, ISSN: 0270-6474, DOI: 10.1523/jneurosci.2339-18.2019
The Journal of Neuroscience 39/21 2020-04-03
2020 Xin-Wei Zhang, Amir Hatamie, Andrew G. Ewing
Simultaneous Quantification of Vesicle Size and Catecholamine Content by Resistive Pulses in Nanopores and Vesicle Impact Electrochemical Cytometry
published pages: 4093-4097, ISSN: 0002-7863, DOI: 10.1021/jacs.9b13221
Journal of the American Chemical Society 142/9 2020-04-03
2020 Ibrahim Kaya, Eva Jennische, Johan Dunevall, Stefan Lange, Andrew G. Ewing, Per Malmberg, Ahmet Tarik Baykal, John S. Fletcher
Spatial Lipidomics Reveals Region and Long Chain Base Specific Accumulations of Monosialogangliosides in Amyloid Plaques in Familial Alzheimer’s Disease Mice (5xFAD) Brain
published pages: 14-24, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.9b00532
ACS Chemical Neuroscience 11/1 2020-04-03
2019 Anna Larsson, Soodabeh Majdi, Ricardo Borges, Andrew Ewing
Vesicular Transmitter Content in Chromaffin Cells Can Be Regulated via Extracellular ATP
published pages: 4735-4740, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.9b00494
ACS Chemical Neuroscience 10/11 2020-04-03
2019 Chaoyi Gu, Anna Larsson, Andrew G. Ewing
Plasticity in exocytosis revealed through the effects of repetitive stimuli affect the content of nanometer vesicles and the fraction of transmitter released
published pages: 21409-21415, ISSN: 0027-8424, DOI: 10.1073/pnas.1910859116
Proceedings of the National Academy of Sciences 116/43 2020-04-03
2019 Masoumeh Dowlatshahi Pour, Lin Ren, Eva Jennische, Stefan Lange, Andrew G. Ewing, Per Malmberg
Mass spectrometry imaging as a novel approach to measure hippocampal zinc
published pages: 1581-1587, ISSN: 0267-9477, DOI: 10.1039/c9ja00199a
Journal of Analytical Atomic Spectrometry 34/8 2020-04-03

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The information about "NANOBIONEXT" are provided by the European Opendata Portal: CORDIS opendata.

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