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HEALIGRAFT SIGNED

Synergistic growth factor microenvironments for veterinary bone regeneration.

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "HEALIGRAFT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙973 €
 EC max contribution 149˙973 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 149˙973.00

Map

 Project objective

We propose a system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering and have planned a veterinary trial in relevant conditions. We have teamed up with a team of veterinary surgeons and several industry and clinical partners for the appraisal of the proposal from a translational standpoint. rhBMP2 is a powerful growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organize FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered systems to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the systems safe, effective and more competitive than current commercial products. The pathway to human applications requires strong financial commitments. We will explore the veterinary application of our technology and also, because of the conditions treated, as a demonstration towards application in humans. Overall, we will develop a safe and versatile bone system for clinical use in joint arthodesis and non- union bone defects, and we will set a route towards commercialization.

 Publications

year authors and title journal last update
List of publications.
2019 Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, Vineetha Jayawarna, Peter Childs, David W. Shields, Marco Cantini, Laura Ruiz-Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby, Manuel Salmeron-Sanchez
Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects
published pages: 1800361, ISSN: 2198-3844, DOI: 10.1002/advs.201800361
Advanced Science 6/2 2020-04-04

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