B2B SIGNED
Modeling spontaneous Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity.
Total Cost €
0EC-Contrib. €
0Partnership
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0B2B project word cloud
Explore the words cloud of the B2B project. It provides you a very rough idea of what is the project "B2B" about.
Project "B2B" data sheet
The following table provides information about the project.
| Coordinator |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.b2bproject.eu |
| Total cost | 3˙799˙371 € |
| EC max contribution | 3˙799˙371 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-1-2016-2017 |
| Funding Scheme | RIA |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-07-01 to 2022-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CONSIGLIO NAZIONALE DELLE RICERCHE | IT (ROMA) | coordinator | 711˙887.00 |
| 2 | UNIVERSITAT BASEL | CH (BASEL) | participant | 1˙198˙345.00 |
| 3 | UNIVERSITEIT MAASTRICHT | NL (MAASTRICHT) | participant | 464˙383.00 |
| 4 | REACT4LIFE SRL | IT (GENOVA) | participant | 406˙600.00 |
| 5 | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | NL (ROTTERDAM) | participant | 390˙825.00 |
| 6 | CAMBRIDGE INNOVATION TECHNOLOGIES CONSULTING LIMITED | UK (CAMBRIDGE) | participant | 234˙242.00 |
| 7 | IN SRL | IT (UDINE) | participant | 230˙587.00 |
| 8 | BIOEMISSION TECHNOLOGY SOLUTIONS IKE | EL (ATHINA) | participant | 162˙500.00 |
Map
Project objective
Cancer patients developing a metastatic disease are considered incurable. Breast cancer hits 1 woman in 8, and its most common metastatic site is the bone. A major hurdle to overcome breast cancer mortality is the lack of understanding of dynamics leading to the spread of breast cancer cells to the bone. Consequently, metastasis-suppressing agents have not been found to date, neither as newly developed drugs nor as repurposing of existing ones. The aim of the B2B device is to generate a first-of-a-kind 3D model of spontaneous breast cancer metastasis to the bone to dissect the complexity of the metastatic process and empower high-throughput drug screening in a physiological context. B2B will pursue its goal of developing a novel hybrid device able to 1) propagate patient-derived tumor organoids of clinically-relevant dimensions, with their own self-assembled micro-capillary networks, which are 2) continuously linked to a 3D bioprinted macro-vascular tree, organized in a hierarchical branched structure, connected in a closed circuit with 3) a vascularized marrow-containing bone ossicle, as the metastatic target. This is a unique approach, spanning the micro (single circulating metastatic cells, passing the endothelial barrier of capillary networks) to macro (tumor organoids and ossicles of clinically relevant size and tissue composition, connected by a hierarchically organized vascular tree) continuum to recapitulate spontaneous bone metastasis formation in breast cancer. This technology will transcend the limitations of current in vitro technologies, enabling physiological tissue-level complexity with organoids comprising several million cells, and its expected impact will be three-fold: to recapitulate the spontaneous metastatic process in breast cancer, to provide a breakthrough technology to investigate metastasis longitudinally and at the single cell level, and to lead to the identification of metastasis-suppressing therapies for breast cancer patients.
Deliverables
| Website and logo | Websites, patent fillings, videos etc. | 2019-10-08 17:12:39 |
Take a look to the deliverables list in detail: detailed list of B2B deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilaria Alborelli, Luca Quagliata, Charlotte Ng, Salvatore Piscuoglio, Nicola Aceto Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations published pages: 31, ISSN: 2075-4418, DOI: 10.3390/diagnostics8020031 |
Diagnostics 8/2 | 2019-08-29 |
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