Explore the words cloud of the evFOUNDRY project. It provides you a very rough idea of what is the project "evFOUNDRY" about.
The following table provides information about the project.
CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE
|Coordinator Country||Italy [IT]|
|Total cost||2˙726˙516 €|
|EC max contribution||2˙726˙516 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2018-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE||IT (FIRENZE)||coordinator||639˙375.00|
|2||UNIVERSITY OF SOUTHAMPTON||UK (SOUTHAMPTON)||participant||449˙976.00|
|3||HANSABIOMED LIFE SCIENCES OU||EE (TALLINN)||participant||418˙000.00|
|4||AARHUS UNIVERSITET||DK (AARHUS C)||participant||417˙405.00|
|5||LUNDS UNIVERSITET||SE (LUND)||participant||401˙065.00|
|6||UNIVERSITEIT UTRECHT||NL (UTRECHT)||participant||400˙695.00|
Extracellular vesicles (EVs) are natural cell-derived nanoparticles containing bioactive proteins and RNAs, which are newly recognized as the universal agents of intercellular and inter-organismal communication, in both normal and pathological processes. EVs are reshaping our perspective on life sciences, environment and public health. They are under intensive investigation as early disease multi-biomarkers, while EV-based personalized therapeutic agents and vaccines have produced enticing results in early-phase clinical trials. However, EV exploitation is not supported by current manufacturing methods, which are inadequate in terms of purity and reproducibility or yield, time and cost. evFOUNDRY targets a breakthrough technology able to streamline production of therapeutic EVs from sustainable sources, drawing the baseline for future EV bioprocessing, which is necessary for effective EV medical translation (large clinical trials and regulatory initiatives) and provides access to new EV applications (nanotechnology, nutraceuticals, cosmeceuticals, veterinary). To meet the challenge, evFOUNDRY will unravel how EVs and EV fluids interact with surfaces and leverage it to develop the first device for continuous production of high-grade EVs from milk and parasites, which are the most promising scalable sources of EVs with immune modulatory properties. Major objectives include: (i) to determine the compositional, structural and colloidal properties of EVs that control their interaction with surfaces; (ii) to engineer nanostructured surfaces integrated in microfluidic devices for separation of EV populations that are homogeneous in size and/or membrane properties from bovine milk and Ascaris incubation media; (iii) to design an integrated modular-system for the reproducible separation and analysis of these EVs under continuous flow; (iv) to implement a lab-scale prototype for the continuous production of quality-compliant immune modulatory EVs.
|SOPs for quality standard nanosized EVs from bovine milk||Documents, reports||2020-04-11 08:53:16|
|Internal and main external communication channels||Websites, patent fillings, videos etc.||2020-04-11 08:53:16|
|Library of nano-DLD surfaces||Demonstrators, pilots, prototypes||2020-04-11 08:53:16|
|Library of nanostructured surfaces non-lamellar lipid phases||Demonstrators, pilots, prototypes||2020-04-11 08:53:16|
|Dissemination and communication plan||Documents, reports||2020-04-11 08:53:16|
|Project website online and logo||Websites, patent fillings, videos etc.||2020-04-11 08:53:16|
|SOPs for quality standard nanosized EVs from Ascaris media||Documents, reports||2020-04-11 08:53:16|
Take a look to the deliverables list in detail: detailed list of evFOUNDRY deliverables.
|year||authors and title||journal||last update|
Andrea Zendrini, Lucia Paolini, Sara Busatto, Annalisa Radeghieri, Miriam Romano, Marca H. M. Wauben, Martijn J. C. van Herwijnen, Peter Nejsum, Anne Borup, Andrea Ridolfi, Costanza Montis, Paolo Bergese
Augmented COlorimetric NANoplasmonic (CONAN) Method for Grading Purity and Determine Concentration of EV Microliter Volume Solutions
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00452
|Frontiers in Bioengineering and Biotechnology 7||2020-04-24|
S. Busatto, A. Zendrini, A. Radeghieri, L. Paolini, M. Romano, M. Presta, P. Bergese
The nanostructured secretome
published pages: 39-63, ISSN: 2047-4830, DOI: 10.1039/c9bm01007f
|Biomaterials Science 8/1||2020-04-11|
Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paolo Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta ErdbrÃ¼gger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Mat
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
published pages: 1684862, ISSN: 2001-3078, DOI: 10.1080/20013078.2019.1684862
|Journal of Extracellular Vesicles 8/1||2020-04-11|
Jason P. Beech, Kevin Keim, Bao Dang Ho, Carlotta Guiducci, Jonas O. Tegenfeldt
Active Posts in Deterministic Lateral Displacement Devices
published pages: 1900339, ISSN: 2365-709X, DOI: 10.1002/admt.201900339
|Advanced Materials Technologies||2020-04-11|
Sara Busatto, George Vilanilam, Taylor Ticer, Wen-Lang Lin, Dennis Dickson, Shane Shapiro, Paolo Bergese, Joy Wolfram
Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid
published pages: 273, ISSN: 2073-4409, DOI: 10.3390/cells7120273
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The information about "EVFOUNDRY" are provided by the European Opendata Portal: CORDIS opendata.