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evFOUNDRY SIGNED

The Extracellular Vesicle Foundry

Total Cost €

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EC-Contrib. €

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Partnership

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 evFOUNDRY project word cloud

Explore the words cloud of the evFOUNDRY project. It provides you a very rough idea of what is the project "evFOUNDRY" about.

device    newly    evs    public    vaccines    sustainable    surfaces    breakthrough    nutraceuticals    environment    ev    nanostructured    pathological    proteins    bioactive    medical    biomarkers    populations    therapeutic    clinical    cell    sources    trials    investigation    reproducibility    reproducible    flow    structural    ascaris    translation    quality    vesicles    lab    nanoparticles    engineer    fluids    intensive    natural    leverage    milk    extracellular    inadequate    cosmeceuticals    modular    membrane    containing    veterinary    organismal    colloidal    manufacturing    first    baseline    disease    inter    evfoundry    time    separation    perspective    normal    homogeneous    bioprocessing    grade    prototype    continuous    modulatory    scalable    health    parasites    interaction    compositional    yield    regulatory    immune    reshaping    microfluidic    universal    meet    compliant    interact    communication    enticing    life    purity    personalized    unravel    incubation    sciences    bovine    rnas    media    nanotechnology    agents    streamline    size    drawing    intercellular    provides   

Project "evFOUNDRY" data sheet

The following table provides information about the project.

Coordinator
CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE 

Organization address
address: VIA DELLA LASTRUCCIA 3
city: FIRENZE
postcode: 50019
website: www.csgi.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.evfoundry.eu
 Total cost 2˙726˙516 €
 EC max contribution 2˙726˙516 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE IT (FIRENZE) coordinator 639˙375.00
2    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) participant 449˙976.00
3    HANSABIOMED LIFE SCIENCES OU EE (TALLINN) participant 418˙000.00
4    AARHUS UNIVERSITET DK (AARHUS C) participant 417˙405.00
5    LUNDS UNIVERSITET SE (LUND) participant 401˙065.00
6    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 400˙695.00

Map

 Project objective

Extracellular vesicles (EVs) are natural cell-derived nanoparticles containing bioactive proteins and RNAs, which are newly recognized as the universal agents of intercellular and inter-organismal communication, in both normal and pathological processes. EVs are reshaping our perspective on life sciences, environment and public health. They are under intensive investigation as early disease multi-biomarkers, while EV-based personalized therapeutic agents and vaccines have produced enticing results in early-phase clinical trials. However, EV exploitation is not supported by current manufacturing methods, which are inadequate in terms of purity and reproducibility or yield, time and cost. evFOUNDRY targets a breakthrough technology able to streamline production of therapeutic EVs from sustainable sources, drawing the baseline for future EV bioprocessing, which is necessary for effective EV medical translation (large clinical trials and regulatory initiatives) and provides access to new EV applications (nanotechnology, nutraceuticals, cosmeceuticals, veterinary). To meet the challenge, evFOUNDRY will unravel how EVs and EV fluids interact with surfaces and leverage it to develop the first device for continuous production of high-grade EVs from milk and parasites, which are the most promising scalable sources of EVs with immune modulatory properties. Major objectives include: (i) to determine the compositional, structural and colloidal properties of EVs that control their interaction with surfaces; (ii) to engineer nanostructured surfaces integrated in microfluidic devices for separation of EV populations that are homogeneous in size and/or membrane properties from bovine milk and Ascaris incubation media; (iii) to design an integrated modular-system for the reproducible separation and analysis of these EVs under continuous flow; (iv) to implement a lab-scale prototype for the continuous production of quality-compliant immune modulatory EVs.

 Deliverables

List of deliverables.
SOPs for quality standard nanosized EVs from bovine milk Documents, reports 2020-04-11 08:53:16
Internal and main external communication channels Websites, patent fillings, videos etc. 2020-04-11 08:53:16
Library of nano-DLD surfaces Demonstrators, pilots, prototypes 2020-04-11 08:53:16
Library of nanostructured surfaces non-lamellar lipid phases Demonstrators, pilots, prototypes 2020-04-11 08:53:16
Dissemination and communication plan Documents, reports 2020-04-11 08:53:16
Project website online and logo Websites, patent fillings, videos etc. 2020-04-11 08:53:16
SOPs for quality standard nanosized EVs from Ascaris media Documents, reports 2020-04-11 08:53:16

Take a look to the deliverables list in detail:  detailed list of evFOUNDRY deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Andrea Zendrini, Lucia Paolini, Sara Busatto, Annalisa Radeghieri, Miriam Romano, Marca H. M. Wauben, Martijn J. C. van Herwijnen, Peter Nejsum, Anne Borup, Andrea Ridolfi, Costanza Montis, Paolo Bergese
Augmented COlorimetric NANoplasmonic (CONAN) Method for Grading Purity and Determine Concentration of EV Microliter Volume Solutions
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00452
Frontiers in Bioengineering and Biotechnology 7 2020-04-24
2020 S. Busatto, A. Zendrini, A. Radeghieri, L. Paolini, M. Romano, M. Presta, P. Bergese
The nanostructured secretome
published pages: 39-63, ISSN: 2047-4830, DOI: 10.1039/c9bm01007f
Biomaterials Science 8/1 2020-04-11
2019 Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paolo Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrügger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Mat
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
published pages: 1684862, ISSN: 2001-3078, DOI: 10.1080/20013078.2019.1684862
Journal of Extracellular Vesicles 8/1 2020-04-11
2019 Jason P. Beech, Kevin Keim, Bao Dang Ho, Carlotta Guiducci, Jonas O. Tegenfeldt
Active Posts in Deterministic Lateral Displacement Devices
published pages: 1900339, ISSN: 2365-709X, DOI: 10.1002/admt.201900339
Advanced Materials Technologies 2020-04-11
2018 Sara Busatto, George Vilanilam, Taylor Ticer, Wen-Lang Lin, Dennis Dickson, Shane Shapiro, Paolo Bergese, Joy Wolfram
Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid
published pages: 273, ISSN: 2073-4409, DOI: 10.3390/cells7120273
Cells 7/12 2020-04-11

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The information about "EVFOUNDRY" are provided by the European Opendata Portal: CORDIS opendata.

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