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HOPE SIGNED

Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6

Total Cost €

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EC-Contrib. €

0

Partnership

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 HOPE project word cloud

Explore the words cloud of the HOPE project. It provides you a very rough idea of what is the project "HOPE" about.

genomic    generation    entities    tools    reveal    screening    influence    employing    therapeutic    cancer    prerequisite    poorly    resistance    prevents    spread    supports    functional    preventive    limitations    lymphocyte    risk    cas9    startegies    genetic    immune    delineate    clinically    lung    potentially    pronged    inflammation    cell    events    mechanisms    predisposition    human    progression    pkc    proteomic    microenvironment    inseparable    distal    inhibitors    host    combination    immunological    team    epidemiologically    first    either    initiation    profoundly    signalling    chronic    reducing    site    overcome    tumour    therapy    immunity    node    axis    molecular    clinical    recurrence    successful    nsclc    transcriptomic    rejecting    strategies    elucidated    complexity    biological    cells    combinatorial    checkpoint    experimentally    tumours    mission    prevention    oncology    adverse    intrinsic    prevalent    biochemical    metastases    technologies    anti    effector    crossroads    perturbation    nr2f6    network    protective    organs    clinic    rendering    latter    crispr    pd    validate    signatures    shown    functions   

Project "HOPE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAT INNSBRUCK 

Organization address
address: CHRISTOPH PROBST PLATZ 1
city: INNSBRUCK
postcode: 6020
website: www.i-med.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 2˙484˙325 €
 EC max contribution 2˙484˙325 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAT INNSBRUCK AT (INNSBRUCK) coordinator 2˙484˙325.00

Map

 Project objective

'Because of its biological complexity, cancer is still poorly understood. Chronic inflammation has been shown, both experimentally and epidemiologically, to be a predisposition to, and also an inseparable aspect of clinically prevalent cancer entities. Therefore, a detailed understanding of both tumour and immune cell functions in cancer progression is a prerequisite for more successful therapeutic startegies. My team was the first to reveal the lymphocyte-intrinsic PKC/NR2F6 axis as an essential signalling node at the crossroads between inflammation and cancer. It is the mission of this project to identify molecular signatures that influence the risk of developing tumours employing established research tools and state-of-the-art genetic, biochemical, proteomic and transcriptomic as well as large scale CRISPR/Cas9 perturbation screening-based functional genomic technologies. Defining this as yet poorly elucidated effector pathway with its profoundly relevant role would enable development of preventive and immune-therapeutic strategies against NSCLC lung cancer and potentially also against other entities. Our three-pronged approach to achieve this goal is to: (i) delineate biological and clinical properties of the immunological PKC/NR2F6 network, (ii) validate NR2F6 as an immune-oncology combination target needed to overcome limitations to 'first generation anti-PD-1 checkpoint inhibitors' rendering T cells capable of rejecting tumours and their metastases at distal organs and (iii) exploit human combinatorial T cell therapy concepts for prevention of immune-related adverse events as well as of tumour recurrence by reducing opportunities for the tumour to develop resistance in the clinic. Insight into the functions of NR2F6 pathway and involved mechanisms is a prerequisite for understanding how the microenvironment at the tumour site either supports tumour growth and spread or prevents tumour initiation and progression, the latter by host-protective cancer immunity.'

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The information about "HOPE" are provided by the European Opendata Portal: CORDIS opendata.

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