Opendata, web and dolomites

DYNACOTINE SIGNED

Signal transduction and allosteric modulation of nicotinic acetylcholine receptors:from ion channel electrophysiology to atomic 3D structures

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DYNACOTINE project word cloud

Explore the words cloud of the DYNACOTINE project. It provides you a very rough idea of what is the project "DYNACOTINE" about.

receptors    functionally    wp2    wp1    acetylcholine    transitions    channel    conformations    purified    fluorescence    elusive    proteins    multidisciplinary    transmembrane    routes    opening    transmission    single    ion    multiple    motions    docking    underlying    modulation    functions    molecular    physiological    mediate    conformational    lipids    electrophysiology    membrane    biochemistry    unanticipated    ligand    display    expressed    silico    wp3       fundamental    synaptic    follow    time    centered    cells    resolution    alpha    insights    therapeutics    concomitant    revealed    innovative    quenching    date    pharmacology    pharmacological    structural    modulators    nicotinic    promises    acting    modeling    beta    crosstalk    reward    solved    technique    electrophysiological    gained    biology    structures    function    heteromeric    players    nachrs    gated    requirement    cell    protein    allosteric    plasticity    course    adopting    channels    domain    homomeric    brain    starting    nachr    hold    combines    neuronal    primarily    3d    therapeutic    dynamics    drug    mechanisms    structure    cognition    dissecting    original    shape   

Project "DYNACOTINE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙282˙105 €
 EC max contribution 2˙282˙105 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙282˙105.00

Map

 Project objective

Nicotinic acetylcholine receptors (nAChRs) mediate neuronal synaptic transmission and modulation. They contribute to higher brain functions such as cognition and reward and are important drug targets. Recent studies have revealed that these acetylcholine-gated ion channels display an unanticipated conformational plasticity, adopting multiple allosteric states that shape the time course of their electrophysiological response. To date, a single nAChR structure has been solved at high resolution, and our understanding of the conformational transitions remains so far elusive. To address this challenge, we propose to develop a top-down approach starting from the study of the conformational transitions of nAChRs functionally expressed in cells, and then dissecting the molecular mechanisms on purified proteins. In WP1, we will develop an innovative fluorescence quenching approach to follow the protein motions concomitant with channel opening at the cell membrane. In WP2, we will further exploit this technique on purified proteins, to study the role/requirement of lipids, and their pharmacological crosstalk with allosteric modulators acting at the transmembrane domain. In WP3, the gained knowledge will open original routes to solve 3D structures of nAChRs, in novel conformations and in complex with allosteric modulators. The research will be centered on the major brain nAChRs, primarily the homomeric α7 and also the heteromeric α4β2 nAChRs that are major physiological players and key potential therapeutic targets. This multidisciplinary project combines electrophysiology, fluorescence, pharmacology, membrane protein biochemistry and structural biology, together with in silico modeling, molecular dynamics and ligand docking. The results will provide fundamental insights into the allosteric mechanisms underlying both nAChR function and its modulation by allosteric modulators that hold promises in therapeutics.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DYNACOTINE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DYNACOTINE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

TAMING CORROSION (2020)

Towards mastering the long-standing challenge of ageing infrastructures in corrosive environments

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More