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EditMHC SIGNED

How MHC-I editing complexes shape the hierarchical immune response

Total Cost €

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EC-Contrib. €

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Partnership

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 EditMHC project word cloud

Explore the words cloud of the EditMHC project. It provides you a very rough idea of what is the project "EditMHC" about.

er    dynamic    place    class    precisely    chaperones    adaptive    encounters    reactions    architecture    single    risk    cytotoxic    orchestrates    our    presented    ultimately    transformation    immune    mechanistic    allomorphs    infected    sampling    released    molecules    erp57    complexes    elucidate    cancerous    immunity    unraveling    basis    dynamics    central    network    onto    strive    plc    epitopes    antigenic    principles    machinery    multisubunit    viral    proteasomal    assemblies    cellular    constantly    insights    multitasking    human    pave    antigen    proofreading    transporter    membrane    gain    peptides    assembly    calreticulin    editing    body    constitutes    stable    cell    tapasin    peptide    transport    coordinated    multiprotein    consequently    chaperone    mechanisms    quality    surveillance    macromolecular    health    mhc    cells    eliminate    oxidoreductase    degradation    pathogens    histocompatibility    tap    evasion    intracellular    loading    inner    surface    triggered    guarantees    scanned    malignant    diseases    tap1    lymphocytes    heterodimer    myriads    holistic    translocation   

Project "EditMHC" data sheet

The following table provides information about the project.

Coordinator
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN 

Organization address
address: THEODOR W ADORNO PLATZ 1
city: FRANKFURT AM MAIN
postcode: 60323
website: www.uni-frankfurt.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙181˙250 €
 EC max contribution 2˙181˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) coordinator 2˙181˙250.00

Map

 Project objective

Our body constantly encounters pathogens or malignant transformation. Consequently, the adaptive immune system is in place to eliminate infected or cancerous cells. Specific immune reactions are triggered by selected peptide epitopes presented on major histocompatibility complex class I (MHC-I) molecules, which are scanned by cytotoxic T lymphocytes.

Intracellular transport, loading, and editing of antigenic peptides onto MHC-I are coordinated by a highly dynamic multisubunit peptide-loading complex (PLC) in the ER membrane. This multitasking machinery orchestrates the translocation of proteasomal degradation products into the ER as well as the loading and proofreading of MHC-I molecules. Sampling of myriads of different peptide/MHC-I allomorphs requires a precisely coordinated quality control network in a single macromolecular assembly, including the transporter associated with antigen processing TAP1/2, the MHC-I heterodimer, the oxidoreductase ERp57, and the ER chaperones tapasin and calreticulin. Proofreading by MHC-I editing complexes guarantees that only very stable peptide/MHC-I complexes are released to the cell surface.

This proposal aims to gain a holistic understanding of the PLC and MHC-I proofreading complexes, which are essential for cellular immunity. We strive to elucidate the mechanistic basis of the antigen translocation complex TAP as well as the MHC-I chaperone complexes within the PLC. This high-risk/high-gain project will define the inner working of the PLC, which constitutes the central machinery of immune surveillance in health and diseases. The results will provide detailed insights into the architecture and dynamics of the PLC and will ultimately pave the way for unraveling general principles of intracellular membrane-embedded multiprotein assemblies in the human body. Furthermore, we will deliver a detailed understanding of mechanisms at work in viral immune evasion.

 Publications

year authors and title journal last update
List of publications.
2019 Susanne Hofmann, Dovile Januliene, Ahmad R. Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T. Kuhn, Eric R. Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller
Conformation space of a heterodimeric ABC exporter under turnover conditions
published pages: 580-583, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1391-0
Nature 571/7766 2020-01-30

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