Explore the words cloud of the E-T1IFNs project. It provides you a very rough idea of what is the project "E-T1IFNs" about.
The following table provides information about the project.
THE UNIVERSITY OF EDINBURGH
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙418˙800 €|
|EC max contribution||2˙418˙800 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-11-01 to 2023-10-31|
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|1||THE UNIVERSITY OF EDINBURGH||UK (EDINBURGH)||coordinator||2˙418˙800.00|
Type I interferons represent both key molecules in anti-viral defence and mediators of inflammatory disease, so that the induction, transmission and resolution of the interferon response are tightly regulated - balancing protection against infection versus the risk of immunopathology. Monogenic type I interferonopathies (T1IFNs), and related ‘complex’ phenotypes such as systemic lupus erythematosus and dermatomyositis, represent examples of a disturbance of the homeostatic control of this system, where a constitutive upregulation of type I interferon activity is considered directly relevant to pathology.
Set against the absence of a routine assay in clinical medicine for the detection of upregulated type I interferon, the current application addresses major questions in the developing T1IFN field. Analogous to other screening strategies (e.g. using mouse ENU mutagenesis or yeast gene deletion series), we have established a pipeline for the systematic identification of human mutant states predisposing to upregulated type I interferon signalling. Such an approach will allow for the comprehensive definition of important themes in interferon biology, informing our understanding of anti-viral signalling and self-non-self discrimination. Furthermore, these studies will have direct translational benefit - since the identification of a phenotype as a T1IFN implies the possibility of therapy to reduce type I interferon levels and / or block interferon signalling.
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The information about "E-T1IFNS" are provided by the European Opendata Portal: CORDIS opendata.