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ReCaP SIGNED

Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Total Cost €

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EC-Contrib. €

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Partnership

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 ReCaP project word cloud

Explore the words cloud of the ReCaP project. It provides you a very rough idea of what is the project "ReCaP" about.

printing    function    manufacturing    limited    overcome    wealth    injured    cell    live    injuries    infiltration    nanomedicine    bearing    degeneration    lab    articular    functionalised    rapid    shifting    micrornas    pore    subchondral    cells    viral    acids    pioneering    ultimately    treatments    mechanical    structure    3d    utilising    surface    adult    regions    undergo    recognised    surfacing    integration    direct    nucleic    cartilage    biomaterials    calcified    mediated    zonal    dna    regenerate    area    composition    bioactive    retention    maintaining    hypertrophy    intermediate    solution    initially    damaged    surgical    hype    platform    leads    building    paradigm    disruptive    capacity    directing    therapies    anchored    tissue    biomaterial    region    hyaline    vascularised    internationally    scaffold    revolutionise    architecture    host    joint    stem    osteoarthritis    repair    recap    procedure    restoration    encourage    experiences    printed    stable    failed    layered    load    had    bone    plasmid   

Project "ReCaP" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 2˙999˙410 €
 EC max contribution 2˙999˙410 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 2˙999˙410.00

Map

 Project objective

Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint, problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity. Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy. Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone. Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the damaged joint through a joint surfacing approach. The proposed ReCaP platform is thus a paradigm shifting disruptive technology that will revolutionise the way joint injuries are treated.

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The information about "RECAP" are provided by the European Opendata Portal: CORDIS opendata.

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