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ReCaP SIGNED

Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Total Cost €

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EC-Contrib. €

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Partnership

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 ReCaP project word cloud

Explore the words cloud of the ReCaP project. It provides you a very rough idea of what is the project "ReCaP" about.

rapid    bioactive    structure    surgical    3d    pioneering    bone    overcome    tissue    nanomedicine    hyaline    host    pore    adult    biomaterial    bearing    paradigm    viral    wealth    stable    utilising    manufacturing    articular    vascularised    procedure    platform    scaffold    mediated    shifting    biomaterials    direct    treatments    regions    area    cell    cartilage    experiences    undergo    failed    capacity    printing    internationally    directing    surface    encourage    leads    limited    recognised    plasmid    dna    initially    surfacing    injured    acids    injuries    mechanical    layered    maintaining    printed    regenerate    hype    retention    therapies    repair    disruptive    intermediate    solution    damaged    hypertrophy    joint    calcified    degeneration    region    live    revolutionise    integration    infiltration    stem    had    subchondral    cells    micrornas    nucleic    anchored    recap    ultimately    zonal    lab    architecture    function    load    osteoarthritis    restoration    building    composition    functionalised   

Project "ReCaP" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 2˙999˙410 €
 EC max contribution 2˙999˙410 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 2˙999˙410.00

Map

 Project objective

Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint, problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity. Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy. Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone. Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the damaged joint through a joint surfacing approach. The proposed ReCaP platform is thus a paradigm shifting disruptive technology that will revolutionise the way joint injuries are treated.

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The information about "RECAP" are provided by the European Opendata Portal: CORDIS opendata.

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