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ReCaP SIGNED

Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Total Cost €

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EC-Contrib. €

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Partnership

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 ReCaP project word cloud

Explore the words cloud of the ReCaP project. It provides you a very rough idea of what is the project "ReCaP" about.

leads    surgical    tissue    pioneering    procedure    printed    mechanical    utilising    revolutionise    integration    limited    vascularised    capacity    osteoarthritis    wealth    plasmid    lab    stem    injured    composition    hypertrophy    nanomedicine    recognised    regenerate    micrornas    infiltration    scaffold    solution    bioactive    calcified    undergo    3d    cell    viral    surface    load    acids    disruptive    biomaterial    live    mediated    anchored    therapies    initially    dna    host    printing    hype    ultimately    functionalised    restoration    adult    shifting    layered    hyaline    articular    injuries    cells    stable    architecture    regions    encourage    biomaterials    intermediate    joint    damaged    bearing    subchondral    repair    had    platform    function    zonal    nucleic    maintaining    direct    paradigm    directing    rapid    experiences    treatments    region    surfacing    bone    recap    cartilage    structure    building    degeneration    retention    internationally    overcome    area    failed    pore    manufacturing   

Project "ReCaP" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 2˙999˙410 €
 EC max contribution 2˙999˙410 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 2˙999˙410.00

Map

 Project objective

Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint, problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity. Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy. Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone. Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the damaged joint through a joint surfacing approach. The proposed ReCaP platform is thus a paradigm shifting disruptive technology that will revolutionise the way joint injuries are treated.

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The information about "RECAP" are provided by the European Opendata Portal: CORDIS opendata.

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