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SMARTRIOX SIGNED

Disruptive targeted drug delivery system via synergistic combination of intelligent DNA molecular machines and gated mesoporous nanoparticles

Total Cost €

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EC-Contrib. €

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Partnership

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 SMARTRIOX project word cloud

Explore the words cloud of the SMARTRIOX project. It provides you a very rough idea of what is the project "SMARTRIOX" about.

dose    txn770    interval    cells    releases    course    ease    patients    although    limit    toxicities    200    anthracycline    bcs    causes    times    progesterone    adjuvant    grow    settings    treatment    2021    receptors    invested    endocrine    company    potent    disease    positioning    primarily    nano    substantial    free    triox    programmed    market    itself    doxorubicin    oncologists    15    epithelial    levels    helpful    25    anticancer    digestive    resistant    exclusively    negative    machine    cap    lower    diagnosis    recognizes    mainstay    dnazyme    responding    trioxnano    lacks    effectiveness    render    molecular    shortened    547m    prognosis    threshold    health    estrogen    yearly    roi    chemotherapy    extremely    mg2    economic    diagnosed    suffering    breast    inside    nonetheless    bc    atp    accounts    setting    poor    neoadjuvant    metastatic    17    bionanoparticle    prevents    shows    maximal    profit    primary    date    burden    tnbc    cardiac    concentrations    10    cancer    innovative    national    achieves    women    world    therapies    aggressive    herceptin    orphan    immune    services    billion    ttriple    turn    tumour   

Project "SMARTRIOX" data sheet

The following table provides information about the project.

Coordinator
TRIOX NANO LTD 

Organization address
address: ROKACH SHIMON 4
city: JERUSALEM
postcode: 9518705
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.smartriox.com
 Total cost 2˙847˙667 €
 EC max contribution 1˙993˙367 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TRIOX NANO LTD IL (JERUSALEM) coordinator 1˙993˙367.00

Map

 Project objective

Although there are tTriple Negative Breast Cancer (TNBC), the most aggressive type of Breast Cancer (BC), accounts for 15-25% of all BCs. Yearly 200,000 women are diagnosed with TNBC, of which 100,000 are diagnosed with metastatic disease at the primary diagnosis. TNBC lacks a recognized molecular target, making it an orphan disease: no effective treatment is available to date. The poor prognosis of patients suffering from TNBC makes it extremely challenging for both oncologists and patients. TNBC is more aggressive because all its receptors (Estrogen/Progesterone/Herceptin) are negative, and targeted and endocrine therapies are not helpful. TNBC shows a shortened disease-free interval in the neoadjuvant and adjuvant settings and a more aggressive course in the metastatic setting.The mainstay treatment for TNBC is Doxorubicin, a potent anthracycline chemotherapy, which nonetheless, has substantial toxicities (cardiac, immune, digestive and epithelial) that limit its maximal dose and render the tumour cells resistant to it. As a result, patients cannot be treated with a high enough and effective dose.In response, Triox Nano has developed TXN770: an innovative bionanoparticle based anticancer treatment. TXN770 has a DNAzyme machine cap that recognizes cancer cells and releases the chemotherapy exclusively inside them, responding to pre-programmed threshold levels of Mg2 and ATP that are present primarily at the target TNBC cells. This allows using 4 times lower concentrations of Doxorubicin, which in turn causes less side effects and achieves a higher effectiveness. It also prevents cancer cells from becoming resistant to Doxorubicin.TrioxNano will address a BC world market of $10.4 billion, expected to grow to $17.2 billion in 2021. TrioxNano projects €547M in profit, with a ROI of €15 per euro invested in the project and in turn will help ease the economic burden of TNBC in National Health Services while positioning itself as a leading company in treatment of TNBC.

 Deliverables

List of deliverables.
Project Web page Websites, patent fillings, videos etc. 2020-01-14 14:23:12

Take a look to the deliverables list in detail:  detailed list of SMARTRIOX deliverables.

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The information about "SMARTRIOX" are provided by the European Opendata Portal: CORDIS opendata.

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