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SMARTRIOX SIGNED

Disruptive targeted drug delivery system via synergistic combination of intelligent DNA molecular machines and gated mesoporous nanoparticles

Total Cost €

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EC-Contrib. €

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Partnership

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 SMARTRIOX project word cloud

Explore the words cloud of the SMARTRIOX project. It provides you a very rough idea of what is the project "SMARTRIOX" about.

exclusively    lower    billion    women    547m    200    diagnosis    programmed    chemotherapy    anthracycline    patients    burden    concentrations    diagnosed    machine    mg2    national    invested    bcs    atp    accounts    effectiveness    neoadjuvant    primary    shows    releases    maximal    shortened    ttriple    bc    yearly    digestive    responding    market    extremely    oncologists    free    herceptin    receptors    15    nonetheless    cap    mainstay    cancer    turn    grow    disease    molecular    achieves    trioxnano    10    date    prognosis    tumour    toxicities    nano    2021    health    profit    positioning    cardiac    orphan    settings    render    course    world    services    potent    times    limit    25    bionanoparticle    adjuvant    causes    suffering    17    progesterone    levels    company    endocrine    primarily    immune    cells    epithelial    triox    treatment    tnbc    inside    recognizes    therapies    lacks    innovative    helpful    metastatic    ease    negative    setting    roi    estrogen    breast    poor    prevents    dnazyme    resistant    interval    although    economic    anticancer    substantial    txn770    dose    doxorubicin    threshold    aggressive    itself   

Project "SMARTRIOX" data sheet

The following table provides information about the project.

Coordinator
TRIOX NANO LTD 

Organization address
address: ROKACH SHIMON 4
city: JERUSALEM
postcode: 9518705
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.smartriox.com
 Total cost 2˙847˙667 €
 EC max contribution 1˙993˙367 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TRIOX NANO LTD IL (JERUSALEM) coordinator 1˙993˙367.00

Map

 Project objective

Although there are tTriple Negative Breast Cancer (TNBC), the most aggressive type of Breast Cancer (BC), accounts for 15-25% of all BCs. Yearly 200,000 women are diagnosed with TNBC, of which 100,000 are diagnosed with metastatic disease at the primary diagnosis. TNBC lacks a recognized molecular target, making it an orphan disease: no effective treatment is available to date. The poor prognosis of patients suffering from TNBC makes it extremely challenging for both oncologists and patients. TNBC is more aggressive because all its receptors (Estrogen/Progesterone/Herceptin) are negative, and targeted and endocrine therapies are not helpful. TNBC shows a shortened disease-free interval in the neoadjuvant and adjuvant settings and a more aggressive course in the metastatic setting.The mainstay treatment for TNBC is Doxorubicin, a potent anthracycline chemotherapy, which nonetheless, has substantial toxicities (cardiac, immune, digestive and epithelial) that limit its maximal dose and render the tumour cells resistant to it. As a result, patients cannot be treated with a high enough and effective dose.In response, Triox Nano has developed TXN770: an innovative bionanoparticle based anticancer treatment. TXN770 has a DNAzyme machine cap that recognizes cancer cells and releases the chemotherapy exclusively inside them, responding to pre-programmed threshold levels of Mg2 and ATP that are present primarily at the target TNBC cells. This allows using 4 times lower concentrations of Doxorubicin, which in turn causes less side effects and achieves a higher effectiveness. It also prevents cancer cells from becoming resistant to Doxorubicin.TrioxNano will address a BC world market of $10.4 billion, expected to grow to $17.2 billion in 2021. TrioxNano projects €547M in profit, with a ROI of €15 per euro invested in the project and in turn will help ease the economic burden of TNBC in National Health Services while positioning itself as a leading company in treatment of TNBC.

 Deliverables

List of deliverables.
Project Web page Websites, patent fillings, videos etc. 2020-01-14 14:23:12

Take a look to the deliverables list in detail:  detailed list of SMARTRIOX deliverables.

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The information about "SMARTRIOX" are provided by the European Opendata Portal: CORDIS opendata.

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