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ReSOLUTE SIGNED

Research empowerment on solute carriers (ReSOLUTE)

Total Cost €

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EC-Contrib. €

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Partnership

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 ReSOLUTE project word cloud

Explore the words cloud of the ReSOLUTE project. It provides you a very rough idea of what is the project "ReSOLUTE" about.

validated    institut    data    systematic    medizinische    spa    establishing    standards    genomic    cover    antibodies    super    lines    carriers    et    ingelheim    transform    knowledgebase    boehringer    binders    empowerment    cemm    sanofi    formats    planck    coupling    assay    generation    variety    pfizer    ag    inducing    uk    landscape    novartis    worldwide    elected    grade    uuml    wien    slc    proteomics    pharma    forschung    univ    engineering    networks    proteins    decisive    oxford    parallel    max    class    academic    leiden    industry    functional    aventis    central    systematically    six    genetic    veloppement    strategy    sme    complementary    resolute    industrial    redundant    connections    gene    solute    list    vifor    affinity    axxam    suitability    accessed    tools    repositories    seven    acceleration    certain    bayer    slcs    network    merges    hardware    goals    expertise    family    time    datasets    eacute    metabolomics    cell    manner    collection    core    omics    interlinked    intensity    plan    tractable    combining    recherche    manchester    group    drug    members    limited    deorphanisation    prioritized   

Project "ReSOLUTE" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://re-solute.eu/
 Total cost 23˙850˙000 €
 EC max contribution 12˙000˙000 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2016-10-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 6˙841˙011.00
2    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 1˙220˙266.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 1˙208˙850.00
4    AXXAM SPA IT (BRESSO MILANO) participant 1˙141˙250.00
5    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 723˙588.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 483˙750.00
7    UNIVERSITAT WIEN AT (WIEN) participant 379˙812.00
8    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 1˙470.00
9    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 0.00
10    BOEHRINGER INGELHEIM INTERNATIONALGMBH DE (INGELHEIM) participant 0.00
11    NOVARTIS PHARMA AG CH (BASEL) participant 0.00
12    PFIZER LIMITED UK (SANDWICH) participant 0.00
13    SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT FR (Chilly Mazarin) participant 0.00
14    VIFOR (INTERNATIONAL) AG CH (ST GALLEN) participant 0.00

Map

 Project objective

The Research empowerment on solute carriers (ReSOLUTE) proposal aims at inducing a decisive acceleration in the intensity of SLC research worldwide while establishing solute carriers (SLCs) as a tractable target class. It is composed of a core consortium of seven academic/SME members (CeMM, Univ. of Oxford, Univ. of Manchester, AXXAM Spa, Univ. Leiden, Max-Planck Institut für medizinische Forschung, Univ. Wien) and six industrial partners (Pfizer Limited UK, Novartis Pharma AG, Boehringer-Ingelheim, Vifor Pharma Group, Sanofi Aventis Recherche et Développement, Bayer AG) with established and complementary expertise combining industry grade standards and systems level principle-driven analysis.

ReSOLUTE merges systematic and focused approaches: 1) the generation of reliable and validated ‘hardware’ such as cell lines, proteins, antibodies/high affinity binders and large ‘omics’ datasets, 2) a central deorphanisation process coupling genomic engineering to metabolomics and supported by genetic and proteomics studies, 3) a non-redundant process to test systematically the suitability of a certain SLC to a variety of assay formats, 4) a collection of interlinked networks that cover different expertise, datasets and functional connections among SLCs, integrated into large-scale data repositories and a dedicated knowledgebase. The ReSOLUTE strategy will be applied in parallel at the super-family level and, in a more in-depth manner, to a prioritized gene list elected to be potential drug targets. To implement this and achieve the expected goals, the consortium is supported by a large network of academic and industrial partners with specific knowledge of certain SLCs and tools, willing to be accessed at any time and provide specific expertise. Together with a strong dissemination and exploitation plan, we therefore expect that ReSOLUTE will transform the landscape of SLC research for years to come.

 Deliverables

List of deliverables.
ReSOLUTE knowledgebase Documents, reports 2020-04-14 17:13:23
ReSOLUTE database Websites, patent fillings, videos etc. 2020-04-14 17:13:23
Data Management Plan 1 Documents, reports 2020-04-14 17:13:23
Data Mining Documents, reports 2020-04-14 17:13:23
Vector generation Documents, reports 2020-04-14 17:13:23

Take a look to the deliverables list in detail:  detailed list of ReSOLUTE deliverables.

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The information about "RESOLUTE" are provided by the European Opendata Portal: CORDIS opendata.

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