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EASYFISH SIGNED

Development of a new biomolecule to better control reproduction in fish

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EASYFISH project word cloud

Explore the words cloud of the EASYFISH project. It provides you a very rough idea of what is the project "EASYFISH" about.

spontaneously reproductive sea treatment world binding reproduction freshwater bovine 34 steroidogenic circulating trout lh efficient market oocyte environment mammals ovulation sustainable induce reliably injected supplies rp001 monoclonal free hormone spermiation potentiating rate injection consumers hormonal first females nevertheless farming endogenous ie spermatogenesis rat hatchery consumption manipulations issue contrast rp01 acts solution female maturation disrupting salmon farmed fishing innovative 8 stimulate antibody repropharm special male efficiency marine vet fsh porcine bass occursin eggs conventional fish exogenous potentiate species class males soon treatments operations fertilized hormones tool efficacy induces natural carp added captivity bream polyovulating source spontaneous ovine therapies egg fragment

Project "EASYFISH" data sheet

The following table provides information about the project.

Coordinator	REPROPHARM VET Organization address address: CENTRE INRA VAL DE LOIRE SITE DE TOURS city: NOUZILLY postcode: 37380 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.repropharmvet.com
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2018
Duration (year-month-day)	from 2018-08-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	REPROPHARM VET REPROPHARM VET Organization address address: CENTRE INRA VAL DE LOIRE SITE DE TOURS city: NOUZILLY postcode: 37380 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NOUZILLY)	coordinator	50˙000.00

Map

Project objective

'Fish farming is growing at 8% a year and will soon be the main source of fish for consumers. It supplies more than 34% of the world's fish consumption. Nevertheless, due to captivity environment some species have reproduction problems with no spontaneous ovulation in females and no spermiation in males. In some farmed freshwater species (ie, Carp, Salmon, Trout) and marine species (ie, Sea bass, Sea bream) the growth phase of reproductive development occursin captivity in contrast to oocyte maturation and ovulation in females, and spermiation in males that do not occur spontaneously. This problem requires exogenous hormonal therapies which are the only way to produce fertilized eggs reliably. In other species, these hormonal manipulations are used only as a management tool to enhance the efficiency of egg production, increase spermiation and facilitate hatchery operations. ReproPharm Vet developed a first in class monoclonal antibody RP01 and its fragment RP001, that are able to potentiate the activity of endogenous FSH and LH in mammals such as rat, bovine, ovine, porcine species. RP001 fragment can induce ovulation in female and stimulate spermatogenesis in male without any exogenous hormone injection. When injected, it acts directly on circulating FSH and LH hormones by binding to them and potentiating their activity. RP001 is more effective than conventional hormonal treatments it induces a better ovulation rate in polyovulating species and a better steroidogenic response in every species. Treatment with potentiating RP001 would be a highly innovative solution, hormone free, which could be a disrupting product in fishing market if we demonstrate its efficacy on fish FSH and LH. Its added value would be a more efficient method to induce ovulation and spermatogenesis without any exogenous hormone injection. RP001 would be a 'must-have' product to better control fish reproduction in a natural and sustainable way that represents a special issue on environment. '

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