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ENDONANO SIGNED

Quantitative detection of bacterial endotoxin by novel nanotechnological approaches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ENDONANO project word cloud

Explore the words cloud of the ENDONANO project. It provides you a very rough idea of what is the project "ENDONANO" about.

fluids    primary    intense    human    commercialisation    courses    safety    prone    designing    endotoxin    interference    technological    public    planning    regulatory    capacity    specialised    smes    academic    overarching    capture    biotech    diagnostic    goals    encompasses    functions    nanoparticles    events    participant    assay    generation    medical    beacons    participation    education    assays    expert    implementing    inflammation    gels    nanotechnological    detect    active    reactions    levels    cells    adsorb    quantitative    matrices    toxicological    metal    modulating    endonano    nanotechnology    detection    bacterial    networking    magnetic    emulsions    lal    intersectoral    drug    company    commercial    proven    biological    prototypes    training    validated    scientific    inflammatory    signal    quantitatively    blood    unbiased    train    students    purposes    microbead    phd    molecular    expertise    transferrable    skills    inducing    issue    substances    limited    biosensing   

Project "ENDONANO" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙035˙462 €
 EC max contribution 1˙035˙462 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-EID
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 261˙499.00
2    MILTENYI BIOTEC GMBH DE (BERGISH GLADBACH) participant 252˙788.00
3    BLUSENSE DIAGNOSTICS APS DK (KOBENHAVN) participant 148˙761.00
4    PARIS-LODRON-UNIVERSITAT SALZBURG AT (SALZBURG) participant 132˙103.00
5    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 125˙452.00
6    DIAGNOSTICUM GYARTO ES FORGALMAZO ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 114˙857.00
7    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) partner 0.00
8    APPLIED NANOPARTICLES SL ES (BARCELONA) partner 0.00

Map

 Project objective

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of diagnostic detection assays and one biotech company specialised in (magnetic) microbead technology, and two Participant Organisations (SMEs). All have proven experience in higher education and training,

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The information about "ENDONANO" are provided by the European Opendata Portal: CORDIS opendata.

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