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ENDONANO SIGNED

Quantitative detection of bacterial endotoxin by novel nanotechnological approaches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ENDONANO project word cloud

Explore the words cloud of the ENDONANO project. It provides you a very rough idea of what is the project "ENDONANO" about.

interference    endonano    generation    detect    adsorb    cells    functions    capacity    quantitative    bacterial    phd    reactions    beacons    networking    commercialisation    students    participation    planning    commercial    inflammation    intersectoral    designing    specialised    technological    substances    inflammatory    assays    endotoxin    gels    expert    capture    metal    goals    fluids    transferrable    drug    smes    medical    validated    matrices    nanoparticles    proven    diagnostic    detection    prototypes    academic    implementing    intense    toxicological    train    lal    blood    courses    human    magnetic    emulsions    events    inducing    training    levels    participant    regulatory    scientific    issue    purposes    microbead    unbiased    expertise    biosensing    limited    quantitatively    nanotechnology    overarching    education    biological    nanotechnological    signal    company    safety    encompasses    primary    prone    assay    modulating    biotech    skills    public    active    molecular   

Project "ENDONANO" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙035˙462 €
 EC max contribution 1˙035˙462 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-EID
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 261˙499.00
2    MILTENYI BIOTEC GMBH DE (BERGISH GLADBACH) participant 252˙788.00
3    BLUSENSE DIAGNOSTICS APS DK (KOBENHAVN) participant 148˙761.00
4    PARIS-LODRON-UNIVERSITAT SALZBURG AT (SALZBURG) participant 132˙103.00
5    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 125˙452.00
6    DIAGNOSTICUM GYARTO ES FORGALMAZO ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 114˙857.00
7    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) partner 0.00
8    APPLIED NANOPARTICLES SL ES (BARCELONA) partner 0.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of diagnostic detection assays and one biotech company specialised in (magnetic) microbead technology, and two Participant Organisations (SMEs). All have proven experience in higher education and training,

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The information about "ENDONANO" are provided by the European Opendata Portal: CORDIS opendata.

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