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ENDONANO SIGNED

Quantitative detection of bacterial endotoxin by novel nanotechnological approaches

Total Cost €

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EC-Contrib. €

0

Partnership

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ENDONANO project word cloud

Explore the words cloud of the ENDONANO project. It provides you a very rough idea of what is the project "ENDONANO" about.

human networking metal generation lal commercialisation matrices nanotechnological blood education events levels goals students molecular commercial regulatory functions prototypes modulating nanotechnology drug phd scientific inducing validated purposes interference participant capture primary quantitatively substances medical academic biosensing planning designing issue diagnostic nanoparticles signal limited train technological beacons specialised expertise prone skills endotoxin courses assay microbead intersectoral intense safety encompasses transferrable training fluids unbiased inflammatory company cells detect public magnetic overarching bacterial emulsions toxicological active endonano biological assays detection quantitative reactions expert adsorb capacity inflammation gels participation smes biotech implementing proven

Project "ENDONANO" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	1˙035˙462 €
EC max contribution	1˙035˙462 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2018
Funding Scheme	MSCA-ITN-EID
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	261˙499.00
2	MILTENYI BIOTEC GMBH MILTENYI BIOTEC GMBH Organization address address: FRIEDRICH EBERT STRASSE 68 city: BERGISH GLADBACH postcode: 51429 website: www.miltenyibiotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERGISH GLADBACH)	participant	252˙788.00
3	BLUSENSE DIAGNOSTICS APS BLUSENSE DIAGNOSTICS APS Organization address address: FRUEBJERGVEJ 3 city: KOBENHAVN postcode: 2100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	148˙761.00
4	PARIS-LODRON-UNIVERSITAT SALZBURG PARIS-LODRON-UNIVERSITAT SALZBURG Organization address address: KAPITELGASSE 4-6 city: SALZBURG postcode: 5020 website: www.uni-salzburg.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (SALZBURG)	participant	132˙103.00
5	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 website: www.icn.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BELLATERRA (BARCELONA))	participant	125˙452.00
6	DIAGNOSTICUM GYARTO ES FORGALMAZO ZARTKORUEN MUKODO RESZVENYTARSASAG DIAGNOSTICUM GYARTO ES FORGALMAZO ZARTKORUEN MUKODO RESZVENYTARSASAG Organization address address: ATTILA U 126 city: BUDAPEST postcode: 1047 website: www.diagnosticumltd.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	114˙857.00
7	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 website: www.altaweb.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	partner	0.00
8	APPLIED NANOPARTICLES SL APPLIED NANOPARTICLES SL Organization address address: CALLE ALABA 88 city: BARCELONA postcode: 8018 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	partner	0.00

Map

Project objective

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of diagnostic detection assays and one biotech company specialised in (magnetic) microbead technology, and two Participant Organisations (SMEs). All have proven experience in higher education and training,

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