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ENDONANO SIGNED

Quantitative detection of bacterial endotoxin by novel nanotechnological approaches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ENDONANO project word cloud

Explore the words cloud of the ENDONANO project. It provides you a very rough idea of what is the project "ENDONANO" about.

microbead    unbiased    commercial    students    proven    networking    endotoxin    planning    intersectoral    inflammation    gels    education    implementing    regulatory    commercialisation    biological    cells    signal    beacons    nanotechnology    encompasses    overarching    company    goals    drug    participant    scientific    participation    biotech    quantitatively    nanoparticles    issue    emulsions    prone    toxicological    human    technological    safety    bacterial    modulating    skills    inducing    blood    events    capture    magnetic    assays    levels    purposes    inflammatory    quantitative    medical    interference    limited    validated    biosensing    fluids    specialised    training    reactions    intense    academic    transferrable    designing    assay    nanotechnological    expertise    endonano    diagnostic    public    functions    molecular    expert    detection    generation    detect    metal    active    prototypes    capacity    matrices    courses    train    phd    lal    smes    substances    primary    adsorb   

Project "ENDONANO" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙035˙462 €
 EC max contribution 1˙035˙462 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-EID
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 261˙499.00
2    MILTENYI BIOTEC GMBH DE (BERGISH GLADBACH) participant 252˙788.00
3    BLUSENSE DIAGNOSTICS APS DK (KOBENHAVN) participant 148˙761.00
4    PARIS-LODRON-UNIVERSITAT SALZBURG AT (SALZBURG) participant 132˙103.00
5    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 125˙452.00
6    DIAGNOSTICUM GYARTO ES FORGALMAZO ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 114˙857.00
7    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) partner 0.00
8    APPLIED NANOPARTICLES SL ES (BARCELONA) partner 0.00

Map

 Project objective

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of diagnostic detection assays and one biotech company specialised in (magnetic) microbead technology, and two Participant Organisations (SMEs). All have proven experience in higher education and training,

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The information about "ENDONANO" are provided by the European Opendata Portal: CORDIS opendata.

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