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PanINSULA

PanINSULA - The next first commercially sustainable and therapeutically effective beta cell therapy for diabetes

Total Cost €

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EC-Contrib. €

0

Partnership

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 PanINSULA project word cloud

Explore the words cloud of the PanINSULA project. It provides you a very rough idea of what is the project "PanINSULA" about.

prevalence    damage    steady    protection    day    unparalleled    pancryos    people    shortage    paninsula    fluctuations    implanted    efficient    beta    glucose    lifetime    manufacturability    clinically    cell    insulin    t1d    hpscs    severe    islets    disease    hyperglycemia    levels    emerged    patients    generating    diabetes    damaged    risk    unhealthy    ages    purity    donor    cure    kidney    keeping    nerve    islet    overweight    regulate    immune    cells    10    blindness    treatment    lifethreatening    commercially    amputations    therapy    scalability    limited    secretion    purification    transplantation    pluripotent    blood    technologies    replace    intensive    contrast    careful    mostly    competing    natural    hurdles    patented    care    inject    difficulties    premature    obesity    times    physical    last    positions    inactivity    cadaveric    complications    scalable    heart    lack    serious    cope       diet    accounts    self    chronic    time    death    automation    population    producing    safety    stem    final    sugar    permanent    region   

Project "PanINSULA" data sheet

The following table provides information about the project.

Coordinator
PANCRYOS IVS 

Organization address
address: OLE MAALOES VEJ 3
city: KOBENHAVN N
postcode: 2200
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.pancryos.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PANCRYOS IVS DK (KOBENHAVN N) coordinator 50˙000.00

Map

 Project objective

Prevalence of diabetes is increasing among all ages in the European Region, mostly due to increases in overweight and obesity, unhealthy diet and physical inactivity. Today there are about 60 M people with diabetes in the EU, of which Type 1 Diabetes (T1D) accounts for between 5% and 10%. T1D patients must cope with a lifetime of intensive self-care (testing their blood sugar levels several times a day to inject insulin when required) and the risk of premature death. Even with careful management T1D patients can still have difficulties keeping a steady blood glucose level and over time these lifethreatening fluctuations, especially the chronic high blood sugar levels (hyperglycemia), can cause serious complications including heart disease, blindness, kidney failure and amputations due to nerve damage. Currently there is no cure for T1D and no new significant development or permanent therapy for diabetes has emerged in the last 70 years. Islet transplantation while effective is not a scalable therapy and limited to only the most severe T1D patients due to the shortage of cadaveric donor islets. Recent advances in generating insulin producing beta cells from pluripotent stem cells (hPSCs), positions stem cell-based therapy as a promising treatment for a wider population of T1D patients. A stem cell based therapy would replace the damaged beta cells in the patients and allow for a natural production and secretion of insulin to regulate the blood glucose levels. To make stem cell therapy a clinically and commercially viable treatment in diabetes, the following technical hurdles need to be addressed: safety (lack of purity), cost-effective scalability, and lack of immune protection of the implanted cells. Pancryos patented technology, in contrast to other available competing technologies, enables both purification and automation ensuring unparalleled safety and cost-efficient scalability and manufacturability of the final cell product PanINSULA.

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The information about "PANINSULA" are provided by the European Opendata Portal: CORDIS opendata.

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