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VacPath SIGNED

Novel vaccine vectors to resist pathogen challenge

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VacPath project word cloud

Explore the words cloud of the VacPath project. It provides you a very rough idea of what is the project "VacPath" about.

hampers    barely    prophylactic    infection    uncover    combination    humans    models    molecular    esr    economies    cell    unravel    preclinical    private    possibilities    resistance    mediated    urging    mechanisms    vectors    trachomatis    nevertheless    vaccinate    globe    pathogen    transmitted    threat    industry    immune    vaccines    world    too    efficacy    generation    burden    cooperate    training    infections    stage    induction    intracellular    academia    raised    creative    vaccine    obligate    optimisation    plasmid    immunity    poses    virus    populations    perceived    danger    humoral    bacterial    imposed    disease    chlamydia    rapid    combated    academic    diverse    solutions    induce    vector    bacterium    sexually    antibiotics    health    insufficient    responsive    infectious    re    demand    enter    protective    exploited    scientists    back    force    frequently    cellular    construct    innovative    spread    underlying    pathogens    diseases    safe    ready    persistence    educate    ago    constant   

Project "VacPath" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙701˙874 €
 EC max contribution 2˙701˙874 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 531˙239.00
2    UNIVERSITAT BASEL CH (BASEL) participant 562˙553.00
3    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF DE (DUSSELDORF) participant 505˙576.00
4    STATENS SERUM INSTITUT DK (KOBENHAVN S) participant 297˙522.00
5    ABERA BIOSCIENCE AB SE (STOCKHOLM) participant 281˙982.00
6    MICROBIOTEC SRL IT (MONTERIGGIONI) participant 261˙499.00
7    UNIVERSITA DEGLI STUDI DI SIENA IT (SIENA) participant 261˙499.00
8    SCLAVO VACCINES ASSOCIATION IT (SIENA) partner 0.00

Map

 Project objective

Infectious diseases are a major burden and constant threat to European populations and economies. While barely perceived as a danger not too long ago, a combination of potential rapid spread of novel pathogens across the globe, antibiotics resistance, a come-back of “old” pathogens and persistence of yet to be combated pathogens has raised the demand for effective but safe vaccines. An example of a yet to be combated pathogen is the obligate intracellular bacterium Chlamydia trachomatis. This pathogen is the major cause of sexually transmitted bacterial disease in humans, and poses a world-wide health concern. While responsive to antibiotics, re-infections frequently occur, urging the need for a prophylactic vaccine. Nevertheless, insufficient knowledge on how to vaccinate against intracellular pathogens hampers the development of such vaccines. In the proposed project, 5 academic and 2 private partners will cooperate to educate early stage researchers (ESR) in the diverse aspects of novel vaccine development. ESR will design and construct innovative and safe virus-, bacterium-, and plasmid-based vaccine vectors that induce both cell-mediated and humoral immunity, to control infections with intracellular pathogens. They will test these vaccines and improve their efficacy in preclinical models of C. trachomatis infection, and unravel the cellular and molecular mechanisms underlying the induction of protective immune responses, to uncover possibilities for general vaccine vector optimisation. The end-result will be a new generation of safe vaccine vectors that can be exploited to vaccinate against C. trachomatis, and can be adapted to vaccinate against further intracellular pathogens of choice. Moreover, this project will educate a new generation of scientists that, through the offered, integrated training, will be ready to enter the European task force, in academia or industry, to find creative solutions to future pathogen-imposed challenges.

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The information about "VACPATH" are provided by the European Opendata Portal: CORDIS opendata.

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