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GEMMA SIGNED

Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr

Total Cost €

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EC-Contrib. €

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Partnership

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 GEMMA project word cloud

Explore the words cloud of the GEMMA project. It provides you a very rough idea of what is the project "GEMMA" about.

16    attempt    relation    generating    models    pro    paradigm    600    gemma    possibility    mechanistic    profile    families    pathogenesis    murine    risk    evaluation    followed    genome    prediction    modulate    functions    biospecimens    microbiota    combine    biomarkers    function    urine    omic    ultimately    link    progression    proved    infants    causing    shift    asd    abnormal    multiomic    interplay    re    autistic    immune    complete    biobank    outcome    modifications    treatment    samples    stools    identification    diagnostic    transplanted    disorders    epigenetic    prevention    stool    clinical    composition    birth    homeostasis    cohort    symbiotic    gut    microbiome    stratification    first    interception    spectrum    environmental    patient    tools    children    solid    intervention    suspected    disease    data    administration    manipulate    proband    dynamic    metabolic    phenotypes    personalized    exploited    onset    collected    blood    aid    mechanistically    recruited    time    prospectively    collect    saliva    barrier    human    humanized   

Project "GEMMA" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE EBRIS 

Organization address
address: VIA DE RENZI 1
city: SALERNO
postcode: 84125
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 14˙225˙757 €
 EC max contribution 14˙225˙757 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE EBRIS IT (SALERNO) coordinator 2˙035˙531.00
2    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 1˙663˙750.00
3    THE GENERAL HOSPITAL CORPORATION US (BOSTON MA) participant 1˙256˙468.00
4    AZIENDA SANITARIA LOCALE SALERNO IT (SALERNO) participant 1˙133˙375.00
5    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) participant 1˙060˙617.00
6    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 881˙116.00
7    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 832˙812.00
8    NUTRICIA RESEARCH BV NL (UTRECHT) participant 812˙423.00
9    JOHNS HOPKINS UNIVERSITY US (BALTIMORE) participant 747˙212.00
10    EUFORMATICS OY FI (ESPOO) participant 728˙437.00
11    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) participant 558˙125.00
12    MEDINOK SPA IT (VOLLA) participant 549˙375.00
13    BIO MODELING SYSTEMS OU BMSYSTEMS FR (Paris) participant 548˙125.00
14    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 544˙375.00
15    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 447˙762.00
16    THEOREO SRL IT (MONTECORVINO PUGLIANO) participant 426˙250.00
17    TAMPEREEN YLIOPISTO FI (TAMPERE) participant 0.00

Map

 Project objective

GEMMA will be the first project to combine a multi-omic approach with robust environmental data to exploit the analysis of the composition and function of the microbiome for personalized treatment and, ultimately, disease interception in infants at risk of Autistic Spectrum Disorders (ASD) . The project will provide solid mechanistic evidence of the disease onset and progression in relation to dynamic changes in abnormal gut microbiota causing epigenetic modifications controlling gut barrier and immune functions, based on the in-depth evaluation of 600 infants at risk observed from birth and followed over time. These data will be integrated with pre-clinical studies to mechanistically link human microbiota composition/function with clinical outcome through humanized murine models transplanted with stools obtained from the ASD proband patient of recruited families. The project will support novel personalized prediction (personalized treatment) and disease interception (prevention) approaches that attempt to modulate gut microbiota to re-establish/maintain immune homeostasis. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and the possibility to manipulate the microbiota through pre/pro/symbiotic administration for prevention and treatment, a complete paradigm shift in ASD pathogenesis and early intervention. The identification of specific ASD metabolic phenotypes will further aid to define biomarkers that can be used as diagnostic tools and patient stratification models for other conditions in which the interplay between genome, microbiome and metabolic profile has been suspected or proved. Finally, the project will collect biospecimens from a cohort of 600 infants as risk of ASD observed from birth, generating a unique biobank of 16,000 blood, stool, urine and saliva samples prospectively collected that can be exploited in future multiomic studies.

 Deliverables

List of deliverables.
OmnomicsNGS v2 release Demonstrators, pilots, prototypes 2020-04-25 10:50:00
Genome, epigenome and immune function interplay summary of hypothesis Documents, reports 2020-04-25 10:50:00
Pre-clinical study ethical approval report Documents, reports 2020-04-25 10:50:00
Updated state of the art report Documents, reports 2020-04-25 10:50:00
Microbiome, metabolome and immune function interplay summary of hypothesis Documents, reports 2020-04-25 10:50:00
Pre-clinical study 3/1 report Documents, reports 2020-04-25 10:50:00
External project website Websites, patent fillings, videos etc. 2020-04-25 10:50:00
Final clinical protocols Documents, reports 2020-04-25 10:50:00
Open data management plan Open Research Data Pilot 2020-04-25 10:50:00

Take a look to the deliverables list in detail:  detailed list of GEMMA deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Noemi Di Nanni, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, Ettore Mosca
Network-Based Integrative Analysis of Genomics, Epigenomics and Transcriptomics in Autism Spectrum Disorders
published pages: 3363, ISSN: 1422-0067, DOI: 10.3390/ijms20133363
International Journal of Molecular Sciences 20/13 2020-04-25
2019 Leonardo Emberti Gialloreti, Luigi Mazzone, Arianna Benvenuto, Alessio Fasano, Alicia Garcia Alcon, Aletta Kraneveld, Romina Moavero, Raanan Raz, Maria Pia Riccio, Martina Siracusano, Ditza A. Zachor, Marina Marini, Paolo Curatolo
Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations
published pages: 217, ISSN: 2077-0383, DOI: 10.3390/jcm8020217
Journal of Clinical Medicine 8/2 2020-04-25

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The information about "GEMMA" are provided by the European Opendata Portal: CORDIS opendata.

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