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UNBRACE TERMINATED

Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UNBRACE project word cloud

Explore the words cloud of the UNBRACE project. It provides you a very rough idea of what is the project "UNBRACE" about.

biology    subgroup    unfolded    upr    researcher    poor    colorectal    transfer    endoplasmic    er    crc    treatment    mapki    predictive    trial    stress    adopts    organoids    heel    models    braf    opportunity    achilles    xenograft    underpin    vulnerable    brafmt    form    cells    host    preliminary    reticulum    skills    protein    disturbances    solution    xenografts    stratified    fellowship    combined    training    proteins    attract    medicine    mek1    scientists    lab    onc201    excellent    academia    leader    survival    3d    hit    disciplines    prognostic    industry    pathology    receive    internationally    vitro    15    mt    syngeneic    brafi    strategy    patient    mobility    collaborative    outcome    activator    basis    machinery    vivo    ing    experimental    combination    network    datasets    effect    worst    give    strategies    sectors    molecular    accounts    mutant    unbrace    2i    clinical    urgent    ultimately    data    cancer    personalized    shown   

Project "UNBRACE" data sheet

The following table provides information about the project.

Coordinator
CELL STRESS DISCOVERIES LIMITED 

Organization address
address: UNIT 204, NUIG BUSINESS INNOVATION CENTRE, NEWCASTLE ROAD
city: GALWAY
postcode: n.a.
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CELL STRESS DISCOVERIES LIMITED IE (GALWAY) coordinator 187˙866.00

Map

 Project objective

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival. There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC.

Specific objectives of the proposal are 1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro. 2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models. 3. Assess prognostic/predictive role of ER stress proteins in CRC.

UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting BRAFMT CRC.

This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine.

The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial in BRAFMT CRC. The fellowship can form the basis to attract other scientists internationally, from other disciplines and sectors to receive training in these unique R&I skills.

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The information about "UNBRACE" are provided by the European Opendata Portal: CORDIS opendata.

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