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Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer

Total Cost €


EC-Contrib. €






 UNBRACE project word cloud

Explore the words cloud of the UNBRACE project. It provides you a very rough idea of what is the project "UNBRACE" about.

brafmt    biology    opportunity    prognostic    crc    lab    effect    survival    vitro    worst    attract    shown    disturbances    treatment    er    reticulum    organoids    proteins    ing    trial    leader    training    hit    ultimately    solution    urgent    strategies    braf    subgroup    network    receive    personalized    underpin    syngeneic    unbrace    activator    colorectal    cancer    mutant    mapki    adopts    collaborative    disciplines    vulnerable    15    basis    predictive    cells    scientists    strategy    endoplasmic    poor    give    academia    stress    mek1    form    vivo    achilles    accounts    industry    pathology    xenografts    experimental    models    researcher    3d    clinical    xenograft    protein    upr    internationally    datasets    combination    transfer    heel    host    onc201    data    mt    stratified    combined    2i    patient    preliminary    machinery    skills    brafi    fellowship    outcome    mobility    molecular    excellent    sectors    unfolded    medicine   

Project "UNBRACE" data sheet

The following table provides information about the project.


Organization address
city: GALWAY
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website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival. There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC.

Specific objectives of the proposal are 1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro. 2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models. 3. Assess prognostic/predictive role of ER stress proteins in CRC.

UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting BRAFMT CRC.

This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine.

The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial in BRAFMT CRC. The fellowship can form the basis to attract other scientists internationally, from other disciplines and sectors to receive training in these unique R&I skills.

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The information about "UNBRACE" are provided by the European Opendata Portal: CORDIS opendata.

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