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Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer

Total Cost €


EC-Contrib. €






 UNBRACE project word cloud

Explore the words cloud of the UNBRACE project. It provides you a very rough idea of what is the project "UNBRACE" about.

er    heel    brafi    braf    combination    organoids    upr    combined    3d    unfolded    worst    patient    trial    colorectal    academia    basis    receive    network    pathology    xenograft    vitro    cells    give    mek1    experimental    disturbances    survival    medicine    biology    machinery    adopts    subgroup    fellowship    skills    activator    xenografts    brafmt    form    training    protein    internationally    vulnerable    syngeneic    treatment    outcome    unbrace    ultimately    crc    mapki    clinical    urgent    transfer    shown    leader    onc201    hit    mobility    disciplines    lab    datasets    excellent    researcher    accounts    ing    preliminary    underpin    2i    stratified    predictive    models    endoplasmic    poor    strategies    collaborative    industry    reticulum    prognostic    cancer    scientists    15    effect    mt    data    stress    mutant    solution    vivo    molecular    host    personalized    strategy    proteins    achilles    sectors    attract    opportunity   

Project "UNBRACE" data sheet

The following table provides information about the project.


Organization address
city: GALWAY
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website: n.a.

contact info
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surname: n.a.
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email: n.a.
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 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival. There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC.

Specific objectives of the proposal are 1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro. 2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models. 3. Assess prognostic/predictive role of ER stress proteins in CRC.

UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting BRAFMT CRC.

This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine.

The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial in BRAFMT CRC. The fellowship can form the basis to attract other scientists internationally, from other disciplines and sectors to receive training in these unique R&I skills.

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The information about "UNBRACE" are provided by the European Opendata Portal: CORDIS opendata.

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