Opendata, web and dolomites

UNBRACE TERMINATED

Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 UNBRACE project word cloud

Explore the words cloud of the UNBRACE project. It provides you a very rough idea of what is the project "UNBRACE" about.

host    syngeneic    vivo    unfolded    strategy    xenografts    form    survival    er    unbrace    receive    ing    effect    basis    mobility    trial    datasets    organoids    sectors    protein    mek1    outcome    achilles    brafmt    excellent    subgroup    clinical    adopts    biology    colorectal    treatment    fellowship    opportunity    urgent    mapki    activator    shown    collaborative    strategies    academia    scientists    stratified    hit    training    molecular    personalized    combined    medicine    heel    poor    transfer    upr    accounts    vulnerable    ultimately    lab    experimental    15    internationally    give    skills    predictive    disturbances    stress    cells    onc201    xenograft    2i    patient    models    mt    industry    disciplines    machinery    network    preliminary    brafi    cancer    endoplasmic    vitro    crc    pathology    data    reticulum    braf    mutant    underpin    solution    proteins    leader    3d    combination    worst    researcher    prognostic    attract   

Project "UNBRACE" data sheet

The following table provides information about the project.

Coordinator
CELL STRESS DISCOVERIES LIMITED 

Organization address
address: UNIT 204, NUIG BUSINESS INNOVATION CENTRE, NEWCASTLE ROAD
city: GALWAY
postcode: n.a.
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CELL STRESS DISCOVERIES LIMITED IE (GALWAY) coordinator 187˙866.00

Map

 Project objective

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival. There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC.

Specific objectives of the proposal are 1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro. 2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models. 3. Assess prognostic/predictive role of ER stress proteins in CRC.

UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting BRAFMT CRC.

This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine.

The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial in BRAFMT CRC. The fellowship can form the basis to attract other scientists internationally, from other disciplines and sectors to receive training in these unique R&I skills.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "UNBRACE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "UNBRACE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More