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V.A. Cure SIGNED

A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies

Total Cost €

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EC-Contrib. €

0

Partnership

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 V.A. Cure project word cloud

Explore the words cloud of the V.A. Cure project. It provides you a very rough idea of what is the project "V.A. Cure" about.

cell    assembled    composition    pain    initiation    leaders    world    dysfunction    live    plethora    cutting    aberrant    deletion    biotech    genes    mosaic    companies    blood    outside    vitro    lacking    interaction    academic    editing    clinical    molecular    sheet    treatments    medical    gained    sudden    function    diseases    intersectoral    models    drug    vessel    vivo    close    maintenance    single    treatment    display    outreach    imaging    anomalies    lymph    endothelial    group    crispr    patients    identification    positions    dissection    graduates    genome    14    causing    inducible    laboratories    media    competitive    network    edge    communication    pharma    sequencing    highest    esrs    trained    light    candidates    leveraging    strategies    phage    cure    chronic    combination    industry    technologies    guarantee    perception    rna    ipscs    confocal    tissular    therapeutic    animal    training    secondments    rare    academia    generation    core    vascular    mechanisms    microfluidics    pathophysiological    presentation    multiphoton    vas    unmet    disabilities    uncovering    cas    establishing    death    writing    disease    seq   

Project "V.A. Cure" data sheet

The following table provides information about the project.

Coordinator
DE DUVE INSTITUTE 

Organization address
address: AVENUE HIPPOCRATE 75
city: BRUXELLES
postcode: 1200
website: www.deduveinstitute.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 3˙792˙135 €
 EC max contribution 3˙792˙135 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DE DUVE INSTITUTE BE (BRUXELLES) coordinator 512˙640.00
2    ASTRAZENECA AB SE (SODERTAELJE) participant 563˙965.00
3    UPPSALA UNIVERSITET SE (UPPSALA) participant 563˙965.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 549˙604.00
5    UNIVERSITAET POTSDAM DE (POTSDAM) participant 505˙576.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 281˙982.00
7    OULUN YLIOPISTO FI (OULU) participant 280˙805.00
8 SINGH PRATEEK FI participant 280˙805.00
9    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 252˙788.00
10    TAMPEREEN YLIOPISTO FI (TAMPERE) participant 0.00
11    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) partner 0.00
12    BELGIAN VASCULAR ANOMALY PATIENT ASSOCIATION BE (KRAAINEM) partner 0.00
13    CLINIQUES UNIVERSITAIRES SAINT-LUC BE (BRUXELLES) partner 0.00
14    LLS ROWIAK LASERLABSOLUTIONS GMBH DE (HANNOVER) partner 0.00
15    MOLECULINK AB SE (UPPSALA) partner 0.00
16    Perimed AB SE (Järfälla) partner 0.00
17    Sysmex Inostics GmbH DE (Hamburg) partner 0.00
18    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) partner 0.00

Map

 Project objective

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs. V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases. The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

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The information about "V.A. CURE" are provided by the European Opendata Portal: CORDIS opendata.

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