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V.A. Cure SIGNED

A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies

Total Cost €

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EC-Contrib. €

0

Partnership

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 V.A. Cure project word cloud

Explore the words cloud of the V.A. Cure project. It provides you a very rough idea of what is the project "V.A. Cure" about.

anomalies    tissular    endothelial    cas    pathophysiological    multiphoton    cutting    phage    ipscs    perception    blood    diseases    media    disease    light    sheet    pain    aberrant    treatment    genes    rna    cure    presentation    candidates    close    composition    disabilities    vivo    industry    mechanisms    function    14    vitro    outside    academic    generation    patients    plethora    cell    network    highest    maintenance    competitive    laboratories    medical    live    training    imaging    strategies    intersectoral    pharma    writing    clinical    gained    crispr    sudden    companies    leveraging    world    vas    guarantee    models    uncovering    graduates    edge    confocal    identification    causing    single    deletion    animal    chronic    lymph    microfluidics    inducible    outreach    vascular    rare    seq    positions    leaders    display    technologies    establishing    treatments    assembled    trained    dysfunction    editing    genome    lacking    group    dissection    drug    biotech    core    communication    academia    mosaic    therapeutic    interaction    molecular    vessel    esrs    sequencing    secondments    unmet    combination    initiation    death   

Project "V.A. Cure" data sheet

The following table provides information about the project.

Coordinator
DE DUVE INSTITUTE 

Organization address
address: AVENUE HIPPOCRATE 75
city: BRUXELLES
postcode: 1200
website: www.deduveinstitute.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 3˙792˙135 €
 EC max contribution 3˙792˙135 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DE DUVE INSTITUTE BE (BRUXELLES) coordinator 512˙640.00
2    ASTRAZENECA AB SE (SODERTAELJE) participant 563˙965.00
3    UPPSALA UNIVERSITET SE (UPPSALA) participant 563˙965.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 549˙604.00
5    UNIVERSITAET POTSDAM DE (POTSDAM) participant 505˙576.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 281˙982.00
7    OULUN YLIOPISTO FI (OULU) participant 280˙805.00
8 SINGH PRATEEK FI participant 280˙805.00
9    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 252˙788.00
10    TAMPEREEN YLIOPISTO FI (TAMPERE) participant 0.00
11    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) partner 0.00
12    BELGIAN VASCULAR ANOMALY PATIENT ASSOCIATION BE (KRAAINEM) partner 0.00
13    CLINIQUES UNIVERSITAIRES SAINT-LUC BE (BRUXELLES) partner 0.00
14    LLS ROWIAK LASERLABSOLUTIONS GMBH DE (HANNOVER) partner 0.00
15    MOLECULINK AB SE (UPPSALA) partner 0.00
16    Perimed AB SE (Järfälla) partner 0.00
17    Sysmex Inostics GmbH DE (Hamburg) partner 0.00
18    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) partner 0.00

Map

 Project objective

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs. V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases. The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

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The information about "V.A. CURE" are provided by the European Opendata Portal: CORDIS opendata.

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