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WHILYAS

Wound healing ILYA-style

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 WHILYAS project word cloud

Explore the words cloud of the WHILYAS project. It provides you a very rough idea of what is the project "WHILYAS" about.

spend    dried    acid    cagr    bacteria    heal    designed    eur    alarming    immunophysiology    countries    ulcers    million    cxcl12    accelerate    overuse    30    diabetic    swedish    difficulties    dfus    ilya100tm    mechanical    mortality    segment    66    budget    foot    2014    cheaper    unmet    drug    market    dressings    annual    healthcare    act    cancers    stems    rate    alone    implying    topical    4    lactobacillus    treatment    translates    revived    world    prior    manner    chronic    billion    limb    genetically    small    regeneration    healed    freeze    approx    patients    bioreactors    ev100    lactic    chosen    endogenously    amputation    savings    drugs    faster    quality    proteins    people    group    human    possibly    wound    diabetes    medical    delivered    efficiency    least    microbiology    antibiotics    2011    chemokine    library    therapeutic    first    limited    15    substantial    personal    social    life    modified    wounds    uppsala    care    site    11    administration    18    tissue    water    debridement    candidate    sciences    innovation    agricultural    industrialized    healing    local    tackling    university    expressing    total    complications   

Project "WHILYAS" data sheet

The following table provides information about the project.

Coordinator		 ILYA PHARMA AB 

Organization address
address: DAG HAMMARSKIOLDS VAG 30
city: UPPSALA
postcode: 752 37
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Project website http://www.ilyapharma.se
 Total cost 2˙992˙575 €
 EC max contribution 2˙992˙575 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ILYA PHARMA AB SE (UPPSALA) coordinator 2˙992˙575.00

Map

 Project objective

The objective of the project is to develop the EV100 drug candidate to heal chronic wounds in patients with diabetes in a better, faster, and cheaper manner than any method available today. We have chosen to target wounds in patients with diabetes, due to a large unmet medical need in this group. Today, 18% of people with diabetes have a chronic wound which translates into at least 6 million people in Europe alone. One of the complications of diabetes, diabetic foot ulcers (DFUs) often result in limb amputation. The mortality rate after an amputation is 30% within the first year, which is similar to several cancers. Even more alarming, treatment is today limited to mechanical debridement, use of different dressings, and a substantial overuse of antibiotics. Industrialized countries spend 2-4% of total healthcare budget on chronic wounds. The market for wound care is EUR 15 billion and the segment of DFUs is in the range of EUR 1.5 billion, with 11% CAGR 2011-2014. We have designed and built genetically modified lactic acid bacteria that accelerate wound healing with a unique efficiency. Human therapeutic proteins endogenously involved in tissue regeneration are continuously delivered on site in wounds by the lactic acid bacteria that act like small local bioreactors. EV100 is one of the candidate drugs in our library using Ilya100TM technology and is Lactobacillus expressing the human chemokine CXCL12. The Lactobacillus are freeze-dried and revived with water just prior to topical administration. The innovation stems from world-leading medical research in immunophysiology and microbiology at Uppsala University and the Swedish University of Agricultural Sciences. With EV100 chronic wounds could possibly be healed approx. 66% faster, implying annual cost savings of EUR 6 billion in the US and Europe and tackling all the personal and social difficulties associated with chronic wounds, increasing the quality of life of patients all around the world.

 Deliverables

List of deliverables.
An updated plan for the exploitation and dissemination of the results Documents, reports 2020-02-11 12:59:43
ORDP - Open Research Data Pilot Open Research Data Pilot 2020-02-11 12:59:43

Take a look to the deliverables list in detail:  detailed list of WHILYAS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Evelina Vågesjö, Emelie Öhnstedt, Anneleen Mortier, Hava Lofton, Fredrik Huss, Paul Proost, Stefan Roos, Mia Phillipson
Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria
published pages: 1895-1900, ISSN: 0027-8424, DOI: 10.1073/pnas.1716580115 		Proceedings of the National Academy of Sciences 115/8 2020-02-11
2019 Emelie Öhnstedt, Hava Lofton Tomenius, Evelina Vågesjö, Mia Phillipson
The discovery and development of topical medicines forwound healing
published pages: , ISSN: 1746-045X, DOI: 		Expert Opinion on Drug Discovery 2020-02-11

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The information about "WHILYAS" are provided by the European Opendata Portal: CORDIS opendata.

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