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VITAE SIGNED

VIrTual BrAin PErfusion: Assessing cerebrovascular function by High Performance Computing from 3D brain vessel network data for vascular-targeted drug development in neurodegenerative diseases.

Total Cost €

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EC-Contrib. €

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Partnership

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 VITAE project word cloud

Explore the words cloud of the VITAE project. It provides you a very rough idea of what is the project "VITAE" about.

vitae    function    performances    stages    environments    tremendously    neurodegenerative    standards    poc    outputs    capacities    local    software    accelerate    versions    vascular    brain    mouse    ad    neurotoxic    measurable    data    upgrade    computing    consolidator    anatomical    strategy    create    nor    vessel    industry    modifying    erc    centers    diseases    discovery    metabolic    flow    interface    explore    vitae4wholebrain    quantitative    strategies    conduced    ipr    therapeutic    networks    becomes    partnership    market    programming    player    documentation    platform    decreases    with    opens    waste    possibilities    central    deposits    position    performance    cognitive    idea    optimize    service    licensing    drug    epidemiologic    tau    alzheimer    meeting    statistical    nutrient    removal    deficits    versatile    parallel    accessed    specifications    blood    sense    computational    cerebrovascular    accumulation    minimal    disease    network    symptomatic    modeling    skills    programing    competitors    partnering    hpc    industrial    brainmicroflow    amyloid   

Project "VITAE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 149˙738 €
 EC max contribution 149˙738 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 149˙738.00

Map

 Project objective

With the recent discovery that brain blood flow decreases — in a statistical and epidemiologic sense — before accumulation of neurotoxic deposits (e.g. amyloid and tau) and before any measurable cognitive deficits, the brain vascular system is increasingly recognized as a key player in the development of Alzheimer’s Disease (AD). This opens the way for the development of new disease-modifying therapeutic strategies targeting vascular pathways at early stages of AD, i.e. long before the neurodegenerative process becomes established and symptomatic. The central idea of this POC proposal is that High Performance Computing (HPC) assessment of cerebrovascular function from quantitative vessel network data will tremendously accelerate vascular-targeted drug development for neurodegenerative brain diseases. One of the key outputs of the research conduced in the ERC Consolidator BrainMicroFlow is indeed a HPC platform for modeling blood flow, nutrient delivery and metabolic waste removal in large anatomical vessel networks of the brain. However, using this platform requires advanced and specific parallel programing skills, which are in general not available, neither in the research nor in the R&D industrial environments focused on Alzheimer Disease. Thus, our aims are 1/ to upgrade the technical specifications of this platform and to develop a user-friendly and versatile interface, documentation and support, to create a new software, called VITAE, meeting the industry standards, that users with minimal programming skills could use on their own or local computational resources; 2/ to optimize the HPC capacities of VITAE so that its performances can reach the scale of a whole mouse brain (VITAE4WholeBrain), that could be accessed as a service provided to end users by partnering computational centers; 3/ to assess the market and the competitors for both versions of VITAE; 4/ to determine IPR position and strategy, and 5/ to explore licensing and partnership possibilities.

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The information about "VITAE" are provided by the European Opendata Portal: CORDIS opendata.

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