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VITAE SIGNED

VIrTual BrAin PErfusion: Assessing cerebrovascular function by High Performance Computing from 3D brain vessel network data for vascular-targeted drug development in neurodegenerative diseases.

Total Cost €

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EC-Contrib. €

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Partnership

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 VITAE project word cloud

Explore the words cloud of the VITAE project. It provides you a very rough idea of what is the project "VITAE" about.

programing    nor    metabolic    with    meeting    environments    function    conduced    alzheimer    partnership    brainmicroflow    vessel    tremendously    industrial    versions    service    epidemiologic    blood    performance    interface    vascular    computing    programming    quantitative    becomes    skills    brain    strategy    symptomatic    accelerate    statistical    software    networks    modeling    standards    create    nutrient    competitors    flow    versatile    outputs    computational    position    disease    centers    measurable    cerebrovascular    drug    data    ipr    market    central    upgrade    performances    vitae4wholebrain    explore    network    deposits    idea    deficits    decreases    therapeutic    strategies    tau    partnering    accumulation    cognitive    industry    anatomical    opens    ad    possibilities    platform    optimize    consolidator    erc    modifying    sense    parallel    neurodegenerative    neurotoxic    stages    documentation    removal    specifications    amyloid    licensing    diseases    minimal    hpc    local    discovery    accessed    capacities    poc    mouse    vitae    player    waste   

Project "VITAE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 149˙738 €
 EC max contribution 149˙738 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 149˙738.00

Map

 Project objective

With the recent discovery that brain blood flow decreases — in a statistical and epidemiologic sense — before accumulation of neurotoxic deposits (e.g. amyloid and tau) and before any measurable cognitive deficits, the brain vascular system is increasingly recognized as a key player in the development of Alzheimer’s Disease (AD). This opens the way for the development of new disease-modifying therapeutic strategies targeting vascular pathways at early stages of AD, i.e. long before the neurodegenerative process becomes established and symptomatic. The central idea of this POC proposal is that High Performance Computing (HPC) assessment of cerebrovascular function from quantitative vessel network data will tremendously accelerate vascular-targeted drug development for neurodegenerative brain diseases. One of the key outputs of the research conduced in the ERC Consolidator BrainMicroFlow is indeed a HPC platform for modeling blood flow, nutrient delivery and metabolic waste removal in large anatomical vessel networks of the brain. However, using this platform requires advanced and specific parallel programing skills, which are in general not available, neither in the research nor in the R&D industrial environments focused on Alzheimer Disease. Thus, our aims are 1/ to upgrade the technical specifications of this platform and to develop a user-friendly and versatile interface, documentation and support, to create a new software, called VITAE, meeting the industry standards, that users with minimal programming skills could use on their own or local computational resources; 2/ to optimize the HPC capacities of VITAE so that its performances can reach the scale of a whole mouse brain (VITAE4WholeBrain), that could be accessed as a service provided to end users by partnering computational centers; 3/ to assess the market and the competitors for both versions of VITAE; 4/ to determine IPR position and strategy, and 5/ to explore licensing and partnership possibilities.

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The information about "VITAE" are provided by the European Opendata Portal: CORDIS opendata.

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