CULPRIT-SHOCK

Multivessel versus culprit lesion only percutaneous revascularization in patients with acute myocardial infarction complicated by cardiogenic shock

 Coordinatore UNIVERSITAET ZU LUEBECK 

 Organization address address: RATZEBURGER ALLEE 160
city: LUEBECK
postcode: 23538

contact info
Titolo: Mrs.
Nome: Christina
Cognome: Catana-Hoppe
Email: send email
Telefono: 494515000000
Fax: 494515000000

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.culprit-shock.eu
 Totale costo 7˙803˙369 €
 EC contributo 5˙999˙145 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2017-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET ZU LUEBECK

 Organization address address: RATZEBURGER ALLEE 160
city: LUEBECK
postcode: 23538

contact info
Titolo: Mrs.
Nome: Christina
Cognome: Catana-Hoppe
Email: send email
Telefono: 494515000000
Fax: 494515000000

DE (LUEBECK) coordinator 1˙818˙072.00
2    STIFTUNG INSTITUT FUR HERZINFARKTFORSCHUNG LUDWIGSHAFEN

 Organization address address: BREMSERSTRASSE 79
city: LUDWIGSHAFEN
postcode: 67063

contact info
Titolo: Mr.
Nome: Marco
Cognome: Dech
Email: send email
Telefono: +49 6215032834
Fax: +49 6215032855

DE (LUDWIGSHAFEN) participant 837˙720.00
3    A.C.T.I.O.N ALLIES IN CARDIOVASCULAR TRIALS INITIATIVES AND ORGANIZEDNETWORKS ASSOCIATION

 Organization address address: BOULEVARD DE L HOPITAL 47
city: PARIS
postcode: 75013

contact info
Titolo: Ms.
Nome: Vanessa
Cognome: Gallois
Email: send email
Telefono: +33 142162959
Fax: +33 142162931

FR (PARIS) participant 599˙580.00
4    UNIVERSITAET LEIPZIG

 Organization address address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109

contact info
Titolo: Prof.
Nome: Joachim
Cognome: Thiery
Email: send email
Telefono: 493420000000

DE (LEIPZIG) participant 512˙439.00
5    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Mrs.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: +49 8928810414
Fax: +49 8928810420

DE (MUENCHEN) participant 394˙420.00
6    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mr.
Nome: Edwin
Cognome: Groenewegen Van Wijk
Email: send email
Telefono: +31 205660075

NL (AMSTERDAM) participant 384˙720.00
7    UNIVERSITY OF GLASGOW

 Organization address address: University Avenue
city: GLASGOW
postcode: G12 8QQ

contact info
Titolo: Mr.
Nome: Joe
Cognome: Galloway
Email: send email
Telefono: 441413000000
Fax: 441413000000

UK (GLASGOW) participant 227˙045.00
8    HERZZENTRUM LEIPZIG GMBH

 Organization address address: STRUEMPELLSTRASSE 39
city: LEIPZIG
postcode: 4289

contact info
Titolo: Ms.
Nome: Simone
Cognome: Bläser
Email: send email
Telefono: +49 3418651433
Fax: +49 3418651461

DE (LEIPZIG) participant 212˙100.00
9    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Ms.
Nome: Alix
Cognome: Pillot
Email: send email
Telefono: 33140274613

FR (PARIS) participant 195˙900.00
10    NATIONAL WAITING TIMES CENTRE BOARD

 Organization address address: BEARDMORE STREET CLYDEBANK
city: GLASGOW
postcode: G81 4HX

contact info
Titolo: Dr.
Nome: Catherine
Cognome: Sinclair
Email: send email
Telefono: +44141 951 5440

UK (GLASGOW) participant 189˙719.00
11    INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

 Organization address address: ul. Alpejska 42
city: WARSZAWA
postcode: 4628

contact info
Titolo: Mr.
Nome: Marek
Cognome: Banaszewski
Email: send email
Telefono: +48 223434314
Fax: +48 228154267

PL (WARSZAWA) participant 138˙600.00
12    INSELSPITAL-STIFTUNG

 Organization address address: FREIBURGSTRASSE 18
city: BERN
postcode: 3010

contact info
Titolo: Prof.
Nome: Stephan
Cognome: Windecker
Email: send email
Telefono: +41 31 6324497

CH (BERN) participant 105˙750.00
13    UNIVERSITAIR ZIEKENHUIS ANTWERPEN

 Organization address address: WILRIJKSTRAAT 10
city: EDEGEM
postcode: 2650

contact info
Titolo: Prof.
Nome: Christiaan
Cognome: Vrints
Email: send email
Telefono: +32 3 821 35 29

BE (EDEGEM) participant 85˙000.00
14    ARCISPEDALE SANTA MARIA NUOVA AZIENDA OSPEDALIERA

 Organization address address: VIALE UMBERTO I 50
city: REGGIO EMILIA
postcode: 42100

contact info
Titolo: Dr.
Nome: Teresa
Cognome: Coppola
Email: send email
Telefono: +39 0522296212
Fax: +39 0522295561

IT (REGGIO EMILIA) participant 80˙280.00
15    VIESOJI ISTAIGA VILNIAUS UNIVERSITETO LIGONINES SANTARISKIU KLINIKOS

 Organization address address: SANTARISKIU G 2
city: VILNIUS
postcode: 8661

contact info
Titolo: Ms.
Nome: Liuda
Cognome: Grigentiene
Email: send email
Telefono: 3702365007
Fax: +370 5236 5111

LT (VILNIUS) participant 75˙720.00
16    UNIVERZITETNI KLINICNI CENTER LJUBLJANA

 Organization address address: ZALOSKA CESTA 002
city: LJUBLJANA
postcode: 1000

contact info
Titolo: Mr.
Nome: Miha
Cognome: Zemlja
Email: send email
Telefono: +386 15222191
Fax: +386 15221234

SI (LJUBLJANA) participant 72˙000.00
17    VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN

 Organization address address: Montleartstrasse 37
city: WIEN
postcode: 1160

contact info
Titolo: Ms.
Nome: Andrea
Cognome: Prusse
Email: send email
Telefono: 431492000000
Fax: +43 491502309

AT (WIEN) participant 45˙960.00
18    AZIENDA OSPEDALIERA DELLA PROVINCIA DI LECCO

 Organization address address: VIA DELL'EREMO 9/11
city: LECCO
postcode: 23900

contact info
Titolo: Dr.
Nome: Micol
Cognome: Bernardi
Email: send email
Telefono: 390341000000

IT (LECCO) participant 24˙120.00
19    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Dr.
Nome: Johan
Cognome: Sundelin
Email: send email
Telefono: 46186119312

SE (UPPSALA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

acutely    shock    ami    cs    disease    patients    lesion    randomized    renal    culprit    multivessel    complicated    coronary    pci    data    cardiogenic    percutaneous    registry    mortality    model    lesions   

 Obiettivo del progetto (Objective)

'Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. The clinician is faced with the decision to either 1) intervene only on the culprit lesion acutely responsible for the initiation of cardiogenic shock, or 2) treat additional lesions considered hemodynamically significant but not acutely triggering the CS cascade as well. Current guidelines recommend percutaneous coronary intervention of all critical lesions. However, due to a lack of randomized trials, these recommendations are solely based on registry data and pathophysiological considerations. Aim of the randomized CULPRIT-SHOCK trial is therefore to compare a) immediate multivessel PCI versus b) culprit lesion only PCI in patients with AMI complicated by CS. A total of 706 CS patients will be randomized in several European countries. The primary endpoint will be 30-day all-cause mortality and/or severe renal failure requiring renal replacement therapy. CULPRIT-SHOCK will therefore determine the optimal percutaneous revascularization strategy in patients with AMI and multivessel disease complicated by CS. In addition, a comprehensive array of efficacy, safety and socio-economic parameters for the chosen population will be assessed. Multiple secondary endpoints and several substudies (microcirculation, biomarkers, angiography) will serve to further understand the presumed differential effects of the 2 treatment arms and to understand the underlying pathophysiology and prognostic markers. From these parameters a multivariable regression model and a risk score for the prediction of clinical prognosis and a cost-effectiveness model in AMI and CS will be developed. Furthermore, CULPRIT-SHOCK will obtain data on CS patients not meeting inclusion criteria by instituting a separate registry.'

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