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HAZARDOmics SIGNED

Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment

Total Cost €

EC-Contrib. €

Partnership

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HAZARDOmics project word cloud

Explore the words cloud of the HAZARDOmics project. It provides you a very rough idea of what is the project "HAZARDOmics" about.

metabolomics prevention metabolic hydrophilic first ground complete action innovative analytical purposes bpa consequently nowadays broad risk bisphenol hazardomics community exposure health resolution intended public employed discovery moa obtain liquid fingerprint mobility biomarkers disruptor endocrine profiling society cocktail civil breaking perspective effect electrophoresis samples ce mass priorities technique connection techniques im hrms compounds exposures capillary mechanisms strategy risks bisphenyls separation lc ion strategies edcs diseases sense framework emerged enforcement time interaction hilic polychlorinated chemical chemicals chronic involve complementary boundaries rp human understand blood extended additional reverse spectrometry modes doses possibility serum arising chromatography workflow pcbs

Project "HAZARDOmics" data sheet

The following table provides information about the project.

Coordinator	ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE Organization address address: Site de la Chantrerie, Route de Gachet city: NANTES postcode: 44307 website: www.oniris-nantes.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE Organization address address: Site de la Chantrerie, Route de Gachet city: NANTES postcode: 44307 website: www.oniris-nantes.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NANTES)	coordinator	185˙076.00

Map

Project objective

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

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The information about "HAZARDOMICS" are provided by the European Opendata Portal: CORDIS opendata.