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HAZARDOmics SIGNED

Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment

Total Cost €

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EC-Contrib. €

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Partnership

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 HAZARDOmics project word cloud

Explore the words cloud of the HAZARDOmics project. It provides you a very rough idea of what is the project "HAZARDOmics" about.

fingerprint    innovative    samples    moa    chronic    cocktail    effect    reverse    complementary    profiling    risks    strategy    strategies    breaking    understand    chemical    separation    bisphenyls    chemicals    risk    arising    liquid    metabolic    pcbs    ground    bpa    resolution    biomarkers    mobility    ion    involve    workflow    disruptor    time    electrophoresis    serum    sense    edcs    first    polychlorinated    broad    diseases    compounds    hilic    enforcement    technique    mass    metabolomics    modes    society    connection    exposure    prevention    mechanisms    ce    purposes    human    chromatography    framework    analytical    community    doses    health    exposures    capillary    additional    public    obtain    action    hazardomics    hrms    blood    boundaries    discovery    extended    hydrophilic    im    emerged    rp    complete    interaction    intended    civil    techniques    priorities    consequently    endocrine    employed    possibility    lc    bisphenol    spectrometry    nowadays    perspective   

Project "HAZARDOmics" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE 

Organization address
address: Site de la Chantrerie, Route de Gachet
city: NANTES
postcode: 44307
website: www.oniris-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE FR (NANTES) coordinator 185˙076.00

Map

 Project objective

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

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The information about "HAZARDOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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