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HAZARDOmics SIGNED

Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment

Total Cost €

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EC-Contrib. €

0

Partnership

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 HAZARDOmics project word cloud

Explore the words cloud of the HAZARDOmics project. It provides you a very rough idea of what is the project "HAZARDOmics" about.

metabolomics    prevention    metabolic    hydrophilic    first    ground    complete    action    innovative    analytical    purposes    bpa    consequently    nowadays    broad    risk    bisphenol    hazardomics    community    exposure    health    resolution    intended    public    employed    discovery    moa    obtain    liquid    fingerprint    mobility    biomarkers    disruptor    endocrine    profiling    society    cocktail    civil    breaking    perspective    effect    electrophoresis    samples    ce    mass    priorities    technique    connection    techniques    im    hrms    compounds    exposures    capillary    mechanisms    strategy    risks    bisphenyls    separation    lc    ion    strategies    edcs    diseases    sense    framework    emerged    enforcement    time    interaction    hilic    polychlorinated    chemical    chemicals    chronic    involve    complementary    boundaries    rp    human    understand    blood    extended    additional    reverse    spectrometry    modes    doses    possibility    serum    arising    chromatography    workflow    pcbs   

Project "HAZARDOmics" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE 

Organization address
address: Site de la Chantrerie, Route de Gachet
city: NANTES
postcode: 44307
website: www.oniris-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE FR (NANTES) coordinator 185˙076.00

Map

 Project objective

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

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