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EDCMET SIGNED

Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "EDCMET" data sheet

The following table provides information about the project.

Coordinator
ITA-SUOMEN YLIOPISTO 

Organization address
address: YLIOPISTONRANTA 1 E
city: KUOPIO
postcode: 70211
website: www.uef.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 5˙980˙408 €
 EC max contribution 5˙980˙408 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 2˙065˙432.00
2    OULUN YLIOPISTO FI (OULU) participant 870˙193.00
3    BUNDESINSTITUT FUER RISIKOBEWERTUNG DE (BERLIN) participant 420˙000.00
4    UNIVERSITY OF LEEDS UK (LEEDS) participant 401˙031.00
5    PAMGENE INTERNATIONAL BV NL (DEN HAAG) participant 398˙000.00
6    WAGENINGEN UNIVERSITY NL (WAGENINGEN) participant 370˙000.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 360˙050.00
8    EUROSAFE FR (SANT-GREGOIRE) participant 299˙187.00
9    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) participant 280˙003.00
10    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 276˙510.00
11    UNIVERZITA KARLOVA CZ (PRAHA 1) participant 240˙000.00

Map

 Project objective

Endocrine disruptors (EDs) are defined as exogenous chemicals that alter functions of the endocrine system, thereby causing adverse health effects in an organism or its progeny. Historically, the field of ED research has focused on reproductive endocrinology and related hormones, which is reflected in the regulatory test methods assessing endocrine effects of xenobiotics. However, recent evidence links increased incidence of metabolic syndrome (a cluster of metabolic risk factors including abdominal obesity, dyslipidemia, elevated blood pressure, and elevated fasting glucose) to EDs, increasing the incidence of atherosclerosis and type 2 diabetes. Despite these findings, adequate testing methods for metabolic effects of EDs are lacking. The project “Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways” (EDCMET) brings together experts in various research fields, including systems toxicologists, experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills and ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. This proposal focuses on developing novel test methods and models to assess the metabolic effects of EDs. Combined in silico methods, in vitro and in vivo methods are developed with an emphasis on liver and adipose tissue and endocrine pathways related to their metabolism. In addition, epidemiological and field monitoring data is used to gain information regarding the exposure to chemicals and ED-related metabolic effects. The interdisciplinary approach and complementary expertise of the participants will identify novel mechanisms of action, and in collaboration with the European Commission Joint Research Centre (JRC) providing an interface between the programme and European regulatory agencies, novel validated test methods for regulatory purposes will be generated.

 Deliverables

List of deliverables.
Initial press release Websites, patent fillings, videos etc. 2020-03-06 19:02:44
Project website for internal access as well as for public access Websites, patent fillings, videos etc. 2020-03-06 19:02:44
Formation of External Scientific Advisory Board Documents, reports 2020-03-06 19:02:44
Data management plan Open Research Data Pilot 2020-03-06 19:02:44

Take a look to the deliverables list in detail:  detailed list of EDCMET deliverables.

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The information about "EDCMET" are provided by the European Opendata Portal: CORDIS opendata.

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