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DDRMac SIGNED

DNA Damage Response-instructed Macrophage Differentiation in Granulomatous Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DDRMac project word cloud

Explore the words cloud of the DDRMac project. It provides you a very rough idea of what is the project "DDRMac" about.

stress    macrophage    infection    inflammation    run    community    implications    replication    dysregulation    chronic    genotoxic    black    herrtwich    granuloma    unravelled    structures    programs    diseases    carry    2016    signatures    healthy    fundamental    cellular    millions    socioeconomic    maintaining    children    replace    link    box    remodelling    cancer    hallmark    dna    arthritis    diverse    modules    inflammatory    regulating    last    tend    signals    genetic    multinucleated    granulomatous    crossing    operate    context    pathologies    immunology    worldwide    outcome    activated    granulomas    regulator    precursors    biology    translated    largely    tremendous    adults    leads    array    techniques    burden    differentiation    block    reprogramming    promotes    unravel    immune    unexplored    intriguing    revealed    course    models    immunity    scientific    trigger    anticipated    tissues    ddr    human    macrophages    cell    therapeutic    tissue    molecular    hypothesize    young    damage    critical   

Project "DDRMac" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙500˙000.00

Map

 Project objective

Macrophage differentiation programs are critical for the outcome of immunity against infection, chronic inflammatory diseases and cancer. How diverse inflammatory signals are translated to macrophage programs in the large range of human pathologies is largely unexplored. In the last years we focused on macrophage differentiation in granulomatous diseases. These affect millions worldwide, including young adults and children and tend to run a chronic course, with a high socioeconomic burden. Their common hallmark is the formation of granulomas, macrophage-driven structures of organized inflammation that replace healthy tissue. We revealed that macrophage precursors in granulomas experience a replication block and trigger the DNA Damage Response (DDR), a fundamental cellular process activated in response to genotoxic stress. This leads to the formation of multinucleated macrophages with tissue-remodelling signatures (Herrtwich, Cell 2016). Our work unravelled an intriguing link between genotoxic stress and granuloma-specific macrophage programs. The molecular pathways regulating DDR-driven macrophage differentiation and their role in chronic inflammatory pathologies remain however a black box. We hypothesize that the DDR promotes macrophage reprogramming to inflammation-maintaining modules. Such programs operate in granulomatous diseases and in chronic arthritis. Using state-of-the art genetic models, human tissues and an array of techniques crossing the fields of immunology, cell biology and cancer biology, our goal is to unravel the macrophage-specific response to genotoxic stress as an essential regulator of chronic inflammation-induced pathologies. The anticipated results will provide the scientific community with new knowledge on the role of genotoxic stress in immune dysregulation and will carry tremendous implications for the therapeutic targeting of macrophages in the context of chronic inflammatory diseases and cancer.

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The information about "DDRMAC" are provided by the European Opendata Portal: CORDIS opendata.

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