EURENOMICS

European Consortium for High-Throughput Research in Rare Kidney Diseases

 Coordinatore UNIVERSITAETSKLINIKUM HEIDELBERG 

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: +49 6221 567086
Fax: +49 6221 565460

 Nazionalità Coordinatore Germany [DE]
 Totale costo 15˙820˙098 €
 EC contributo 11˙994˙567 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-1
 Funding Scheme CP-IP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: +49 6221 567086
Fax: +49 6221 565460

DE (HEIDELBERG) coordinator 980˙000.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mr.
Nome: Nicolas
Cognome: Jeanjean
Email: send email
Telefono: +33 1 40 78 49 01
Fax: +33 1 40 78 49 98

FR (PARIS) participant 1˙845˙713.00
3    Genomatix Software GmbH

 Organization address address: Bayerstrasse 85a
city: Muenchen
postcode: 80335

contact info
Titolo: Dr.
Nome: Korbinian
Cognome: Grote
Email: send email
Telefono: +49 89 599766 61
Fax: +49 89 599766 55

DE (Muenchen) participant 957˙000.00
4    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Olivier
Cognome: Devuyst
Email: send email
Telefono: +41 44 635 50 82
Fax: +41 44 635 68 14

CH (ZURICH) participant 850˙840.00
5    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

 Organization address address: Via Giuseppe La Masa 19
city: MILANO
postcode: 20156

contact info
Titolo: Ms.
Nome: Maria Grazia
Cognome: Pezzoni
Email: send email
Telefono: +39 02 39014304
Fax: +39 02 39009728

IT (MILANO) participant 650˙001.00
6    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Mr.
Nome: Wim
Cognome: Van Oijen
Email: send email
Telefono: +31 24 36 19419

NL (NIJMEGEN) participant 521˙691.00
7    METABOMETRIX LTD

 Organization address address: PRINCE CONSORT ROAD
city: LONDON
postcode: SW7 2BP

contact info
Titolo: Prof.
Nome: John
Cognome: Lindon
Email: send email
Telefono: +44 20 7594 3194
Fax: +44 20 7594 3066

UK (LONDON) participant 507˙000.00
8    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Mrs.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: +49 89 288 104 14
Fax: +49 89 288 104 20

DE (MUENCHEN) participant 450˙000.00
9    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Mr.
Nome: Joost
Cognome: Warsanis
Email: send email
Telefono: +31 88 7568064
Fax: +31 88 7553660

NL (UTRECHT) participant 444˙910.00
10    PHILOCHEM AG

 Organization address address: WOLFGANG PAULI STRASSE 10
city: ZURICH
postcode: 8093

contact info
Titolo: Dr.
Nome: Sarah
Cognome: Wulhfard
Email: send email
Telefono: +41 43 544 88 10
Fax: +41 43 544 88 09

CH (ZURICH) participant 440˙000.00
11    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Borg-Carbott
Cognome: Greta
Email: send email
Telefono: 442031000000
Fax: 442078000000

UK (LONDON) participant 424˙156.00
12    UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN

 Organization address address: SOUTH STREET 3003 1068
city: ANN ARBOR
postcode: 46109 1274

contact info
Titolo: Ms.
Nome: Christine
Cognome: Koch
Email: send email
Telefono: +1 734 764 7250
Fax: +1 734 764 4053

US (ANN ARBOR) participant 418˙198.00
13    COMPREHENSIVE BIOMARKER CENTER GMBH

 Organization address address: IM NEUENHEIMER FELD 519
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Markus
Cognome: Beier
Email: send email
Telefono: +49 6221 6510 380
Fax: +49 6221 6510 329

DE (HEIDELBERG) participant 410˙000.00
14    HACETTEPE UNIVERSITESI

 Organization address address: HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI
city: CANKAYA ANKARA
postcode: 6800

contact info
Titolo: Prof.
Nome: Fatih
Cognome: Ozaltin
Email: send email
Telefono: +90 312 305 2645
Fax: +90 312 309 4232

TR (CANKAYA ANKARA) participant 375˙000.00
15    MULTIPLICOM NV

 Organization address address: GALILEILAAN 18
city: NIEL
postcode: 2845

contact info
Titolo: Mr.
Nome: Luc
Cognome: Lammens
Email: send email
Telefono: +32 4995254524
Fax: +32 24017218

BE (NIEL) participant 351˙600.00
16    MOSAIQUES DIAGNOSTICS GMBH

 Organization address address: Mellendorfer Strasse 7-9
city: HANNOVER
postcode: 30625

contact info
Titolo: Dr.
Nome: Petra
Cognome: Zürbig
Email: send email
Telefono: +49 511 554744 15
Fax: +49 511 554744 31

DE (HANNOVER) participant 345˙000.00
17    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: André
Cognome: Brändli
Email: send email
Telefono: +49 89 2180 76531
Fax: +49 89 2180 76503

DE (MUENCHEN) participant 280˙000.00
18    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Dr.
Nome: Katherine
Cognome: Boylan
Email: send email
Telefono: +44 161 275 8796
Fax: +44 161 275 2445

UK (MANCHESTER) participant 249˙883.00
19    UNIVERSITY OF BRISTOL

 Organization address address: TYNDALL AVENUE SENATE HOUSE
city: BRISTOL
postcode: BS8 1TH

contact info
Titolo: Mrs.
Nome: Elodie
Cognome: Mahieu-Wedande
Email: send email
Telefono: +44 117 3318309

UK (BRISTOL) participant 249˙517.00
20    OULUN YLIOPISTO

 Organization address address: Pentti Kaiteran Katu 1
city: OULU
postcode: 90014

contact info
Titolo: Mr.
Nome: Arto
Cognome: Eljander
Email: send email
Telefono: +358 8 5534133
Fax: +358 8 5534170

FI (OULU) participant 234˙900.00
21    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Prof.
Nome: Alberto
Cognome: Sereno Alvarez
Email: send email
Telefono: +34 915668852
Fax: 34915668913

ES (MADRID) participant 200˙000.00
22    ACQUIFER AG

 Organization address address: SOPHIENSTRASSE 136
city: KARLSRUHE
postcode: 76135

contact info
Nome: Ralf
Cognome: Mulflur
Email: send email
Telefono: +49 7218308740
Fax: +49 72183087499

DE (KARLSRUHE) participant 157˙314.50
23    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS KNOELL INSTITUTE

 Organization address address: Beutenbergstrasse 11a
city: JENA
postcode: 7745

contact info
Titolo: Dr.
Nome: Michael
Cognome: Ramm
Email: send email
Telefono: +49 3641 5321011
Fax: +49 3641 5320801

DE (JENA) participant 150˙000.00
24    PHILOGEN SPA

 Organization address address: PIAZZA LA LIZZA 7
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Chiara
Cognome: Falciani
Email: send email
Telefono: +39 577 17816
Fax: +39 577 1781680

IT (SIENA) participant 149˙960.00
25    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Ms.
Nome: Alix
Cognome: Pillot
Email: send email
Telefono: 33140274613
Fax: 33144841788

FR (PARIS) participant 149˙640.00
26    UNIVERSITY OF NEWCASTLE UPON TYNE

 Organization address address: Kensington Terrace 6
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU

contact info
Titolo: Ms.
Nome: Aleona
Cognome: Blinova
Email: send email
Telefono: +44 191 2824528
Fax: +44 191 2824524

UK (NEWCASTLE UPON TYNE) participant 149˙592.00
27    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Sarah
Cognome: Malevé
Email: send email
Telefono: +32 16 3 20611
Fax: +32 16 3 26515

BE (LEUVEN) participant 49˙998.00
28    Karlsruher Institut fuer Technologie

 Organization address address: Kaiserstrasse 12
city: Karlsruhe
postcode: 76131

contact info
Titolo: Ms.
Nome: Natascha
Cognome: Kindsvogel
Email: send email
Telefono: +49 721 608 25414
Fax: +49 721 608 25403

DE (Karlsruhe) participant 2˙653.05

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

metabolome    morphological    biomarkers    genes    disease    description    screening    diagnostic    eurenomics    phenotypic    patient    proteome    data    amniotic    vivo    models    innovative    diseases    strategies    efficient    disorders    risk    mutations    sequencing    syndrome    clinical    therapeutic    prognosis    significant    progress    urine    genetic    fluids    technologies    life    biorepositories    body    dna    molecular    dependent    tissue    throughput    kidney    agents    fluid    integrate    rare    mechanisms    compound    patients    renal    combined    profiling    dismal    exome    prediction    signatures    vitro   

 Obiettivo del progetto (Objective)

'EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.'

Introduzione (Teaser)

European researchers are using high-throughput technologies to delineate the mechanisms and explore novel therapeutic approaches for rare kidney diseases. The ultimate goal is to improve the dismal prognosis of patient with these disorders.

Descrizione progetto (Article)

Rare kidney diseases are a group of disorders of unknown genetic or molecular aetiology and are characterised by significant phenotypic variability. Although they have a dismal impact on life expectancy and quality of life, diagnostic and therapeutic management options are highly unsatisfactory. Currently there are no molecular markers or models to allow for efficient prediction of disease risk.

High-throughput studies are possible for rare kidney diseases using kidney biopsies. Subsequent transcriptomic, proteomic and morphological analyses should provide invaluable insight into the pathogenesis of these rare disorders. In addition, urine and amniotic fluid constitute excellent molecular readouts that could give an indication of renal malfunction.

The EU-funded http://www.eurenomics.eu/ (EURENOMICS) (European consortium for high-throughput research in rare kidney diseases) project is utilising high-throughput technologies to perform a large scale analysis of patient samples. The consortium has access to a large cohort of over 15 000 patients and biorepositories of DNA, serum, amniotic fluid and kidney biopsy specimens.

The activities of the project include the search for new genes that cause, modify or predispose individuals to disease phenotypes. So far novel disease-causing mutations and genomic rearrangements have been detected, while exome sequencing has identified new genes implicated in these disorders. Numerous additional candidate disease genes are currently undergoing functional characterisation.

The consortium is also performing multi-level molecular profiling (mRNA, miRNA, proteome, metabolome) of body fluids and renal tissues to identify unique molecular disease signatures. They are searching for novel antigens and antibodies, and have made significant progress with respect to the molecular mechanisms of auto-immune disease.

Fundamental new insights into disease penetrance indicated that in NPHS2 glomerulopathy, phenotype is directly dependent on the nature of the combining mutations. This discovery is the first description of mutation-dependent recessive inheritance in human genetics.

From a therapeutic perspective, scientists have developed in vitro and in vivo models for screening compound libraries for novel therapeutic agents. Combined with other technologies they envisage diagnostic progress, risk prediction as well as strategies for disease management.

Altri progetti dello stesso programma (FP7-HEALTH)

PREDICT (2008)

Increasing the PaRticipation of the ElDerly in Clinical Trials

Read More  

LIV-ES (2008)

Development of culture conditions for the differentiation of hES cells into hepatocytes

Read More  

BIO-NMD (2009)

Identifying and validating pre-clinical biomarkers for diagnostics and therapeutics of Neuromuscular Disorders

Read More